998 research outputs found
Water Law: Recognition of a Public Water Right (Paradise Rainbows v. Fish and Game Commission, 421 P.2d 717, 1966)
Recent Decision
The Montana Inheritance Tax
The Montana Inheritance Ta
The Constitution of the United States Applies to Indian Tribes
The Constitution of the United States Applies to Indian Tribe
The Constitution of the United States Applies to Indian Tribes: A Reply to Professor Jensen
The Constitution of the United States Applies to Indian Tribes: A Reply to Professor Jense
Three Algorithms for a Class of Multidimensional Assignment Problems
The assignment problem of matching the elements of two sets at some cost or to some benefit is well known and can be solved in polynomial time. However, many applications, particularly those in remote sensing and computer vision, require matching elements from more than two sets at some cost. Such problems are called multidimensional assignment problems and are known to be NP-hard. For time-critical applications and nontrivial multidimensional assignment problems, fast near-optimal algorithms are the only alternative. This paper compares three such algorithms: greedy, limited branch and bound, and Lagrangian relaxation
IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart
Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II. We previously found marked down-regulation of cardiac CRH receptor type 2 expression following administration of bacterial endotoxin, lipopolysaccharide, a model of systemic immune activation, and inflammation. We postulated that inflammatory cytokines may regulate CRH receptor type 2. We show that systemic IL-1α administration significantly down-regulates CRH receptor type 2 mRNA in mouse heart. In addition, TNFα treatment also reduces CRH receptor type 2 mRNA expression, although the effect was not as marked as with IL-1α. However, CRH receptor type 2 mRNA expression is not altered in adult mouse ventricular cardiomyocytes stimulated in vitro with TNFα or IL-1α. Thus, cytokine regulation may be indirect. Exogenous administration of corticosterone in vivo or acute restraint stress also reduces cardiac CRH receptor type 2 mRNA expression, but like cytokines, in vitro corticosterone treatment does not modulate expression in cardiomyocytes. Interestingly, treatment with urocortin significantly decreases CRH receptor type 2 mRNA in cultured cardiomyocytes. We speculate that in vivo, inflammatory mediators such as lipopolysaccharide and/or cytokines may increase urocortin, which in turn down-regulates CRH receptor type 2 expression in the heart. Because CRH and urocortin increase cardiac contractility and coronary blood flow, impaired CRH receptor type 2 function during systemic inflammation may ultimately diminish the adaptive cardiac response to adverse conditions
Demystifying Research: Accessing & Understanding Evidence for Clinical Practice
The demands on clinicians for evidence-based practice (EBP) are great. However, many speech-language pathologists have received little to no training in how to ‘do’ EBP. In this presentation, we aim to describe and provide practical suggestions for two of the steps in EBP—accessing, then reading and interpreting research to inform clinical decision-making. Our goal is to give clinicians the tools and confidence they need to grow into expert clinicians.
Learner Outcome 1: Describe the components of evidence-based practice (EBP)
Learner Outcome 2: Identify ways to access research
Learner Outcome 3: Identify steps in reading and evaluating the quality of a research articl
Correlation of the middle Eocene Kellogg Shale of northern California
The Kellogg Shale of northern California has traditionally been considered to be late Eocene in age on the basis of benthic foraminifer, radiolarian, and diatom correlations. The 30-m-thick Kellogg section exposed west of Byron, California, however, contains middle Eocene planktonic foraminifers (Zone P12), coccoliths (Subzones CP13c and CP14a), silicoflagellates (Dictyocha hexacantha Zone), and diatoms. Quantitative studies of the silicoflagellates and diatoms show a general cooling trend through the section which is consistent with paleoclimatic trends for this part of the middle Eocene (ca. 42-45 Ma) from elsewhere in the world. Seven new silicoflagellate taxa (Corbisema angularis. C, exilis, C, hastate miranda, C. inermis ballantina, C. regina, Dictyocha byronalis, Naviculopsis Americana) and one new coccolithophorid species (Helicosphaera neolophota) are described
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