Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans

<p>Abstract</p> <p>Background</p> <p>It has been known that hypertension is an independent risk factor for cardiovascular disease (CVD). CVD is the major cause of morbidity and mortality in developed and developing countries. Elevation of blood pressure (BP) increases the adverse effect for cardiovascular outcomes. Prevention of increased BP plays a crucial role in a reduction of those outcomes, leading to a decrease in mortality. Therefore, the purpose of this study was to investigate the effects of dietary black sesame meal on BP and oxidative stress in individuals with prehypertension.</p> <p>Methods</p> <p>Twenty-two women and eight men (aged 49.8 ± 6.6 years) with prehypertension were randomly divided into two groups, 15 subjects per group. They ingested 2.52 g black sesame meal capsules or placebo capsules each day for 4 weeks. Blood samples were obtained after overnight fasting for measurement of plasma lipid, malondialdehyde (MDA) and vitamin E levels. Anthropometry, body composition and BP were measured before and after 4-week administration of black sesame meal or a placebo.</p> <p>Results</p> <p>The results showed that 4-week administration of black sesame meal significantly decreased systolic BP (129.3 ± 6.8 vs. 121.0 ± 9.0 mmHg, <it>P </it>< 0.05) and MDA level (1.8 ± 0.6 vs. 1.2 ± 0.6 μmol/L, <it>P </it>< 0.05), and increased vitamin E level (29.4 ± 6.0 vs. 38.2 ± 7.8 μmol/L, <it>P </it>< 0.01). In the black sesame meal group, the change in SBP tended to be positively related to the change in MDA (<it>R = 0.50, P </it>= 0.05), while the change in DBP was negatively related to the change in vitamin E (<it>R = -0.55, P </it>< 0.05). There were no correlations between changes in BP and oxidative stress in the control group.</p> <p>Conclusions</p> <p>These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. These data may imply a beneficial effect of black sesame meal on prevention of CVD.</p

Global haplotype partitioning for maximal associated SNP pairs

<p>Abstract</p> <p>Background</p> <p>Global partitioning based on pairwise associations of SNPs has not previously been used to define haplotype blocks within genomes. Here, we define an association index based on LD between SNP pairs. We use the Fisher's exact test to assess the statistical significance of the LD estimator. By this test, each SNP pair is characterized as associated, independent, or not-statistically-significant. We set limits on the maximum acceptable proportion of independent pairs within all blocks and search for the partitioning with maximal proportion of associated SNP pairs. Essentially, this model is reduced to a constrained optimization problem, the solution of which is obtained by iterating a dynamic programming algorithm.</p> <p>Results</p> <p>In comparison with other methods, our algorithm reports blocks of larger average size. Nevertheless, the haplotype diversity within the blocks is captured by a small number of tagSNPs. Resampling HapMap haplotypes under a block-based model of recombination showed that our algorithm is robust in reproducing the same partitioning for recombinant samples. Our algorithm performed better than previously reported models in a case-control association study aimed at mapping a single locus trait, based on simulation results that were evaluated by a block-based statistical test. Compared to methods of haplotype block partitioning, we performed best on detection of recombination hotspots.</p> <p>Conclusion</p> <p>Our proposed method divides chromosomes into the regions within which allelic associations of SNP pairs are maximized. This approach presents a native design for dimension reduction in genome-wide association studies. Our results show that the pairwise allelic association of SNPs can describe various features of genomic variation, in particular recombination hotspots.</p

Improved value for load increase factor in disproportionate collapse

Current design guidelines for General Service Administration (GSA 2003 & 2013), United Facilities Criteria (UFC 2009) adopt the alternate path method for disproportionate collapse-resistant structures design. In the alternate path design approach, a critical structural component (typically a key column) is suddenly removed from the system and the ability of the other components of the structural system to withstand the added forces is examined. This can be done using linear or nonlinear static analysis (LSA and NSA) as well as the nonlinear dynamic analysis (NDA) method. In the dynamic method, the inertial forces are directly considered in the analysis through the equations of motion. However, a Load Increase Factor (LIF) is introduced in the static analysis methods to account for the modifications of dead and live loads due to the unaccounted for dynamic effects. The LIF value recommended by GSA (2003) is 2.0, while it is derived based on recommended equations adopted by GSA (2013) and UFC (2009). In this study, dynamic analyses of a multi-story building subjected to sudden column removal are conducted taking into consideration geometric nonlinearity and material inelasticity. Based on these analyses, the LIF is computed and compared with design recommendations. The results from this study indicate that the current values of LIF need to be re-evaluated in order to achieve more economical designs

Risk-based seismic design for optimal structural and nonstructural system performance

An automated performance-based design methodology to optimize structural and nonstructural system performance is outlined and it is shown that it can be used to enhance understanding of structural steel system design for minimum life-cycle costs. Performance is assessed using loss probability with direct economic loss expressed as a percentage of the building replacement cost. Time-based performance assessment is used to compute the expected annual loss of a given steel framing system assuming exposure to three seismic hazard levels. Damage to the structural system, nonstructural displacement-sensitive components, and nonstructural acceleration-sensitive components is characterized using fragility functions. A steel building with three-story, four-bay topology taken from the literatureis used to demonstrate application of the algorithm with subsequent comparison of designsobtained using the proposed methodology and others found in the literature. © VC 2011, Earthquake Engineering Research Institute