Sensor impedimétrico para la detección de bacterias patogénicas mediante péptidos antimicrobianos

Áccesit Congreso SIBB 2015La peri-implantitis, una inflamación causada por la formación del biofilm, es una de las causas más importantes de la fallida de los implantes en odontología. Por esto, la detección de bacterias patogénicas al inicio del proceso de formación de biofilms, representa una estrategia muy potente para la prevención de las infecciones en los implantes. Entre los diferentes métodos para la detección de bacterias patogénicas, los biosensores electroquímicos, especialmente los sistemas basados en impedancia (EIS), presentan una serie de ventajas como la miniaturización, la mejora en sensibilidad y el bajo coste. En este sentido, los péptidos antimicrobianos (AMPs), conocidos como componentes del sistema inmune y con actividad hacia las bacterias, pueden ser usados para desarrollar elementos de bioreconocimiento altamente efectivos. Por lo tanto, el objetivo de este estudio es la combinación del uso de EIS y la habilidad de los AMPs para obtener biosensores con alta sensibilidad, especificidad y límites de detección muy bajos para la detección de bacterias patogénicas.Peer ReviewedAward-winnin

Experimental and numerical analyses of microstructure evolution of Cu-Cr-Zr alloys during severe plastic deformation

We have performed a constitutive experimental, FEM and discrete complex based studies for two copper alloys subjected to ECAP and MDF deformation processes. This combination of methods allows for recognising complementary microstructural effects, such as micro- and macrolocalization phenomena, coupled dislocation cells and grains evolution, inhomogeneities of triple junction network and ultrafine grain emergenc

Grain refinement kinetics in a low alloyed Cu-Cr-Zr alloy subjected to large strain deformation

This paper investigates the microstructural evolution and grain refinement kinetics of a solution-treated Cu-0.1Cr-0.06Zr alloy during equal channel angular pressing (ECAP) at a temperature of 673 K via route BC. The microstructural change during plastic deformation was accompanied by the formation of the microband and an increase in the misorientations of strain-induced subboundarie

CHOOSING FREE TRANSPLANTS FOR PLASTIC SURGERY OF THE SCAR-DEFORMED TISSUE OF EYELIDS AND IN THE PERIORBITAL AREA ON THE BASIS OF BIOMECHANICAL CRITERIA

Purpose. The paper reports the results of a comparative study of strength-elastic properties of the skin of the upper and lower eyelids, eyebrows, conjunctiva as well as those of free transplants (excess skin of the upper eyelid, skin of the posterior surface of the auricle, the inner surface of the shoulder, the lip mucosa) in normal conditions and scar deformations. Material and methods. In the study 210 standard-size samples were cut from tissues removed during reconstructive plastic surgeries of traumas and burns of the eye and eye adnexa. In order to determine the biomechanical parameters, the samples were loaded until a rupture using the Autograph Universal Testing Machine (Shimadzu, Japan) and checked for the tension-deformation dependence. This dependence was used to calculate the elasticity modulus, the tensile strength, and the maximum longitudinal deformation of the examined tissue. Results. The obtained results revealed differences in strength-elastic parameters of the skin of the upper and the lower eyelids and also the eyebrow area. It was determined, that the elasticity modulus (E) of scardeformed skin in the eyebrow area (Е=6.3±2.1 MPa) was higher than that of the lower eyelid area (Е=4.3±0.8 MPa) and the upper eyelid area (Е=3.6±0.5 MPa). The elasticity modulus of the skin of the inner surface of the shoulder (Е=4.0±0.5 MPa) is close to that of the scar-deformed skin of the lower eyelid, while the value of E for the posterior surface of the auricle is close to that of the upper eyelid scar-deformed skin (Е=2.5±0.4 MPa). The maximum rigidity was found to characterize the conjunctiva with burn-induced scars (Е=3.8±2.0 MPa), while the minimum rigidity was displayed by the conjunctiva of eyes with traumatic lesions without scars (Е=0.7±0.2 MPa). The elasticity modulus of lip mucosa (E=2.2±0.3 MPa), close to the respective parameter of scar-deformed conjunctiva (Е=1.9±0.4 MPa), shows that, from the biomechanical point of views, this tissue can be regarded as fully suitable for plastic surgery of the conjunctiva. Conclusions. Matching biomechanical parameters of periorbital area tissues and free transplants should be considered when choosing the transplants and developing the treatment plan of reconstructive plastic surgeries of traumatic scar deformities of eyelids and the conjunctiva