Analysis and imaging of biocidal agrochemicals using ToF-SIMS

ToF-SIMS has been increasingly widely used in recent years to look at biological matrices, in particular for biomedical research, although there is still a lot of development needed to maximise the value of this technique in the life sciences. The main issue for biological matrices is the complexity of the mass spectra and therefore the difficulty to specifically and precisely detect analytes in the biological sample. Here we evaluated the use of ToF-SIMS in the agrochemical field, which remains a largely unexplored area for this technique. We profiled a large number of biocidal active ingredients (herbicides, fungicides, and insecticides); we then selected fludioxonil, a halogenated fungicide, as a model compound for more detailed study, including the effect of co-occurring biomolecules on detection limits. There was a wide range of sensitivity of the ToF-SIMS for the different active ingredient compounds, but fludioxonil was readily detected in real-world samples (wheat seeds coated with a commercial formulation). Fludioxonil did not penetrate the seed to any great depth, but was largely restricted to a layer coating the seed surface. ToF-SIMS has clear potential as a tool for not only detecting biocides in biological samples, but also mapping their distribution

Implementation and validation of a new method to model voluntary departures from emergency departments

In the literature, several organizational solutions have been proposed for determining the probability of voluntary patient discharge from the emergency department. Here, the issue of self-discharge is analyzed by Markov theory-based modeling, an innovative approach diffusely applied in the healthcare field in recent years. The aim of this work is to propose a new method for calculating the rate of voluntary discharge by defining a generic model to describe the process of first aid using a “behavioral” Markov chain model, a new approach that takes into account the satisfaction of the patient. The proposed model is then implemented in MATLAB and validated with a real case study from the hospital “A. Cardarelli” of Naples. It is found that most of the risk of self-discharge occurs during the wait time before the patient is seen and during the wait time for the final report; usually, once the analysis is requested, the patient, although not very satisfied, is willing to wait longer for the results. The model allows the description of the first aid process from the perspective of the patient. The presented model is generic and can be adapted to each hospital facility by changing only the transition probabilities between states

Agile six sigma in healthcare: Case study at santobono pediatric hospital

Healthcare is one of the most complex systems to manage. In recent years, the control of processes and the modelling of public administrations have been considered some of the main areas of interest in management. In particular, one of the most problematic issues is the management of waiting lists and the consequent absenteeism of patients. Patient no-shows imply a loss of time and resources, and in this paper, the strategy of overbooking is analysed as a solution. Here, a real waiting list process is simulated with discrete event simulation (DES) software, and the activities performed by hospital staff are reproduced. The methodology employed combines agile manufacturing and Six Sigma, focusing on a paediatric public hospital pavilion. Different scenarios show that the overbooking strategy is effective in ensuring fairness of access to services. Indeed, all patients respect the times dictated by the waiting list, without “favouritism”, which is guaranteed by the logic of replacement. In a comparison between a real sample of bookings and a simulated sample designed to improve no-shows, no statistically significant difference is found. This model will allow health managers to provide patients with faster service and to better manage their resources. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Foreign Direct Investment in Post-Conflict Countries: The Case of Iraq's Oil and Electricity Sectors

Foreign direct investment is new phenomenon to Iraq, a post conflict country with abundance of natural resources. With dominant state-controlled public sector, attracting foreign investment is an added challenge to an economy devastated by years of wars. A qualitative case study was conducted to assess determinants of foreign direct investment in Iraq’s energy sector. Data was collected from interviews with business and government subject matter experts, and a review of publically available documents. Lack of security, political instability, corruption, and inadequate government policies towards foreign direct investment as symptoms found and typically shared by other post-conflict countries. The persistence of violence was not seen as a deterrent; however, foreign direct investment activity in the energy sector was virtually limited to the semi-autonomous region of Kurdistan. Investments were either wholly-owned or joint-venture enterprises. Implications to other post conflict countries, using Kuwait and Nigeria as illustrative examples, are presented and recommendations made. Keywords: Foreign direct investment; Iraq; post-conflict country; energy JEL Classifications: F21; F23; O53; P28