Emotion Recognition Based on Facial Expressions Using Convolutional Neural Network (CNN)

Over the last few years, there has been an increasing number of studies about facial emotion recognition because of the importance and the impact that it has in the interaction of humans with computers. With the growing number of challenging datasets, the application of deep learning techniques have all become necessary. In this paper, we study the challenges of Emotion Recognition Datasets and we also try different parameters and architectures of the Conventional Neural Networks (CNNs) in order to detect the seven emotions in human faces, such as: anger, fear, disgust, contempt, happiness, sadness and surprise. We have chosen iCV MEFED (Multi-Emotion Facial Expression Dataset) as the main dataset for our study, which is relatively new, interesting and very challenging. © 2020 IEEE

NICE 2022 guidelines on the management of melanoma: Update and implications

Aims: In July 2022, NICE updated the guidelines on the management of melanoma by lowering the number of follow-up appointments and sentinel lymph node biopsy (SLNB) but increasing the number of scans. This study aims to evaluate the implications of executing the new guidelines in terms of cost-effectiveness and personnel. Methods: All patients newly diagnosed with melanoma in 2019 at a regional skin cancer specialist center were reviewed. Data were analyzed for their journey on an idealized pathway modeled over a 5-year follow-up period when adhering to both the previous and new guidelines. Differences in the management of melanoma were elucidated by comparing these changes. The cost was quantified on a perpatient basis and the financial implication on each department was considered. Results: One hundred and ten patients were diagnosed with melanoma in 2019, stages I-III. The changes ease the burden on plastic surgery and dermatology; however, increased pressure is faced by radiologists and histopathologists. An overall cost benefit of £141.85 perpatient was calculated, resulting in a decrease of 1.22 hospital visits on average and an increase in the time spent there (19.55 min). The additional expenses of implementing the new guidelines due to the added BRAF tests, CT, and ultrasound scans are outweighed by savings from the reduction in follow-up appointments and SLNB. Conclusion: The focus has shifted to less invasive procedures for lower melanoma stages and fewer follow-up appointments, at the expense of more genetic testing and imaging. This paper serves as a useful baseline for other centers to plan their service provision and resource allocation to adhere to the updated guidelines

Outcomes of primary rhegmatogenous retinal detachment repair with extensive scleral-depressed vitreous removal and dynamic examination.

There are multiple surgical approaches to the repair of rhegmatogenous retinal detachment (RRD). Here, we evaluated the outcomes of small-gauge pars plana vitrectomy (PPV), alone or in combination with scleral buckle (SB-PPV), for RRD repair using a standardized technique by 3 vitreoretinal surgeons: "extensive" removal of the vitreous with scleral depression and dynamic examination of the peripheral retina. One hundred eighty seven eyes of 180 consecutive patients treated for primary RRD by three vitreoretinal surgeons at a tertiary academic medical center from September 2015 to March 2018 were analyzed. Most RRDs occurred in males (134 [71.3%] eyes), affected the left eye (102 [54.3%]), and were phakic (119 [63.3%]). PPV alone was performed in 159 eyes (84.6%), with a combined SB-PPV used in the remaining 29 eyes (15.4%); focal endolaser was used in all (100%) cases. The single surgery anatomic success rate was 186 eyes (99.5%) at 3 months, and 187 (100%) at last follow up. Overall best-corrected visual acuity (BCVA) had significantly improved at 3 months ([Snellen 20/47] P<0.00005) and last follow up ([Snellen 20/31] P<0.00005), as compared to day of presentation ([Snellen 20/234]). Our findings suggest that "extensive" removal of the vitreous and dynamic peripheral examination with scleral depression may lead to high single surgery success in primary uncomplicated RRD repair

Xerofluvent Típico. Área de estudio: Fuentes de Andalucía. Localización: Río Corbones. Km 32 carretera Marchena-Écija

2 páginas. Este Perfil 1 se encuentra publicado en Citación, que corresponde a uno de los informes técnicos realizados en el Curso Internacional de Edafología y Biología Vegetal, patrocinado por la UNESCO-AECI y CSIC, que desde 1963 hasta 2009 se ha venido impartiendo en el CEBAC, actual IRNAS. En concreto, pertenece al XXVI Curso, 1989, cuyo original se encuentra en el IRNAS para su consulta, siendo su número de registro en ALEPH 208758. Este documento, además, se encuentra en la base de datos de Evenor-TEch (Spin-off del CSIC). http://www.evenor-tech.com/banco/seisnet/seisnet.htm., que incluye versiones en tres idiomas más.CEBAC-CSICPeer reviewe

IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

Abstract Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single cell sequencing datasets. This subtype of fibroblasts is linked to T cell and macrophage suppression and leads to increased cancer cell growth in 3D co-culture assays. Furthermore, both a fibroblast-specific IL1R1 knockout and IL-1 receptor antagonist Anakinra administration reduce tumor growth in vivo. This is accompanied by reduced intratumoral Th17 cell infiltration. Accordingly, CRC patients who present with IL1R1-expressing cancer-associated-fibroblasts (CAFs), also display elevated levels of immune exhaustion markers, as well as an increased Th17 score and an overall worse survival. Altogether, this study underlines the therapeutic value of targeting IL1R1-expressing CAFs in the context of CRC

Structure and quality assurance of fellowship training in general surgery: consensus recommendations from the Association of Surgeons in training

Background: Over three-quarters of surgical trainees intend to undertake clinical fellowships to improve competence, confidence and the development of super specialised skills. At present there is no standardised national regulation for fellowships in the UK, leading to variability. The Association of Surgeons in Training (ASiT), an organisation representing surgical trainees in the UK and Ireland, sought to provide recommendations on the structure and quality assurance of fellowships in General Surgery. Methods: A consensus session was held by ASiT at the Association of Surgeons of Great Britain and Ireland (ASGBI) 2017 Congress in Glasgow. A variety of perspectives on fellowships were presented by invited speakers, and thereafter a moderated discussion ensued in order to reach consensus. Live-polling using an electronic application facilitated consensus discussions. A writing group thereafter developed an initial consensus document which was then subject to electronic review by all authors and by ASiT council. Results: Thirty-four delegates attended the consensus session. Views of the delegates and online discussants were that fellowships should be optional and not mandatory. There was (n = 16) no preference expressed between UK and international fellowships by half the group, while half expressed a preference for international fellowships. Regarding UK fellowships, the majority (n = 24) said that national registration of such fellowships should be established and (n = 23) agreed that a defined curriculum was required. However, national selection into fellowship training was not supported (n = 20). Perceived advantages of UK fellowships included ease of relocating within the same country (which was considered more family-friendly and cost-effective), and familiarity with the NHS system. Delegates considered the advantages of international fellowships to include: access to high-volume centres; diversity of case-mix; and structured, regulated fellowship programmes. Conclusion: The consensus session found unanimous support for maintaining the option of both UK and international fellowships. While trainees support quality assurance of fellowships, they do not support a national selection process