260 research outputs found

    Section 337 Liquidations

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    Developing An Outdoor Mindful Activity-Based Curriculum For English Language Learners

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    Many English Language Learner (ELL) students have endured trauma which inflicted deficiencies in their cognitive function. The restorative effects of nature combined with mindful activities can be employed to enhance ELL academic success and support emotional needs. This capstone project seeks to answer the question of, how can outdoor activities support the academic and emotional needs of elementary level English Language Learner students? Studies have shown that the cognitive benefits of nature included an improved ability to make decisions, a greater ability to concentrate, can foster reduced stress, and help increase positive self-esteem. Studies also confirm that comprehensive support within school systems was rarely afforded for ELL students. This outdoor mindful activity curriculum was created to support the academic and emotional needs of ELL students through outdoor mindful activities. These activities help improve cognitive function leading to improved emotional regulation and greater academic success. Research on the benefits of nature in combination with mindful activities can be the alternative instruction which can give ELL students the support they need

    The Road from Medical Injury to Claims Resolution: How No-Fault and Tort Differ

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    In the area of medical malpractice, no-fault has been offered as a response to the criticisms leveled against tort litigation for medical injuries. Five issues of no-fault are examined within the context of obstetrical malpractice

    The effect of varying target size on negative relative accommodation (NRA) and positive relative accommodation (PRA)

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    Clinical testing of negative relative accommodation (NRA) and positive relative accommodation (PRA) requires a nearpoint chart using small type. Most often, a 20/20 acuity demand is used and is considered to be the standard for these tests. Though it is understood that using different acuity demands affects the endpoints of these tests, differences have yet to be quantified for case analysis purposes. This study compares the endpoints of NRA and PRA with varying acuity demands and quantifies the differences. Fifty-six optometry students ranging in age from 22 to 38 years were tested using standard NRA and PRA test protocols on a specially constructed nearpoint card consisting of 20/20, 20/25, and 20/30 Snellen acuity lines of letters. Statistically significant differences were found in both blur-out and recovery values between each acuity demand on the NRA and PRA. Additionally, most mean values comparing monocular to binocular endpoints were statistically different. Results from this study demonstrate that different endpoints should be expected when using nonstandard targets or acuity demands for accommodative testing

    The Kinematics of Multiple-Peaked Lyα Emission in Star-Forming Galaxies at z ~ 2-3

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    We present new results on the Lyα emission-line kinematics of 18 z ~ 2-3 star-forming galaxies with multiple-peaked Lyα profiles. With our large spectroscopic database of UV-selected star-forming galaxies at these redshifts, we have determined that ~30% of such objects with detectable Lyα emission display multiple-peaked emission profiles. These profiles provide additional constraints on the escape of Lyα photons due to the rich velocity structure in the emergent line. Despite recent advances in modeling the escape of Lyα from star-forming galaxies at high redshifts, comparisons between models and data are often missing crucial observational information. Using Keck II NIRSPEC spectra of Hα (z ~ 2) and [O III]λ5007 (z ~ 3), we have measured accurate systemic redshifts, rest-frame optical nebular velocity dispersions, and emission-line fluxes for the objects in the sample. In addition, rest-frame UV luminosities and colors provide estimates of star formation rates and the degree of dust extinction. In concert with the profile sub-structure, these measurements provide critical constraints on the geometry and kinematics of interstellar gas in high-redshift galaxies. Accurate systemic redshifts allow us to translate the multiple-peaked Lyα profiles into velocity space, revealing that the majority (11/18) display double-peaked emission straddling the velocity-field zero point with stronger red-side emission. Interstellar absorption-line kinematics suggest the presence of large-scale outflows for the majority of objects in our sample, with an average measured interstellar absorption velocity offset of (Δv_(abs))=–230 km s^(–1). A comparison of the interstellar absorption kinematics for objects with multiple- and single-peaked Lyα profiles indicate that the multiple-peaked objects are characterized by significantly narrower absorption line widths. We compare our data with the predictions of simple models for outflowing and infalling gas distributions around high-redshift galaxies. While popular "shell" models provide a qualitative match with many of the observations of Lyα emission, we find that in detail there are important discrepancies between the models and data, as well as problems with applying the framework of an expanding thin shell of gas to explain high-redshift galaxy spectra. Our data highlight these inconsistencies, as well as illuminating critical elements for success in future models of outflow and infall in high-redshift galaxies

    SOFIA/EXES Observations of Water Absorption in the Protostar AFGL 2591 at High Spectral Resolution

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    We present high spectral resolution (~3 km/s) observations of the nu_2 ro-vibrational band of H2O in the 6.086--6.135 micron range toward the massive protostar AFGL 2591 using the Echelon-Cross-Echelle Spectrograph (EXES) on the Stratospheric Observatory for Infrared Astronomy (SOFIA). Ten absorption features are detected in total, with seven caused by transitions in the nu_2 band of H2O, two by transitions in the first vibrationally excited nu_2 band of H2O, and one by a transition in the nu_2 band of H2{18}O. Among the detected transitions is the nu_2 1(1,1)--0(0,0) line which probes the lowest lying rotational level of para-H2O. The stronger transitions appear to be optically thick, but reach maximum absorption at a depth of about 25%, suggesting that the background source is only partially covered by the absorbing gas, or that the absorption arises within the 6 micron emitting photosphere. Assuming a covering fraction of 25%, the H2O column density and rotational temperature that best fit the observed absorption lines are N(H2O)=(1.3+-0.3)*10^{19} cm^{-2} and T=640+-80 K.Comment: 6 pages, 3 figures, 1 table, accepted for publication in ApJ

    Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

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    Alzheimer’s disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol transport protein, apolipoprotein E (apoE), is the most common genetic risk factor for sporadic AD. In vitro evidence suggests that apoE links to Aβ production through nanoscale lipid compartments (lipid clusters), but its regulation in vivo is unclear. Here, we use superresolution imaging in the mouse brain to show that apoE utilizes astrocyte-derived cholesterol to specifically traffic neuronal amyloid precursor protein (APP) in and out of lipid clusters, where it interacts with β- and γ-secretases to generate Aβ-peptide. We find that the targeted deletion of astrocyte cholesterol synthesis robustly reduces amyloid and tau burden in a mouse model of AD. Treatment with cholesterol-free apoE or knockdown of cholesterol synthesis in astrocytes decreases cholesterol levels in cultured neurons and causes APP to traffic out of lipid clusters, where it interacts with α-secretase and gives rise to soluble APP-α (sAPP-α), a neuronal protective product of APP. Changes in cellular cholesterol have no effect on α-, β-, and γ-secretase trafficking, suggesting that the ratio of Aβ to sAPP-α is regulated by the trafficking of the substrate, not the enzymes. We conclude that cholesterol is kept low in neurons, which inhibits Aβ accumulation and enables the astrocyte regulation of Aβ accumulation by cholesterol signaling

    Strong Nebular Line Ratios in the Spectra of z~2-3 Star-forming Galaxies: First Results from KBSS-MOSFIRE

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    We present initial results of a deep near-IR spectroscopic survey covering the 15 fields of the Keck Baryonic Structure Survey (KBSS) using MOSFIRE on the Keck 1 telescope, focusing on a sample of 251 galaxies with redshifts 2.0< z < 2.6, star-formation rates 2 < SFR < 200 M_sun/yr, and stellar masses 8.6 < log(M*/M_sun) < 11.4, with high-quality spectra in both H- and K-band atmospheric windows. We show unambiguously that the locus of z~2.3 galaxies in the "BPT" nebular diagnostic diagram exhibits a disjoint, yet similarly tight, relationship between the ratios [NII]6585/Halpha and [OIII]/Hbeta as compared to local galaxies. Using photoionization models, we argue that the offset of the z~2.3 locus relative to z~ 0 is explained by a combination of harder ionizing radiation field, higher ionization parameter, and higher N/O at a given O/H than applies to most local galaxies, and that the position of a galaxy along the z~2.3 star-forming BPT locus is surprisingly insensitive to gas-phase oxygen abundance. The observed nebular emission line ratios are most easily reproduced by models in which the net ionizing radiation field resembles a blackbody with effective temperature T_eff = 50000-60000 K and N/O close to the solar value at all O/H. We critically assess the applicability of commonly-used strong line indices for estimating gas-phase metallicities, and consider the implications of the small intrinsic scatter in the empirical relationship between excitation-sensitive line indices and stellar mass (i.e., the "mass-metallicity" relation), at z~2.3.Comment: 41 pages, 25 figures, accepted for publication in the Astrophysical Journal. Version with full-resolution figures available at http://www.astro.caltech.edu/~ccs/mos_bpt_submit.pd

    The Exemplar T8 Subdwarf Companion of Wolf 1130

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    We have discovered a wide separation (188.5") T8 subdwarf companion to the sdM1.5+WD binary Wolf 1130. Companionship of WISE J200520.38+542433.9 is verified through common proper motion over a ~3 year baseline. Wolf 1130 is located 15.83 +/- 0.96 parsecs from the Sun, placing the brown dwarf at a projected separation of ~3000 AU. Near-infrared colors and medium resolution (R~2000-4000) spectroscopy establish the uniqueness of this system as a high-gravity, low-metallicity benchmark. Although there are a number of low-metallicity T dwarfs in the literature, WISE J200520.38+542433.9 has the most extreme inferred metallicity to date with [Fe/H] = -0.64 +/- 0.17 based on Wolf 1130. Model comparisons to this exemplar late-type subdwarf support it having an old age, a low metallicity, and a small radius. However, the spectroscopic peculiarities of WISE J200520.38+542433.9 underscore the importance of developing the low-metallicity parameter space of the most current atmospheric models.Comment: Accepted to ApJ on 05 September 2013; 33 pages in preprint format, 8 figures, 3 table
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