42 research outputs found
Small-sample corrections for score tests in Birnbaum-Saunders regressions
In this paper we deal with the issue of performing accurate small-sample
inference in the Birnbaum-Saunders regression model, which can be useful for
modeling lifetime or reliability data. We derive a Bartlett-type correction for
the score test and numerically compare the corrected test with the usual score
test, the likelihood ratio test and its Bartlett-corrected version. Our
simulation results suggest that the corrected test we propose is more reliable
than the other tests.Comment: To appear in the Communications in Statistics - Theory and Methods,
http://www.informaworld.com/smpp/title~content=t71359723
The local power of the gradient test
The asymptotic expansion of the distribution of the gradient test statistic
is derived for a composite hypothesis under a sequence of Pitman alternative
hypotheses converging to the null hypothesis at rate , being the
sample size. Comparisons of the local powers of the gradient, likelihood ratio,
Wald and score tests reveal no uniform superiority property. The power
performance of all four criteria in one-parameter exponential family is
examined.Comment: To appear in the Annals of the Institute of Statistical Mathematics,
this http://www.ism.ac.jp/editsec/aism-e.htm
Parameter induction in continuous univariate distributions: Well-established G families
Bivariate Kumaraswamy distribution: properties and a new method to generate bivariate classes
Goodness of fit tests of the two-parameter gamma distribution against the three-parameter generalized gamma distribution
Detection of Histoplasma Antigen by a Quantitative Enzyme Immunoassay▿
The second-generation Histoplasma antigen immunoassay is semiquantitative, expressing results as a comparison to a negative control, which requires repeat testing of the prior specimen with the current specimen to accurately determine a change in antigen. Reporting results in this manner often is confusing to the ordering physician and laboratory. Development of a quantitative assay could improve accuracy, reduce interassay variability, and eliminate the need to test the prior sample with the current sample in the same assay. Calibrators with known concentrations of Histoplasma antigen were used to quantitate antigen in specimens from patients with histoplasmosis and from controls. Samples from cases of disseminated histoplasmosis or other mycoses and controls were tested to evaluate the performance characteristics of the quantitative assay. Paired specimens were evaluated to determine if quantitation eliminated the need to test the current and prior specimens in the same assay to assess a change in antigen. The sensitivity in samples from patients with AIDS and disseminated histoplasmosis was 100% in urine and 92.3% in serum. Cross-reactions occurred in 70% of other endemic mycoses, but not in aspergillosis. Specificity was 99% in controls with community-acquired pneumonia, medical conditions in which histoplasmosis was excluded, or healthy subjects. A change in antigen level categorized as an increase, no change, or decrease based on antigen units determined in the same assay agreed closely with the category of change in nanograms/milliliter determined from testing current and prior specimens in different assays. Sensitivity, specificity, and interassay precision are excellent in the new third-generation quantitative Histoplasma antigen immunoassay