Isolation, Characterization of dihydroflavonol from Coriandrum sativum Seeds

         تم فصل أول مركب فلافوني من بذور نبات الكزبرة ذو الأهمية الطبية .  المستخلص الكحولي أعطي المركب : 7 ، 5  ثنائي  هيدروكسيل - ׳ 5 ميثوكسيل  ثنائي هيدروالفلافونول ، والذي حددت تركيبته بواسطة  طيف الأشعة  تحت   الحمراء ، طيف الأشعة  فوق البنفسجية ، طيف الرنين النووي المغنطيسي و طيف الكتلة .                               The authors report on the first isolation of a flavone from the seeds of the medicinally important plant Coriandrum sativum (Apiaceae) . Chromatographic fractionation of the ethanolic extract gave flavonoid (C1) : 5,7,–dihydroxy-5׳- methoxy dihydroflavonol.The structure of this compound was elucidated on the basis of its IR, UV,1H NMR and MS.     &nbsp

Charge-transfer interaction of drug quinidine with quinol, picric acid and DDQ: Spectroscopic characterization and biological activity studies towards understanding the drugâreceptor mechanism

Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drugâreceptor binding mechanism. Structural, thermal, morphological and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis; infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD); thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form. Keywords: Quinidine, Charge-transfer interaction, Powder X-ray diffraction, Morphology, Thermal analysi