294 research outputs found
Algebraic and Topological Indices of Molecular Pathway Networks in Human Cancers
Protein-protein interaction networks associated with diseases have gained
prominence as an area of research. We investigate algebraic and topological
indices for protein-protein interaction networks of 11 human cancers derived
from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We find a
strong correlation between relative automorphism group sizes and topological
network complexities on the one hand and five year survival probabilities on
the other hand. Moreover, we identify several protein families (e.g. PIK, ITG,
AKT families) that are repeated motifs in many of the cancer pathways.
Interestingly, these sources of symmetry are often central rather than
peripheral. Our results can aide in identification of promising targets for
anti-cancer drugs. Beyond that, we provide a unifying framework to study
protein-protein interaction networks of families of related diseases (e.g.
neurodegenerative diseases, viral diseases, substance abuse disorders).Comment: 15 pages, 4 figure
Tool And Blank Interaction In The Cross-Die Forming Process
The deformation of the press and the forming tools during a deep drawing process is small. However, it has a significant influence on the formed product, since the draw-in is affected significantly by this deformation. This effect is demonstrated for the cross-die forming process. The process was simulated using the commercial code ABAQUS, comparing different models for the forming tools and blank. The simulated process behaves quite differently when rigid or deformable tools are applied. In the latter case, so-called tool-spacers absorb a significant part of the blankholder load, resulting in a stronger draw-in of the blank. In all cases, the results depended heavily on the blank element type and on numerical settings for the contact algorithm. These should be treated with great care when accurate results are required
Separation of bacterial spores from flowing water in macro-scale cavities by ultrasonic standing waves
The separation of micron-sized bacterial spores (Bacillus cereus) from a
steady flow of water through the use of ultrasonic standing waves is
demonstrated. An ultrasonic resonator with cross-section of 0.0254 m x 0.0254 m
has been designed with a flow inlet and outlet for a water stream that ensures
laminar flow conditions into and out of the resonator section of the flow tube.
A 0.01905-m diameter PZT-4, nominal 2-MHz transducer is used to generate
ultrasonic standing waves in the resonator. The acoustic resonator is 0.0356 m
from transducer face to the opposite reflector wall with the acoustic field in
a direction orthogonal to the water flow direction. At fixed frequency
excitation, spores are concentrated at the stable locations of the acoustic
radiation force and trapped in the resonator region. The effect of the
transducer voltage and frequency on the efficiency of spore capture in the
resonator has been investigated. Successful separation of B. cereus spores from
water with typical volume flow rates of 40-250 ml/min has been achieved with
15% efficiency in a single pass at 40 ml/min.Comment: 11 pages, 6 figure
- …