Finite lifetime eigenfunctions of coupled systems of harmonic oscillators

We find a Hermite-type basis for which the eigenvalue problem associated to the operator $H_{A,B}:=B(-\partial_x^2)+Ax^2$ acting on $L^2({\bf R};{\bf C}^2)$ becomes a three-terms recurrence. Here $A$ and $B$ are two constant positive definite matrices with no other restriction. Our main result provides an explicit characterization of the eigenvectors of $H_{A,B}$ that lie in the span of the first four elements of this basis when $AB\not= BA$.Comment: 11 pages, 1 figure. Some typos where corrected in this new versio

Modelling cytoskeletal traffic: an interplay between passive diffusion and active transport

We introduce the totally asymmetric exclusion process with Langmuir kinetics (TASEP-LK) on a network as a microscopic model for active motor protein transport on the cytoskeleton, immersed in the diffusive cytoplasm. We discuss how the interplay between active transport along a network and infinite diffusion in a bulk reservoir leads to a heterogeneous matter distribution on various scales. We find three regimes for steady state transport, corresponding to the scale of the network, of individual segments or local to sites. At low exchange rates strong density heterogeneities develop between different segments in the network. In this regime one has to consider the topological complexity of the whole network to describe transport. In contrast, at moderate exchange rates the transport through the network decouples, and the physics is determined by single segments and the local topology. At last, for very high exchange rates the homogeneous Langmuir process dominates the stationary state. We introduce effective rate diagrams for the network to identify these different regimes. Based on this method we develop an intuitive but generic picture of how the stationary state of excluded volume processes on complex networks can be understood in terms of the single-segment phase diagram.Comment: 5 pages, 7 figure

Motor proteins traffic regulation by supply-demand balance of resources

In cells and in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow chamber) and hence compete for recruiting the available motors, potentially depleting the reservoir and affecting cytoskeletal transport. In this work we provide a theoretical framework to study, analytically and numerically, how motor density profiles and crowding along cytoskeletal filaments depend on the competition of motors for their binding sites. We propose two models in which finite processive motor proteins actively advance along cytoskeletal filaments and are continuously exchanged with the motor pool. We first look at homogeneous reservoirs and then examine the effects of free motor diffusion in the surrounding medium. We consider as a reference situation recent in vitro experimental setups of kinesin-8 motors binding and moving along microtubule filaments in a flow chamber. We investigate how the crowding of linear motor proteins moving on a filament can be regulated by the balance between supply (concentration of motor proteins in the flow chamber) and demand (total number of polymerised tubulin heterodimers). We present analytical results for the density profiles of bound motors, the reservoir depletion, and propose novel phase diagrams that present the formation of jams of motor proteins on the filament as a function of two tuneable experimental parameters: the motor protein concentration and the concentration of tubulins polymerized into cytoskeletal filaments. Extensive numerical simulations corroborate the analytical results for parameters in the experimental range and also address the effects of diffusion of motor proteins in the reservoir.Comment: 31 pages, 10 figure

Markov Process of Muscle Motors

We study a Markov random process describing a muscle molecular motor behavior. Every motor is either bound up with a thin filament or unbound. In the bound state the motor creates a force proportional to its displacement from the neutral position. In both states the motor spend an exponential time depending on the state. The thin filament moves at its velocity proportional to average of all displacements of all motors. We assume that the time which a motor stays at the bound state does not depend on its displacement. Then one can find an exact solution of a non-linear equation appearing in the limit of infinite number of the motors.Comment: 10 page

The extended structure of the remote cluster B514 in M31. Detection of extra-tidal stars

We present a study of the density profile of the remote M31 globular cluster B514, obtained from HST/ACS observations. Coupling the analysis of the distribution of the integrated light with star counts we can reliably follow the profile of the cluster out to r~35", corresponding to ~130pc. The profile is well fitted, out to ~15 core radii, by a King Model having C=1.65. With an estimated core radius r_c=0.38", this corresponds to a tidal radius of r_t~17" (~65pc). We find that both the light and the star counts profiles show a departure from the best fit King model for r>~8" - as a surface brightness excess at large radii, and the star counts profile shows a clear break in correspondence of the estimated tidal radius. Both features are interpreted as the signature of the presence of extratidal stars around the cluster. We also show that B514 has a half-light radius significantly larger than ordinary globular clusters of the same luminosity. In the M_V vs. log r_h plane, B514 lies in a region inhabited by peculiar clusters, like Omega Cen, G1, NGC2419 and others, as well as by the nuclei of dwarf elliptical galaxies.Comment: 9 pages, 6 figures. Accepted for publication in Astronomy & Astrophysic

Mixed population of competing TASEPs with a shared reservoir of particles

We introduce a mean-field theoretical framework to describe multiple totally asymmetric simple exclusion processes (TASEPs) with different lattice lengths, entry and exit rates, competing for a finite reservoir of particles. We present relations for the partitioning of particles between the reservoir and the lattices: these relations allow us to show that competition for particles can have non-trivial effects on the phase behavior of individual lattices. For a system with non-identical lattices, we find that when a subset of lattices undergoes a phase transition from low to high density, the entire set of lattice currents becomes independent of total particle number. We generalize our approach to systems with a continuous distribution of lattice parameters, for which we demonstrate that measurements of the current carried by a single lattice type can be used to extract the entire distribution of lattice parameters. Our approach applies to populations of TASEPs with any distribution of lattice parameters, and could easily be extended beyond the mean-field case.Comment: 12 pages, 8 figure

One-pot multi-enzymatic synthesis of the four stereoisomers of 4-methylheptan-3-ol

The use of pheromones in the integrated pest management of insects is currently considered a sustainable and environmentally benign alternative to hazardous insecticides. 4-Methylheptan-3-ol is an interesting example of an insect pheromone, because its stereoisomers are active towards different species. All four possible stereoisomers of this compd. were prepd. from 4-methylhept-4-en-3-one by a one-pot procedure in which the two stereogenic centers were created during two sequential redns. catalyzed by an ene-reductase (ER) and an alc. dehydrogenase (ADH), resp

Phase Coexistence in Driven One Dimensional Transport

We study a one-dimensional totally asymmetric exclusion process with random particle attachments and detachments in the bulk. The resulting dynamics leads to unexpected stationary regimes for large but finite systems. Such regimes are characterized by a phase coexistence of low and high density regions separated by domain walls. We use a mean-field approach to interpret the numerical results obtained by Monte-Carlo simulations and we predict the phase diagram of this non-conserved dynamics in the thermodynamic limit.Comment: 4 pages, 3 figures. Accepted for publication on Phys. Rev. Let