665 research outputs found

    Surveillance of anti-HCV antibody amongst in-school youth in a Nigeria university

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    Infection with Hepatitis C Virus (HCV) is a public health problem. Worldwide, there are about 170 million people infected with HCV. HCV is transmitted through sex and use of contaminated sharp objects during tattooing or intravenous drug abuse. These routes make youth to be more vulnerable. Transfusion and mother to child transmissions are also documented modes. This study was carried out to determine sero-prevalence of hepatitis C virus infection among in school youth at Achievers University, Owo in southwest Nigeria. Samples of blood were collected from 70 undergraduate students and sera harvested were tested for the presence of antibodies against hepatitis C virus by Enzyme Immunoassay Technique. Most participants fall within age range 21-25 (91.4%). The study showed that none of the subjects was positive for anti- HCV antibodies. Education and awareness level might have impacted positively on this outcome. Thus routine screening for HCV and sustained awareness creation activities to eradicate HCV and its attendant consequences from our society is of paramount importance.Key words: HCV, prevalence, in-school youth, education

    Estimation of Human Health Risk Due to Heavy Metals around Schools and Auto-Mobile Workshops near Frequented Roads in Kaduna State, Nigeria

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    Heavy metals are widely known for their potential to cause carcinogenic and non-carcinogenic health risks. In this work, the carcinogenic and non-carcinogenic health risks associated with heavy metals in the vicinity of schools and auto mechanic workshops close to busy roads in Kaduna state was assessed using NEX CG EDXRF MODEL with brand name RIGAKU situated at a UTM Laboratory, Malaysia. The obtained heavy metals concentrations were used to estimate the health effects that might result from exposure to carcinogenic and non-carcinogenic chemicals for both the population ages using US EPA methodology. Findings indicated that in some locations the carcinogenic and non-carcinogenic hazards associated with exposure for residents was greater than the US EPA acceptable thresholds of 10-4 and 1 respectively. This indicated that the heavy metals may result to unacceptable carcinogenic and non-carcinogenic risks, which is an issue of concern in public health especially looking at the way school children play around these areas. The present study therefore provides scientific basis for strategies required to protect human and environmental health in schools and automobile workshops

    Genetic Susceptibility to Acute Rheumatic Fever: A Systematic Review and Meta-Analysis of Twin Studies

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    Acute rheumatic fever is considered to be a heritable condition, but the magnitude of the genetic effect is unknown. The objective of this study was to conduct a systematic review and meta-analysis of twin studies of concordance of acute rheumatic fever in order to derive quantitative estimates of the size of the genetic effect.We searched PubMed/MEDLINE, ISI Web of Science, EMBASE, and Google Scholar from their inception to 31 January 2011, and bibliographies of retrieved articles, for twin studies of the concordance for acute rheumatic fever or rheumatic heart disease in monozygotic versus dizygotic twins that used accepted diagnostic criteria for acute rheumatic fever and zygosity without age, gender or language restrictions. Twin similarity was measured by probandwise concordance rate and odds ratio (OR), and aggregate probandwise concordance risk was calculated by combining raw data from each study. ORs from separate studies were combined by random-effects meta-analysis to evaluate association between zygosity status and concordance. Heritability was estimated by fitting a variance components model to the data.435 twin pairs from six independent studies met the inclusion criteria. The pooled probandwise concordance risk for acute rheumatic fever was 44% in monozygotic twins and 12% in dizygotic twins, and the association between zygosity and concordance was strong (OR 6.39; 95% confidence interval, 3.39 to 12.06; P<0.001), with no significant study heterogeneity (P = 0.768). The estimated heritability across all the studies was 60%.Acute rheumatic fever is an autoimmune disorder with a high heritability. The discovery of all genetic susceptibility loci through whole genome scanning may provide a clinically useful genetic risk prediction tool for acute rheumatic fever and its sequel, rheumatic heart disease

    A ROBUST FACE RECOGNITION ALGORITHM USING A TEMPLATE APPROACH

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    In this paper a system that uses a template matching approach along with a training algorithm for tuning performance was described. The system solves two types of problems at the same time: 1. correct identification of individuals in the image database. 2. Rejection of individuals who are not in the database. Results show that this training method is capable of a consistent correct classification rates and a low false positive rates

    Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman Disease): Report of a case in a Nigerian Teaching Hospital

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    Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare, benign disease of unknown aetiology. This disease typically presents with massive, painless cervical lymphadenopathy but may occur in a wide variety of extranodal sites. This report describes a 43-year old man with a left submandibular swelling and left lateral cervical lymphadenopathy clinically suggestive of a malignancy. Initial cytological examination of a fine needle aspirate specimen taken from the mass suggested a chronic granulomatous inflammatory lesion. A definitive diagnosis of SHML was however made only after excisional biopsy of the lesion. The patient was followed up for 6 months and no recurrence of the lesion was observed. SHML may be considered a rare lesion among Nigerians. Knowledge of its clinical presentation with understanding of the differentials diagnosis is important to avoid unnecessary intervention. The diagnosis can be made from FNAC, histopathology and immune-histochemistry. There is no ideal protocol for the treatment. Follow-up is however necessary to detect relapses

    EVALUATION OF TWO-STAGE SUBSURFACE FLOW CONSTRUCTED WETLANDS FOR ABATTOIR WASTEWATER MANAGEMENT

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    Abattoir wastewater is high in organic content, the waste recovery and treatment facility is expensive and this results in indiscriminate dumping into streams without adequate treatment. The effectiveness of using a two-stage subsurface flow constructed wetland to treat abattoir effluent was examined in this study. Diluted abattoir wastewater from Lafenwa Abattoir, Abeokuta, Ogun State, Nigeria was fed into a two-stage Vegetated Subsurface Bed Constructed Wetlands (VSBCW). The VSBCW consisted of 500 mm deep 10-15 mm diameter granite with 150 mm thick overlay of well graded sand planted with locally available Vetiveria nigritana. Grab samples were collected at selected points along Ogun river and measurement of physico-chemical parameters such as: Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD5), Electrical Conductivity (EC), Total Dissolved Solids (TDS) and Total Suspended Solid (TSS) of the influent and effluent from the VSBCW were carried out. Irrigation with water and diluted abattoir wastewater to examine the variation in plant growth rate was also investigated. The results revealed a pollution load reduction as the wastewater moves away from the discharge point but inadequate to meet the FEPA (1991) standard for wastewater discharge into rivers. The VSBCW was observed to reduce the concentration of BOD5, COD, EC, TDS and TSS in the abattoir wastewater by 88.71, 87.28, 45.72, 56.89 and 72.27 % respectively. The growth rate of the V. nigritana reduced by 1.9% when irrigated with abattoir wastewater. The study revealed that locally available V. nigritana in VSBCW is effective in abattoir wastewater treatment and could be use to curtail the pollution caused by discharge of untreated wastewater into rivers. &nbsp; &nbsp; &nbsp

    Qualitative Assessment of Surgical Repair of Three Types of Unilateral Cleft Lip

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    Objective:&nbsp;To assess the effect of the three types of unilateral cleft lip (UCL) [cleft lip only, cleft lip and alveolus, and cleft lip alveolus and palate] on the outcome of the repair. Material and Methods: This study was a case series of effect of types of UCL on the outcome of the repair. Fifteen subjects each were in three UCL phenotypes groups. Evaluation of the scar, lip, and nose was done qualitatively by both parents/guardians and professionals using a modified form of the criteria described by Christofides et al. (2006).&nbsp;Results:&nbsp;In the assessment of the surgical scar, the parents found a difference between the three types of cleft in terms of texture, shape, and width of the scar and presence of columella deviation. The professional assessors, however, only found the three types of cleft to be different in the presence of alar flattening.&nbsp;Conclusion:&nbsp;Differences truly exist in the outcome of surgical repair of the three types of unilateral cleft lip, especially in the aesthetics of the nose and in the width and shape of the residual lip scar. Thus, it is important to consider this in the assessment of UCL repair because putting the subtypes together might have a negative impact on the assessment

    Concurrent pleomorphic adenoma in parapharyngeal space and submandibular gland

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    BACKGROUND: Pleomorphic adenoma in the parapharyngeal space either occurs de novo or as an extension from the deep lobe of the parotid gland. CASE PRESENTATION: A rare synchronous occurrence of pleomorphic adenoma in the parapharyngeal space and submandibular gland of a 48-year-old Nigerian male is reported. CONCLUSION: Pleomorphic adenoma concurrent in the parapharyngeal space and submandibular gland is very rare. A complete surgical excision of both tumors is the treatment of choice

    Multidisciplinary approach to genomics research in Africa: the AfriCRAN model

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    This article is an outcome of the African Craniofacial Anomalies Research Network (AfriCRAN) Human Hereditary and Health (H3A) grant planning meeting in 2012 in Lagos, Nigeria. It describes the strengths of a multidisciplinary team approach to solving complex genetic traits in the craniofacial region. It also highlights the different components and argues for the composition of similar teams to fast track the discovery of disease genes, diagnostic tools, improved clinical treatment and ultimately prevention of diseases
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