Comparison of four mathematical models to analyze indicator-dilution curves in the coronary circulation

While several models have proven to result in accurate estimations when measuring cardiac output using indicator dilution, the mono-exponential model has primarily been chosen for deriving coronary blood/plasma volume. In this study, we compared four models to derive coronary plasma volume using indicator dilution; the mono-exponential, power-law, gamma-variate, and local density random walk (LDRW) model. In anesthetized goats (N = 14), we determined the distribution volume of high molecular weight (2,000 kDa) dextrans. A bolus injection (1.0 ml, 0.65 mg/ml) was given intracoronary and coronary venous blood samples were taken every 0.5–1.0 s; outflow curves were analyzed using the four aforementioned models. Measurements were done at baseline and during adenosine infusion. Absolute coronary plasma volume estimates varied by ~25% between models, while the relative volume increase during adenosine infusion was similar for all models. The gamma-variate, LDRW, and mono-exponential model resulted in volumes corresponding with literature, whereas the power-model seemed to overestimate the coronary plasma volume. The gamma-variate and LDRW model appear to be suitable alternative models to the mono-exponential model to analyze coronary indicator-dilution curves, particularly since these models are minimally influenced by outliers and do not depend on data of the descending slope of the curve only

Atmospheric CO2 concentration from 60 to 20 kyr BP from the Taylor Dome ice core, Antarctica

A high-resolution record of the atmospheric CO2 concentration from 60 to 20 thousand years before present (kyr BP) based on measurements on the ice core of Taylor Dome, Antarctica is presented. This record shows four distinct peaks of 20 parts per million by volume (ppmv) on a millennial time scale. Good correlation of the CO2 record with temperature reconstructions based on stable isotope measurements on the Vostok ice core (Antarctica) is found

Timing of the Antarctic cold reversal and the atmospheric CO₂ increase with respect to the Younger Dryas event

The transition from the Last Glacial to the Holocene is a key period for understanding the mechanisms of global climate change. Ice cores from the large polar ice sheets provide a wealth of information with good time resolution for this period. However, interactions between the two hemispheres can only be investigated if ice core records from Greenland and Antarctica can be synchronised accurately and reliably. The atmospheric methane concentration shows large and very fast changes during this period. These variations are well suited for a synchronisation of the age scales of ice cores from Greenland and Antarctica. Here we confirm the proposed lead of the Antarctic Cold Reversal on the Younger Dryas cold event. The Antarctic cooling precedes the Younger Dryas by at least 1.8 kyr. This suggests that northern and southern hemispheres were in anti-phase during the Younger Dryas cold event. A further result of the synchronisation is that the long-term glacial-interglacial increase of atmospheric CO2 was not interrupted during the Younger Dryas event and that atmospheric CO2 changes are not necessarily dominated by changes in the North Atlantic circulation

Timing of the Antarctic Cold Reversal and the atmospheric CO2 increase with respect to the Younger Dryas event

The transition from the Last Glacial to the Holocene is a key period for understanding the mechanisms of global climate change. Ice cores from the large polar ice sheets provide a wealth of information with good time resolution for this period. However, interactions between the two hemispheres can only be investigated if ice core records from Greenland and Antarctica can be synchronised accurately and reliably. The atmospheric methane concentration shows large and very fast changes during this period. These variations are well suited for a synchronisation of the age scales of ice cores from Greenland and Antarctica. Here we confirm the proposed lead of the Antarctic Cold Reversal on the Younger Dryas cold event. The Antarctic cooling precedes the Younger Dryas by at least l.8 kyr. This suggests that northern and southern hemispheres were in anti-phase during the Younger Dryas cold event. A further result of the synchronisation is that the long-term glacial-interglacial increase of atmospheric CO2 was not interrupted during the Younger Dryas event and that atmospheric CO2 changes are not necessarily dominated by changes in the North Atlantic circulation. Copyright 1997 by the American Geophysical Union