Deep Impression: Audiovisual Deep Residual Networks for Multimodal Apparent Personality Trait Recognition

Here, we develop an audiovisual deep residual network for multimodal apparent personality trait recognition. The network is trained end-to-end for predicting the Big Five personality traits of people from their videos. That is, the network does not require any feature engineering or visual analysis such as face detection, face landmark alignment or facial expression recognition. Recently, the network won the third place in the ChaLearn First Impressions Challenge with a test accuracy of 0.9109

Proteomic analysis of differentially expressed proteins in vitamin C-treated AGS cells

Abstract Background Vitamin C (ascorbic acid) is an essential nutrient of most living tissues that readily acts as a strong reducing agent, which is abundant in fruits and vegetables. Although, it inhibits cell growth in many human cancer cells in vitro, treatment in cancer is still controversial. Hence, the purpose of this study was to investigate the molecular mechanism of the inhibitory effect of vitamin C on AGS cell growth, and protein profiles in AGS cells after exposure to vitamin C treatment, by using proteomic tools. Results Vitamin C showed a cytotoxic effect on AGS cells (IC50 300 μg/mL) and, 20 differentially expressed proteins (spot intensities which show ≥2 fold change and statistically significant, p&lt;0.05 between the control and vitamin-C treated group) were successfully identified by assisted laser desorption/ ionization-time of flight/mass spectrometry (MALDI-TOF/MS). Of the 20 proteins, six were up-regulated and fourteen were down-regulated. Specifically, 14-3-3σ, 14-3-3ϵ, 14-3-3δ, tropomyosin alpha-3 chain and tropomyosin alpha-4 chain were down-regulated and peroxiredoxin-4 and thioredoxin domain-containing proteins 5 were up-regulated. The identified proteins are mainly involved in cell mobility, antioxidant and detoxification, signal transduction and protein metabolism. Further, the expressions of 14-3-3 isoforms were verified with immuno-blotting analysis. Conclusions Our proteome results suggest that the apoptosis related proteins were involved in promoting and regulating cell death of AGS cells, and might be helpful to understand the molecular mechanism of vitamin C on AGS cell growth inhibition. </jats:sec

Regulation of Proinflammatory Mediators via NF-κB and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea Lonicera japonica THUNB

Lonicera japonica THUNB., which abundantly contains polyphenols, has been used as a traditional medicine for thousands of years in East Asian countries because of the anti-inflammation properties. This study aimed to investigate the anti-inflammatory mechanism of polyphenol components isolated from Korea L. japonica T. by nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinases (MAPKs) pathway. Polyphenols significantly decreased lipopolysaccharide- (LPS-) induced mRNA and protein expression of inducible nitric oxide synthase and cyclooxygenase-2, as well as mRNA expression of tumor necrosis factor-alpha, interleukin- (IL-) 1β, and IL-6. Moreover, polyphenols inhibited nuclear translocation of NF-κB p65, phosphorylation/degradation of the inhibitor of κB, and phosphorylation of p38 MAPK, whereas the extracellular signal-regulated kinase and Janus N-terminal kinase were not affected. These results indicate that polyphenol components isolated from Korea L. japonica T. should have anti-inflammatory effect on LPS-stimulated RAW 264.7 cells through the decrease of proinflammatory mediators expression by suppressing NF-κB and p38 MAPK activity

Flavonoids Isolated from Korea Citrus aurantium L. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells

Aim of the Study. Citrus species is used in traditional medicine as medicinal herb in several Asian countries including Korea. Flavonioids became known as various properties, such as anti-oxidants, anti-inflammation and anti-cancer, and so forth. The present study, the anti-cancer effect of flavonioids isolated from Citrus aurantium L. in human gastric cancer AGS cells has been investigated. Materials and Methods. The anti-proliferative activity was assayed using MTT assay. Cell cycle analysis was done using flow cytometry and apoptosis detection was done using by hoechst fluorescent staining and Annexin V-propidium iodide double staining. Western blot was used to detect the expression of protein related with cell cycle and apoptosis. Results. Flavonoids isolated from Citrus aurantium L. have the effect of anti proliferation on AGS cells with IC50 value of 99 μg/mL. Flavonoids inhibited cell cycle progression in the G2/M phase and decrease expression level of cyclin B1, cdc 2, cdc 25c. Flavonoids induced apoptosis through activate caspase and inactivate PARP. Conclusions. Flavonoids isolated from Citrus aurantium L. induced G2/M phase arrest through the modulation of cell cycle related proteins and apoptosis through activation caspase. These finding suggest flavonoids isolated from Citrus aurantium L. were useful agent for the chemoprevention of gastric cancer

Selective activation of Forearm muscles for improving Wrist Joint Stability

Abstract The wrist movements has important role in the daily life activities. Flexion, ExtensionandAbduction and Adduction are acceptable movements in the wrist. The Strength training of extensionis necessary for prevention of wrist sprains due to flexion movements because flexionforce is morethan extension Aim of this study was to improve the muscle strength by human resistive trainingand inspecting selective activation of forearm muscles in the above movements. 10 subjects wererecruited for performing maximum Isometric contraction at human resistive training and Flexorcarpiulnaris, Flexor carpi radialis,Extensor carpi radialislongusExtensor carpi ulnarisand abductorpollicislonguswereselected for investigation. Surface electromyography was used to get thecontraction level. Ourresult showed co activation of investigated muscles were less in synergistic thanagonist function (FCU:during Abduction 45%, ECU: during Abduction 37%, FCR:during adduction43%, ECRL: during adduction 29%, APL: during flexion 23%) (P&lt;0.0001).In the APL investigation, there was significant difference observed in the interaction effect (P=0.054, F(3, 9)=140.29,ηp2 =0.205). In the isometric training, biomechanical stability of radio carpal and midcarpal wasimproved due to strengthening of forearm muscles.</jats:p

A PFC Scheme for the Inverse Watkins Johnson Converter for Polarity Reversible Buck Boost DC Output Voltage

A power factor correction (PFC) scheme for the Inverse Watkins Johnson Converter (IWJC) drawing power from a single-phase AC source, delivering polarity reversible DC voltage output is presented in this paper. The IWJC is basically a DC-to-DC converter which can deliver a boosted positive output voltage or a negative output voltage with buck or boost feature. It is suitable for driving DC loads, typically, DC motors in forward or reverse direction. Unlike the conventional four quadrant DC chopper, the IWJC can boost the input voltage and deliver a voltage higher than the source voltage with duty cycle controlled polarity reversible feature. This paper presents the methodology of including a PFC strategy for the IWJC, when fed from a single-phase AC supply. The proposed methodology has established that the AC source side power factor is unity and that the source current is maintained sinusoidal. Simulations and experimental verifications validate the proposed idea. </jats:p