Epstein-Barr-negative MS: a true phenomenon?

This work was supported by institutional funding and in part by the BMBF grant KKNMS (Competence Net Multiple Sclerosis) to H Tumani

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

none99siBackground Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls. Methods We investigated serum NfL levels in 100 patients with CIS with a short conversion interval to clinically definite multiple sclerosis (MS) (fast converters (FC), median (IQR) conversion time: 110 days (79-139)); 98 patients with non-converting CIS (non-converters (NC), follow-up: 6.5 years (5.3-7.9)); and 92 healthy controls. Results NfL levels were higher in FC (24.1 pg/mL (13.5-51.8)) and NC (19.3 pg/mL (13.6-35.2)) than in healthy controls (7.9 pg/mL (5.6-17.2)) (OR=5.85; 95% CI 2.63 to 13.02; p=1.5×10-5 and OR=7.03; 95% CI 2.85 to 17.34; p=2.3×10-5, respectively). When grouping FC and NC, increased serum NfL concentration was also associated with increasing numbers of T2 hyperintense MRI lesions (OR=2.36; 95% CI 1.21 to 4.59; p=0.011), gadolinium-enhancing lesions (OR=2.69; 95% CI 1.13 to 6.41; p=0.026) and higher disability scores (OR=2.54; 95% CI 1.21 to 5.31; p=0.013) at CIS diagnosis. Conclusions If replicated in future studies, serum NfL may represent a reliable and easily accessible biomarker of early axonal damage in CIS and MS.restrictedDisanto G1, Adiutori R2, Dobson R2, Martinelli V3, Dalla Costa G3, Runia T4, Evdoshenko E5, Thouvenot E6, Trojano M7, Norgren N8, Teunissen C9, Kappos L10, Giovannoni G2, Kuhle J, Bianchi L, Topping J, Bestwick JP, Meier UC, , Lazareva N, Iaffaldano P, Direnzo V, Khademi M, Piehl F, Comabella M, Sombekke M, Killestein J, Hegen H, Rauch S, D'Alfonso S, Alvarez-Cermeño JC, Kleinová P, Horáková D, Roesler R, Lauda F, Llufriu S, Avsar T, Uygunoglu U, Altintas A, Saip S, Menge T, Rajda C, Bergamaschi R, Moll N, Khalil M, Marignier R, Dujmovic I, Larsson H, Malmestrom C, Scarpini E, Fenoglio C, Wergeland S, Laroni A, Annibali V, Romano S, Martínez AD, Carra A, Salvetti M, Uccelli A, Torkildsen Ø, Myhr KM, Galimberti D, Rejdak K, Lycke J, Frederiksen JL, Drulovic J, Confavreux C, Brassat D, Enzinger C, Fuchs S, Bosca I, Pelletier J, Picard C, Colombo E, Franciotta D, Derfuss T, Lindberg RL, Yaldizli Ö, Vécsei L, Kieseier BC, Hartung HP, Villoslada P, Siva A, Saiz A, Tumani H, Havrdová E, Villar LM, Leone M, Barizzone N, Deisenhammer F, Montalban X, Tintoré M, Olsson T, Lehmann S, Castelnovo G, Lapin S, Hintzen R, Furlan R, Comi G, Ramagopalan SV.Disanto, G1; Adiutori, R2; Dobson, R2; Martinelli, V3; Dalla Costa, G3; Runia, T4; Evdoshenko, E5; Thouvenot, E6; Trojano, M7; Norgren, N8; Teunissen, C9; Kappos, L10; Giovannoni, G2; Kuhle, J; Bianchi, L; Topping, J; Bestwick, Jp; Meier, Uc; Lazareva, N; Iaffaldano, P; Direnzo, V; Khademi, M; Piehl, F; Comabella, M; Sombekke, M; Killestein, J; Hegen, H; Rauch, S; D'Alfonso, S; Alvarez-Cermeño, Jc; Kleinová, P; Horáková, D; Roesler, R; Lauda, F; Llufriu, S; Avsar, T; Uygunoglu, U; Altintas, A; Saip, S; Menge, T; Rajda, C; Bergamaschi, R; Moll, N; Khalil, M; Marignier, R; Dujmovic, I; Larsson, H; Malmestrom, C; Scarpini, E; Fenoglio, C; Wergeland, S; Laroni, A; Annibali, V; Romano, S; Martínez, Ad; Carra, A; Salvetti, M; Uccelli, A; Torkildsen, Ø; Myhr, Km; Galimberti, D; Rejdak, K; Lycke, J; Frederiksen, Jl; Drulovic, J; Confavreux, C; Brassat, D; Enzinger, C; Fuchs, S; Bosca, I; Pelletier, J; Picard, C; Colombo, E; Franciotta, D; Derfuss, T; Lindberg, Rl; Yaldizli, Ö; Vécsei, L; Kieseier, Bc; Hartung, Hp; Villoslada, P; Siva, A; Saiz, A; Tumani, H; Havrdová, E; Villar, Lm; Leone, M; Barizzone, N; Deisenhammer, F; Montalban, X; Tintoré, M; Olsson, T; Lehmann, S; Castelnovo, G; Lapin, S; Hintzen, R; Furlan, R; Comi, G; Ramagopalan, Sv