Measurement of implant deployment and related forces in kyphoplasty by percutaneous approach

BACKGROUND: The treatment of osteoporotic vertebral compression fractures using a transpedicular approach and cement injection has grown significantly over the last two decades. METHODS: The aim was to study the deployment of an implant dedicated to the vertebral augmentation by percutaneous approach (kyphoplasty). Its kinematics and the related forces have been investigated. A theoretical model of deployment has been proposed and the ancillary was instrumented with strain gauges and Hall effect sensors to measure kinematics and force in the deployment actuator (tensile rod). The methodology was first evaluated ex-vivo in a test-bench with boundary conditions monitored by a tensile machine. Then, a cadaver study was carried out in three lumbar and thoracic vertebral segments of normal and osteoporotic spines. FINDINGS: The relationships between ancillary internal forces, deployment, and cranio-caudal pushing force have been obtained. The test-bench experiment showed quasi-proportional relationship between force distribution and kinematics during the deployment. Ex-vivo cranio-caudal pushing forces were measured. Cadaver studies showed cranio-caudal pushing forces comprised between 100N and 200N. These forces were dependent upon the implant location in the vertebral body and bone stock. INTERPRETATION: The methodology was related to the analysis of load distribution and kinematics of a deployable implant for vertebral augmentation. The ancillary instrumentation contributed to the objective quantification of the surgical technique. The cadaver study in normal and osteoporotic spines exhibited the role of bone properties and implant location in implant deployment. This pilot study showed a methodology to improve the kyphoplasty surgery and patient comfort in clinical routine

Variété des contenus et niveau culturel au test de Rorschach

L'abondance et la variété des contenus de réponses au test de Rorschach sont classiquement interprétées comme l'indice des capacités intellectuelles d'un sujet. À partir d'une étude statistique sur les réponses au Rorschach comparées aux résultats d'un test d'intelligence, les auteurs montrent que la diversité des contenus est davantage en rapport avec le bagage culturel, la curiosité et le savoir. Les problèmes méthodologiques que pose l'interprétation des contenus au Rorschach sont discutés, en particulier par rapport aux implications culturelles de ces contenus.Bolzinger A., Hordern C., Dounovetz A. Variété des contenus et niveau culturel au test de Rorschach. In: Bulletin de la Société française du Rorschach et des méthodes projectives, n°24, 1970. pp. 101-107

Skin delivery of hydrophobic drugs using biocompatible and biodegradable carriers: Pickering emulsions and block copolymer nanoparticles. Correlation to drug localization within the skin layers as determined by confocal fluorescence microscopy

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14. Study of the percutaneous penetration of diagnosis pharmaceuticals in order to evaluate skin decontamination strategies

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Skin contamination by radiopharmaceuticals and decontamination strategies

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