The key aspects of innovation-oriented regional industrial and economic policy

Integration processes taking place in the economy, the new requirements to enhance the effectiveness of production during international competition as well as the need to ensure the social conditions lead to the development and implementation of innovation-oriented regional industrial and economic policy, which in its turn, requires adopting substantial organizational and economic recommendations

Nonperturbative Approach to Circuit Quantum Electrodynamics

We outline a rigorous method which can be used to solve the many-body Schroedinger equation for a Coulomb interacting electronic system in an external classical magnetic field as well as a quantized electromagnetic field. Effects of the geometry of the electronic system as well as the polarization of the quantized electromagnetic field are explicitly taken into account. We accomplish this by performing repeated truncations of many-body spaces in order to keep the size of the many particle basis on a manageable level. The electron-electron and electron-photon interactions are treated in a nonperturbative manner using "exact numerical diagonalization". Our results demonstrate that including the diamagnetic term in the photon-electron interaction Hamiltonian drastically improves numerical convergence. Additionally, convergence with respect to the number of photon states in the joint photon-electron Fock space basis is fast. However, the convergence with respect to the number of electronic states is slow and is the main bottleneck in calculations.Comment: Revtex, pdflatex, 8 pages, with 5 included pdf figure

Agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula in the Reykjavik eye study.

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldPURPOSE: To establish the agreement between image grading of conventional (45°) and ultra wide-angle (200°) digital images in the macula. METHODS: In 2008, the 12-year follow-up was conducted on 573 participants of the Reykjavik Eye Study. This study included the use of the Optos P200C AF ultra wide-angle laser scanning ophthalmoscope alongside Zeiss FF 450 conventional digital fundus camera on 121 eyes with or without age-related macular degeneration using the International Classification System. Of these eyes, detailed grading was carried out on five cases each with hard drusen, geographic atrophy and chorioretinal neovascularisation, and six cases of soft drusen. Exact agreement and κ-statistics were calculated. RESULTS: Comparison of the conventional and ultra wide-angle images in the macula showed an overall 96.43% agreement (κ=0.93) with no disagreement at end-stage disease; although in one eye chorioretinal neovascularisation was graded as drusenoid pigment epithelial detachment. Of patients with drusen only, the exact agreement was 96.1%. The detailed grading showed no clinically significant disagreement between the conventional 45° and 200° images. CONCLUSIONS: On the basis of our results, there is a good agreement between grading conventional and ultra wide-angle images in the macul

Ectopic Cushing Syndrome Due to Colon Cancer With Dual Morphology

Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinnWe report a case of colon cancer, and the most interesting presentation was Cushing’s syndrome (CS). A 72-year-old woman was diagnosed with CS when admitted to hospital because of NSTEMI and heart failure. The patient succumbed to her illness only 4 weeks after presentation. The colon cancer was a combined adenocarcinoma and small cell carcinoma, solely the latter component responsible for producing adrenocorticotropin hormone (ACTH)

Percolation in invariant Poisson graphs with i.i.d. degrees

Let each point of a homogeneous Poisson process in R^d independently be equipped with a random number of stubs (half-edges) according to a given probability distribution mu on the positive integers. We consider translation-invariant schemes for perfectly matching the stubs to obtain a simple graph with degree distribution mu. Leaving aside degenerate cases, we prove that for any mu there exist schemes that give only finite components as well as schemes that give infinite components. For a particular matching scheme that is a natural extension of Gale-Shapley stable marriage, we give sufficient conditions on mu for the absence and presence of infinite components

Design and development of a low temperature, inductance based high frequency ac susceptometer

We report on the development of an induction based low temperature high frequency ac susceptometer capable of measuring at frequencies up to 3.5 MHz and at temperatures between 2 K and 300 K. Careful balancing of the detection coils and calibration have allowed a sample magnetic moment resolution of $5\times10^{-10} Am^2$ at 1 MHz. We will discuss the design and characterization of the susceptometer, and explain the calibration process. We also include some example measurements on the spin ice material CdEr$_2$S$_4$ and iron oxide based nanoparticles to illustrate functionality

Evaluation of a Commercial Enzyme Linked Immunosorbent Assay (ELISA) for the Determination of the Neurotoxin BMAA in Surface Waters

The neurotoxin ß-N-methylamino-L-alanine (BMAA) is suspected to play a role in Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. Because BMAA seems to be produced by cyanobacteria, surface waters are screened for BMAA. However, reliable analysis of BMAA requires specialized and expensive equipment. In 2012, a commercial enzyme-linked immunosorbent assay (ELISA) for determination of BMAA in surface waters was released. This kit could enable fast and relatively cheap screening of surface waters for BMAA. The objective of this study was to determine whether the BMAA ELISA kit was suitable for the determination of BMAA concentrations in surface waters. We hypothesised that the recovery of spiked samples was close to 100% and that the results of unspiked sample analysis were comparable between ELISA and liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis. However, we found that recovery was higher than 100% in most spiked samples, highest determined recovery was over 400%. Furthermore, the ELISA gave a positive signal for nearly each tested sample while no BMAA could be detected by LC-MS/MS. We therefore conclude that in its current state, the kit is not suitable for screening surface waters for BMAA

Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity

The complex of coagulation factor VIIa (FVIIa), a trypsin-like serine protease, and membrane-bound tissue factor (TF) initiates blood coagulation upon vascular injury. Binding of TF to FVIIa promotes allosteric conformational changes in the FVIIa protease domain and improves its catalytic properties. Extensive studies have revealed two putative pathways for this allosteric communication. Here we provide further details of this allosteric communication by investigating FVIIa loop swap variants containing the 170 loop of trypsin that display TF-independent enhanced activity. Using x-ray crystallography, we show that the introduced 170 loop from trypsin directly interacts with the FVIIa active site, stabilizing segment 215–217 and activation loop 3, leading to enhanced activity. Molecular dynamics simulations and novel fluorescence quenching studies support that segment 215–217 conformation is pivotal to the enhanced activity of the FVIIa variants. We speculate that the allosteric regulation of FVIIa activity by TF binding follows a similar path in conjunction with protease domain N terminus insertion, suggesting a more complete molecular basis of TF-mediated allosteric enhancement of FVIIa activity

Fragility of the Free-Energy Landscape of a Directed Polymer in Random Media

We examine the sensitiveness of the free-energy landscape of a directed polymer in random media with respect to various kinds of infinitesimally weak perturbation including the intriguing case of temperature-chaos. To this end, we combine the replica Bethe ansatz approach outlined in cond-mat/0112384, the mapping to a modified Sinai model and numerically exact calculations by the transfer-matrix method. Our results imply that for all the perturbations under study there is a slow crossover from a weakly perturbed regime where rare events take place to a strongly perturbed regime at larger length scales beyond the so called overlap length where typical events take place leading to chaos, i.e. a complete reshuffling of the free-energy landscape. Within the replica space, the evidence for chaos is found in the factorization of the replicated partition function induced by infinitesimal perturbations. This is the reflex of explicit replica symmetry breaking.Comment: 29 pages, Revtex4, ps figure