Designing Transdisciplinary Engineering Programmes: A New Wave in Engineering Education

Traditional engineering programmes equip graduates with knowledge and skills that enable them to achieve great technological advancements. However, one of the flaws of current programme design is that what is taught is often compartmentalised into pockets of knowledge potentially leading to a loss of perspective. Engineering students are highly applied and solution-oriented, but many times do not hold a holistic view of other associated professional dimensions. This can be detrimental in fast-paced changing environments, where they are exposed to global challenges spanning multiple disciplines. The question is how can we, as educators, overcome these flaws? We argue that providing innovative engineering education programmes that combine technical training and skills with social-scientific and policy knowledge is key. This creates the premises for new generations of graduates who possess a transdisciplinary skillset thus 'speaking multiple professional languages' and filling a clear gap on the employment market, as studies have shown. We present a case-study focused on the new engineering programme at University College London (UCL): the BSc Science and Engineering for Social Change. Here, we offer students an authentic learning experience using project and problem-based approaches to contextualise learning in diverse environments. Projects are set in collaboration with community partners who provide real-world socio-technical challenges for students to solve. Students get to simultaneously apply the technical and social science skills they learn, constituting a true transdisciplinary engineering experience enabling them to thrive in the professional world

Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition.

Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies. Here we demonstrate that treating the CEP with matrix metalloproteinase-8 (MMP-8) reduces the matrix constituents that impede solute uptake and thereby improves nutrient diffusion. Human CEP tissues harvested from four fresh cadaveric lumbar spines (age range: 38-66 years old) were treated with MMP-8. Treatment caused a dose-dependent reduction in sGAG, localized reductions to the amount of collagen, and alterations to collagen structure. These matrix modifications corresponded with 16-24% increases in the uptake of a small solute (376 Da). Interestingly, the effects of MMP-8 treatment depended on the extent of non-enzymatic glycation: treated CEPs with high concentrations of advanced glycation end products (AGEs) exhibited the lowest uptake compared to treated CEPs with low concentrations of AGEs. Moreover, AGE concentrations were donor-specific, and the donor tissues with the highest AGE concentrations appeared to have lower uptake than would be expected based on the initial amounts of collagen and sGAG. Finally, increasing solute uptake in the CEP improved cell viability inside diffusion chambers, which supports the nutritional relevance of enhancing the transport properties of the CEP. Taken together, our results provide new insights and in vitro proof-of-concept for a treatment approach that could improve disc nutrition for biologic therapy: specifically, matrix reduction by MMP-8 can enhance solute uptake and nutrient diffusion through the CEP, and AGE concentration appears to be an important, patient-specific factor that influences the efficacy of this approach

A proof of uniqueness of the Gurarii space

We present a short and elementary proof of isometric uniqueness of the Gurarii space.Comment: 6 pages, some improvements incorporate

Critical temperature of superconductor/ferromagnet bilayers

Superconductor/ferromagnet bilayers are known to exhibit nontrivial dependence of the critical temperature T_c on the thickness d_f of the ferromagnetic layer. We develop a general method for investigation of T_c as a function of the bilayer's parameters. It is shown that interference of quasiparticles makes T_c(d_f) a nonmonotonic function. The results are in good agreement with experiment. Our method also applies to multilayered structures.Comment: 4 pages, 2 EPS figures; the style file jetpl.cls is included. Version 2: typos correcte

Parton distribution functions from nonlocal light-cone operators with definite twist

We introduce the chiral-even and chiral-odd quark distributions as forward matrix elements of related bilocal quark operators with well-defined (geometric) twist. Thereby, we achieve a Lorentz invariant classification of these distributions which differ from the conventional ones by explicitly taking into account the necessary trace terms. The relations between both kinds of distribution functions are given and the mismatch between their different definition of twist is discussed. Wandzura-Wilczek--like relations between the conventional distributions (based on dynamical twist) are derived by means of geometric twist distribution functions.Comment: 17 pages, REVTEX, Extended version, The Introduction has been rewritten, Setion V "Wandzura-Wilczek--like relations" and App. B are added; Sign errors are correcte

Untangling perceptual memory: Hysteresis and adaptation map into separate cortical networks

Perception is an active inferential process in which prior knowledge is combined with sensory input, the result of which determines the contents of awareness. Accordingly, previous experience is known to help the brain "decide" what to perceive. However, a critical aspect that has not been addressed is that previous experience can exert 2 opposing effects on perception: An attractive effect, sensitizing the brain to perceive the same again (hysteresis), or a repulsive effect, making it more likely to perceive something else (adaptation). We used functional magnetic resonance imaging and modeling to elucidate how the brain entertains these 2 opposing processes, and what determines the direction of such experience-dependent perceptual effects. We found that although affecting our perception concurrently, hysteresis and adaptation map into distinct cortical networks: a widespread network of higher-order visual and fronto-parietal areas was involved in perceptual stabilization, while adaptation was confined to early visual areas. This areal and hierarchical segregation may explain how the brain maintains the balance between exploiting redundancies and staying sensitive to new information. We provide a Bayesian model that accounts for the coexistence of hysteresis and adaptation by separating their causes into 2 distinct terms: Hysteresis alters the prior, whereas adaptation changes the sensory evidence (the likelihood function)

A randomized, double-blinded trial comparing the effectiveness of tranexamic acid and epsilon-aminocaproic acid in reducing bleeding and transfusion in cardiac surgery

© 2019 Annals of Cardiac Anaesthesia. Objectives: To compare the effectiveness of epsilon aminocaproic acid (EACA) to tranexamic acid (TA) in reducing blood loss and transfusion requirements in patients undergone cardiac surgery under cardiopulmonary bypass. Design: Randomized, double blinded study. Outcome variables collected included; baseline demographic characteristics, type of surgery, amount of 24 hour chest tube drainage, amount of 24 hour blood products administered, 30 day mortality and morbidity and length of stay. We analyzed the data using parametric and non-parametric tests as appropriate. Setting: Single center tertiary-care university hospital setting. Participants: 114 patients who had undergone cardiac surgery under cardiopulmonary bypass. Interventions: Standard dose of intra-operative EACA or TA was compared in patients undergone cardiac surgery under cardiopulmonary bypass. Results: There was no statistically significant difference between groups when analyzing chest tube drainage. However, there was a significant difference in the administration of any transfusion (PRBC\u27s, FFP, platelets) intra-operatively to 24 hours postoperatively, with less transfusion in patients receiving EACA compared to TA (25% vs. 44.8%, respectively P = 0.027). Additionally, there was no significant difference in terms of adverse events during the one month follow up period. Conclusion: The findings of this study suggest that EACA and TA have similar effects on chest tube drainage but EACA is associated with fewer transfusions in CABG alone surgeries. Our results suggest that EACA can be used in a similar fashion to TA which may result in a cost and morbidity advantage

Identification of linear and nonlinear sensory processing circuits from spiking neuron data

Inferring mathematical models of sensory processing systems directly from input-output observations, while making the fewest assumptions about the model equations and the types of measurements available, is still a major issue in computational neuroscience. This letter introduces two new approaches for identifying sensory circuit models consisting of linear and nonlinear filters in series with spiking neuron models, based only on the sampled analog input to the filter and the recorded spike train output of the spiking neuron. For an ideal integrate-and-fire neuron model, the first algorithm can identify the spiking neuron parameters as well as the structure and parameters of an arbitrary nonlinear filter connected to it. The second algorithm can identify the parameters of the more general leaky integrate-and-fire spiking neuron model, as well as the parameters of an arbitrary linear filter connected to it. Numerical studies involving simulated and real experimental recordings are used to demonstrate the applicability and evaluate the performance of the proposed algorithms

THEORETICAL ASPECTS OF THE AERATION DRYING PROCESS WITH APPLICATION IN THE HAY TECHNOLOGY

In the current context of the development of mechanized agriculture in several directions in the field of feed storage needs appear in the effective implementation of the drying method used. In terms of maintaining higher production achieved by reducing losses of fodder harvesting and secondly by increasing the number of cycles of harvest due to reduced time of harvest (representing the time elapsed mowing fodder plant and to store hay), outline the need for a more careful study of the drying process. This paper presents some theoretical aspects that determine and control the drying process used in technology of hay