2,247 research outputs found

    Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

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    This paper presents measurements of the W+μ+νW^+ \rightarrow \mu^+\nu and WμνW^- \rightarrow \mu^-\nu cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

    Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

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    A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

    Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector

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    A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino

    Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

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    Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

    Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

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    <p>Abstract</p> <p>Background</p> <p>Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies. Therapeutic antibodies fully lacking the core fucose of the Fc oligosaccharides have been found to exhibit much higher ADCC in humans than their fucosylated counterparts. However, data which show how fully non-fucosylated antibodies achieve such a high ADCC in human whole blood have not yet been disclosed. The precise mechanisms responsible for the high ADCC mediated by fully non-fucosylated therapeutic antibodies, even in the presence of human plasma, should be explained based on direct evidence of non-fucosylated antibody action in human blood.</p> <p>Methods</p> <p>Using a human <it>ex vivo </it>B-cell depletion assay with non-fucosylated and fucosylated anti-CD20 IgG1s rituximab, we monitored the binding of the therapeutic agents both to antigens on target cells (target side interaction) and to leukocyte receptors (FcγR) on effector cells (effector side interaction), comparing the intensities of ADCC in human blood.</p> <p>Results</p> <p>In the target side interaction, down-modulation of CD20 on B cells mediated by anti-CD20 was not observed. Simple competition for binding to the antigens on target B cells between fucosylated and non-fucosylated anti-CD20s was detected in human blood to cause inhibition of the enhanced ADCC of non-fucosylated anti-CD20 by fucosylated anti-CD20. In the effector side interaction, non-fucosylated anti-CD20 showed sufficiently high FcγRIIIa binding activity to overcome competition from plasma IgG for binding to FcγRIIIa on natural killer (NK) cells, whereas the binding of fucosylated anti-CD20 to FcγRIIIa was almost abolished in the presence of human plasma and failed to recruit NK cells effectively. The core fucosylation levels of individual serum IgG1 from healthy donors was found to be so slightly different that it did not affect the inhibitory effect on the ADCC of fucosylated anti-CD20.</p> <p>Conclusion</p> <p>Our results demonstrate that removal of fucosylated antibody ingredients from antibody therapeutics elicits high ADCC in human blood by two mechanisms: namely, by evading the inhibitory effects both of plasma IgG on FcγRIIIa binding (effector side interaction) and of fucosylated antibodies on antigen binding (target side interaction).</p

    Regulation of the High Affinity IgE Receptor (FcεRI) in Human Neutrophils: Role of Seasonal Allergen Exposure and Th-2 Cytokines

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    The high affinity IgE receptor, FcεRI, plays a key role in the immunological pathways involved in allergic asthma. Previously we have demonstrated that human neutrophils isolated from allergic asthmatics express a functional FcεRI, and therefore it was of importance to examine the factors regulating its expression. In this study, we found that neutrophils from allergic asthmatics showed increased expression of FcεRI-α chain surface protein, total protein and mRNA compared with those from allergic non asthmatics and healthy donors (p<0.001). Interestingly, in neutrophils isolated from allergic asthmatics, FcεRI-α chain surface protein and mRNA expression were significantly greater during the pollen season than outside the pollen season (n = 9, P = 0.001), an effect which was not observed either in the allergic non asthmatic group or the healthy donors (p>0.05). Allergen exposure did not affect other surface markers of neutrophils such as CD16/FcγRIII or IL-17R. In contrast to stimulation with IgE, neutrophils incubated with TH2 cytokines IL-9, GM-CSF, and IL-4, showed enhanced FcεRI-α chain surface expression. In conclusion, these results suggest that enhanced FcεRI expression in human neutrophils from allergic asthmatics during the pollen season can make them more susceptible to the biological effects of IgE, providing a possible new mechanism by which neutrophils contribute to allergic asthma

    Performance of electron and photon triggers in ATLAS during LHC Run 2

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    Electron and photon triggers covering transverseenergies from 5 GeV to several TeV are essential for theATLAS experiment to record signals for a wide variety ofphysics: from Standard Model processes to searches for newphenomena in both proton–proton and heavy-ion collisions.To cope with a fourfold increase of peak LHC luminosityfrom 2015 to 2018 (Run 2), to 2.1×1034cm−2s−1, anda similar increase in the number of interactions per beam-crossing to about 60, trigger algorithms and selections wereoptimised to control the rates while retaining a high effi-ciency for physics analyses. For proton–proton collisions, thesingle-electron trigger efficiency relative to a single-electronoffline selection is at least 75% for an offline electron of31 GeV, and rises to 96% at 60 GeV; the trigger efficiency ofa 25 GeV leg of the primary diphoton trigger relative to a tightoffline photon selection is more than 96% for an offline pho-ton of 30 GeV. For heavy-ion collisions, the primary electronand photon trigger efficiencies relative to the correspondingstandard offline selections are at least 84% and 95%, respec-tively, at 5 GeV above the corresponding trigger threshold

    Differential cross-section measurements for the electroweak production of dijets in association with a Z boson in proton–proton collisions at ATLAS

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    Differential cross-section measurements are presented for the electroweak production of two jets in association with a Z boson. These measurements are sensitive to the vector-boson fusion production mechanism and provide a fundamental test of the gauge structure of the Standard Model. The analysis is performed using proton–proton collision data collected by ATLAS at s=13TeVs=13 TeV\sqrt{s}=13\ \hbox {TeV} and with an integrated luminosity of 139fb-1139 fb1139\ \hbox {fb}^{-1}. The differential cross-sections are measured in the Z→ℓ+ℓ-Z+Z\rightarrow \ell ^+\ell ^- decay channel (ℓ=e,μ=e,μ\ell =e,\mu ) as a function of four observables: the dijet invariant mass, the rapidity interval spanned by the two jets, the signed azimuthal angle between the two jets, and the transverse momentum of the dilepton pair. The data are corrected for the effects of detector inefficiency and resolution and are sufficiently precise to distinguish between different state-of-the-art theoretical predictions calculated using Powheg+Pythia8, Herwig7+Vbfnlo and Sherpa 2.2. The differential cross-sections are used to search for anomalous weak-boson self-interactions using a dimension-six effective field theory. The measurement of the signed azimuthal angle between the two jets is found to be particularly sensitive to the interference between the Standard Model and dimension-six scattering amplitudes and provides a direct test of charge-conjugation and parity invariance in the weak-boson self-interactions

    Measurement of angular and momentum distributions of charged particles within and around jets in Pb+Pb and pp collisions at √sNN = 5.02 TeV with the ATLAS detector

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    Studies of the fragmentation of jets into charged particles in heavy-ion collisions can provide information about the mechanism of jet quenching by the hot and dense QCD matter created in such collisions, the quark-gluon plasma. This paper presents a measurement of the angular distribution of charged particles around the jet axis in √ s N N = 5.02 TeV Pb + Pb and pp collisions, using the ATLAS detector at the LHC. The Pb + Pb and p p data sets have integrated luminosities of 0.49 nb − 1 and 25 pb − 1 , respectively. The measurement is performed for jets reconstructed with the anti- k t algorithm with radius parameter R = 0.4 and is extended to an angular distance of r = 0.8 from the jet axis. Results are presented as a function of Pb + Pb collision centrality and distance from the jet axis for charged particles with transverse momenta in the 1- to 63-GeV range, matched to jets with transverse momenta in the 126- to 316-GeV range and an absolute value of jet rapidity of less than 1.7. Modifications to the measured distributions are quantified by taking a ratio to the measurements in p p collisions. Yields of charged particles with transverse momenta below 4 GeV are observed to be increasingly enhanced as a function of angular distance from the jet axis, reaching a maximum at r = 0.6 . Charged particles with transverse momenta above 4 GeV have an enhanced yield in Pb + Pb collisions in the jet core for angular distances up to r = 0.05 from the jet axis, with a suppression at larger distances

    Measurements of top-quark pair differential and double-differential cross-sections in the ℓ+jets channel with pp collisions at s√=13 TeV using the ATLAS detector

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    open35siSingle- and double-differential cross-section measurements are presented for the production of top-quark pairs, in the lepton + jets channel at particle and parton level. Two topologies, resolved and boosted, are considered and the results are presented as a function of several kinematic variables characterising the top and tt ¯ system and jet multiplicities. The study was performed using data from pp collisions at centre-of-mass energy of 13 TeV collected in 2015 and 2016 by the ATLAS detector at the CERN Large Hadron Collider (LHC), corresponding to an integrated luminosity of 36 fb−1. Due to the large tt ¯ cross-section at the LHC, such measurements allow a detailed study of the properties of top-quark production and decay, enabling precision tests of several Monte Carlo generators and fixed-order Standard Model predictions. Overall, there is good agreement between the theoretical predictions and the data.openDe Castro , S. ; Fabbri , L. ; Gabrielli , A. ; Rinaldi , L. ; Semprini Cesari , N. ; Sioli , M. ; Villa , M. ; Zoccoli , A. ; Bellagamba , L. ; Boscherini , D. ; Bruni , A.. ; Bruni , G. ; D’Amen , G. ; Giacobbe , B. ; Polini , A. ; Sbarra , C. ; Sidoti , A. ; Spighi , R. ; Franchini , M. ; Mengarelli , A. ; Romano , M. ; Valentinetti , S. ; Alberghi , G. L. ; Biondi , S. ; Fabbri , F. ; Lasagni Manghi , F; Massa , L. ; Ucchielli , G. ; Vittori , C. ; Alfonsi , F: ; Cabras , G. ; Cervelli , A. ; Giangiacomi , N. ; Negrini , M. ; ATLAS collaborationDe Castro , S. ; Fabbri , L. ; Gabrielli , A. ; Rinaldi , L. ; Semprini Cesari , N. ; Sioli , M. ; Villa , M. ; Zoccoli , A. ; Bellagamba , L. ; Boscherini , D. ; Bruni , A. ; Bruni , G. ; D’Amen , G. ; Giacobbe , B. ; Polini , A. ; Sbarra , C. ; Sidoti , A. ; Spighi , R. ; Franchini , M. ; Mengarelli , A. ; Romano , M. ; Valentinetti , S. ; Alberghi , G. L. ; Biondi , S. ; Fabbri , F. ; Lasagni Manghi , F; Massa , L. ; Ucchielli , G. ; Vittori , C. ; Alfonsi , F: ; Cabras , G. ; Cervelli , A. ; Giangiacomi , N. ; Negrini , M. ; ATLAS collaboratio
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