In vitro screening for antitumour activity of Clinopodium vulgare L. (Lamiaceae) extracts.

Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 microg/ml it reduced the cell survival to 1.0, 5.6 and 6.6%, respectively. The concentrations of aqueous extract inhibiting the growth of A2058, HEp-2 and L5178Y cells by 50% (IC50 values) were calculated to be 20, 10 and 17.8 microg/ml respectively. Two groups of active substances were detected: the first one, probably combining glycosides, influenced adhesion, while the second one caused massive cell vacuolisation. The chloroform extract, which contained ursolic acid and gentriacontan had also cytotoxic, however a little bit weaker effect. All changes observed were irreversible

Landscape, race, and power on the Indo-Afghan frontier, c.1840-c.1880

Landscape defined a problem of colonial rule on the nineteenth-century Indo-Afghan frontier, connected, as it was, to contemporary ideas about difference, novelly articulated in racial terms. This connection was the product of numerous developments, drawing on Enlightenment ideas about race and development and on historical analogy with the late eighteenth-century Scottish Highlands, as well as the nineteenth-century ethnographic inquiry linking geographic isolation with racial preservation or descent. These ‘noble savages’ were also more likely to fall under the spell of charismatic Sufi leaders, spurring them to fierce resistance of political authority and acts of violence, and earning them a reputation for ‘fanaticism’. Landscape also presented a problem for the expression of colonial power; for the ruggedness and remoteness of the frontier made the expatriate population vulnerable in an area where the colonial presence remained thin and where criminal prosecution could be easily evaded. The consequence was the Frontier Crimes Regulation, which devolved authority for the prosecution of crime and execution of justice to the heads of tribal societies according to local custom, and the Murderous Outrages Act, which empowered colonial officers to suspend due judicial process and order anachronistic and morally abhorrent forms of punishment. Just as ideas about race were ambivalent and contradictory, so, too, was colonial law