73 research outputs found
Tunable temperature induced magnetization jump in a GdVO3 single crystal
We report a novel feature of the temperature induced magnetization jump
observed along the a-axis of the GdVO3 single crystal at temperature TM = 0.8
K. Below TM, the compound shows no coercivity and remanent magnetization
indicating a homogenous antiferromagnetic structure. However, we will
demonstrate that the magnetic state below TM is indeed history dependent and it
shows up in different jumps in the magnetization only when warming the sample
through TM. Such a magnetic memory effect is highly unusual and suggesting
different domain arrangements in the supposedly homogenous antiferromagnetic
phase of the compound.Comment: 17 pages, 8 Figure
Phase Behavior of Complementary Multiply Hydrogen Bonded End-Functional Polymer Blends
Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp.
The tumor microenvironment is a nutrient-deficient region that alters the cancer cell phenotype to aggravate cancer pathology. The ability of cancer cells to tolerate nutrient starvation is referred to as austerity. Compounds that preferentially target cancer cells growing under nutrient-deficient conditions are being employed in anti-austerity approaches in anticancer drug discovery. Therefore, in this study, we investigated physcion (1) and 2-(2′,3-epoxy-1′,3′,5′-heptatrienyl)-6-hydroxy-5-(3-methyl-2-butenyl) benzaldehyde (2) obtained from a culture extract of the marine-derived fungus Aspergillus species (sp.), which were isolated from an unidentified marine sponge, as anti-austerity agents. The chemical structures of 1 and 2 were determined via spectroscopic analysis and comparison with authentic spectral data. Compounds 1 and 2 exhibited selective cytotoxicity against human pancreatic carcinoma PANC-1 cells cultured under glucose-deficient conditions, with IC50 values of 6.0 and 1.7 µM, respectively. Compound 2 showed higher selective growth-inhibitory activity (505-fold higher) under glucose-deficient conditions than under general culture conditions. Further analysis of the mechanism underlying the anti-austerity activity of compounds 1 and 2 against glucose-starved PANC-1 cells suggested that they inhibited the mitochondrial electron transport chain
Time-Resolved High-Resolution SAXS Studies of OOT Process and Mechanism from Hex-Cylinder to BCC-Sphere in a Polystyrene- block
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