Replica Method for Wide Correlators in Gaussian Orthogonal, Unitary And Symplectic Random Matrix Ensembles

We calculate connected correlators in Gaussian orthogonal, unitary and symplectic random matrix ensembles by the replica method in the 1/N-expansion. We obtain averaged one-point Green's functions up to the next-to-leading order O(1/N) and wide two-level correlators up to the first nontrivial order O(1/N^2) and wide three-level correlators up to the first nontrivial order $O(1/N^4)$ by carefully treating fluctuations in saddle-point evaluation.Comment: LaTeX 21 pages, a new result on wide three-level correlators adde

Phase diagram of a 1 dimensional spin-orbital model

We study a 1 dimensional spin-orbital model using both analytical and numerical methods. Renormalization group calculations are performed in the vicinity of a special integrable point in the phase diagram with SU(4) symmetry. These indicate the existence of a gapless phase in an extended region of the phase diagram, missed in previous studies. This phase is SU(4) invariant at low energies apart from the presence of different velocities for spin and orbital degrees of freedom. The phase transition into a gapped dimerized phase is in a generalized Kosterlitz-Thouless universality class. The phase diagram of this model is sketched using the density matrix renormalization group technique.Comment: 11 pages, 5 figures, new references adde

Epigenetic regulation of interleukin-8, an inflammatory chemokine, in osteoarthritis

SummaryObjectiveTo determine whether altered IL8 methylation status is associated with increased expression of IL8 in human osteoarthritic (OA) chondrocytes.MethodsIL8 expression levels and the percentage CpG methylation in human chondrocytes were quantified by qRT-PCR and pyrosequencing in OA patients and in non-OA osteoporotic controls. The effect of CpG methylation on IL8 promoter activity was determined using a CpG-free vector; co-transfections with expression vectors encoding nuclear factor-kappa B (NF-κB), AP-1 and C/EBP were subsequently undertaken to analyse for IL8 promoter activity in response to changes in methylation status.ResultsIL8 expression in OA patients was 37-fold higher than in osteoporotic controls. Three CpG sites in the IL8 promoter were significantly demethylated in OA patients. Multiple regression analysis revealed that the degree of methylation of the CpG site located at −116-bp was the strongest predictor of IL8 expression. In vitro DNA methylation was noted to decrease IL8 promoter basal activity. Furthermore, NF-κB, AP-1 and C/EBP strongly enhanced IL8 promoter activity whilst DNA methylation inhibited the effects of these three transcription factors.ConclusionsThe present study demonstrates the key role of DNA methylation status on the expression of IL8 in human chondrocytes. We demonstrate a quantitative relationship between percentage methylation and gene expression within clinical samples. These studies provide direct evidence linking the activation of IL8, DNA demethylation and the induction of the OA process with important therapeutic implications therein for patients with this debilitating disease

Quantum phase transitions of the asymmetric three-leg spin tube

We investigate quantum phase transitions of the S=1/2 three-leg antiferromagnetic spin tube with asymmetric inter-chain (rung) exchange interactions. On the basis of the electron tube system, we propose a useful effective theory to give the global phase diagram of the asymmetric spin tube. In addition, using other effective theories we raise the reliability of the phase diagram. The density-matrix renormalization-group and the numerical diagonalization analyses show that the finite spin gap appears in a narrow region around the rung-symmetric line, in contrast to a recent paper by Nishimoto and Arikawa [Phys. Rev. B78, 054421 (2008)]. The numerical calculations indicate that this global phase diagram obtained by use of the effective theories is qualitatively correct. In the gapless phase on the phase diagram, the numerical data are fitted by a finite-size scaling in the c=1 conformal field theory. We argue that all the phase transitions between the gapful and gapless phases belong to the Berezinskii-Kosterlitz-Thouless universality class.Comment: 12 pages, 7 figures, 2 column, final versio

On gonihedric loops and quantum gravity

We present an analysis of the gonihedric loop model, a reformulation of the two dimensional gonihedric spin model, using two different techniques. First, the usual regular lattice statistical physics problem is mapped onto a height model and studied analytically. Second, the gravitational version of this loop model is studied via matrix models techniques. Both methods lead to the conclusion that the model has $c_{matter}=0$ for all values of the parameters of the model. In this way it is possible to understand the absence of a continuous transition

Gapless Excitation above a Domain Wall Ground State in a Flat Band Hubbard Model

We construct a set of exact ground states with a localized ferromagnetic domain wall and with an extended spiral structure in a deformed flat-band Hubbard model in arbitrary dimensions. We show the uniqueness of the ground state for the half-filled lowest band in a fixed magnetization subspace. The ground states with these structures are degenerate with all-spin-up or all-spin-down states under the open boundary condition. We represent a spin one-point function in terms of local electron number density, and find the domain wall structure in our model. We show the existence of gapless excitations above a domain wall ground state in dimensions higher than one. On the other hand, under the periodic boundary condition, the ground state is the all-spin-up or all-spin-down state. We show that the spin-wave excitation above the all-spin-up or -down state has an energy gap because of the anisotropy.Comment: 26 pages, 1 figure. Typos are fixe

An asymptotic formula for marginal running coupling constants and universality of loglog corrections

Given a two-loop beta function for multiple marginal coupling constants, we derive an asymptotic formula for the running coupling constants driven to an infrared fixed point. It can play an important role in universal loglog corrections to physical quantities.Comment: 16 pages; typos fixed, one appendix removed for quick access to the main result; to be published in J. Phys.

Smooth Paths on Three Dimensional Lattice

A particular class of random walks with a spin factor on a three dimensional cubic lattice is studied. This three dimensional random walk model is a simple generalization of random walk for the two dimensional Ising model. All critical diffusion constants and associated critical exponents are calculated. Continuum field theories such as Klein-Gordon, Dirac and massive Chern-Simons theories are constructed near several critical points.Comment: 7 pages,NUP-A-94-