Sistem Kendali dan Pengawasan Wilayah Pintu Berbasis IoT

- In this study, an IoT-based door security system was proposed which facilitated homeowners to open and close doors and unlock doors through the internet. The system is also equipped with a real time video streaming feature so that the owner can save the environment around the door and ensure the person at the door before opening it. The Raspberry Pi is used as the main controller of the system that provides web pages for users and signatories to access Arduino Uno boards. Arduino Uno controls the servo to control the door. The camera used in this study is a Raspberry Camera with 5 MP resolution. From the results of the tests carried out, the results of the system that have been made can work well. Expected full service and response to changes in users on web pages is also quite fast. Streaming video runs smoothly at 30 fps with a resolution of 640x480.Keywords - Raspberry Pi, Streaming Video, Internet of Things, Door Contro

Prototype Topology SDN for Simple Network Campus

The use of communication networks is increasingly felt increasingly sophisticated. This can be seen with the use of innovative network infrastructure that provides connection services to users. Virtual service network can be a prototype of a software-based network logic in this case is a software-defined network. This software is open source-based or a lot of the paid version. Where this software serves as a bridge between networks that use routers or router software logic. Using a software-defined network on the router logic can be made very flexible and easy to integrate with a stable condition

Sistem Kekerabatan Pembentuk Pola Permukiman Dusun Krajan Kabupaten Lumajang

Penduduk Dusun Krajan tergolong sebagai masyarakat Tengger. Mereka memilikiaturan tersendiri mengenai tata letak hunian antar kerabat sebagai perwujudanadat istiadat dan budaya masyarakatnya. Selain kentalnya kebudayaan, dusuntersebut juga memiliki keindahan alam yang berdampak pada bertambahnyajumlah pendatang, yang diindikasikan akan membawa kebudayaan dan tradisiberbeda. Tujuan dari penelitian ini adalah untuk mengidentifikasi dan menganalisispengaruh sistem kekerabatan terhadap pola permukiman Dusun Krajan KabupatenLumajang. Metode identifikasi yang digunakan adalah deskriptif-kualitatif, denganmetode analisis family tree. Hasil menunjukan bahwa sistem kekerabatanmemberikan pengaruh terhadap transparasi antar bangunan hunian, orientasibangunan terhadap Gunung Bromo dan Pesanggrahan, hirarki dan tata letakhunian kakak tertua dalam kelompok bangunan pada permukiman Dusun Kraja

KYPO: A Tool for Collaborative Study of Cyberattacks in Safe Cloud Environment

This paper introduces the KYPO -- a cloud-based virtual environment faithfully simulating real networks and enabling users to study cyber attacks as well as to train users in isolated and controlled environment. Particularly, the paper focuses on the user environment and visualizations, providing views and interactions improving the understanding of processes emerged during experiments. Web user interface of the KYPO system supports several collaboration modes enabling the participants to experiment and replay different types of security related tasks

E-Business : at a Glance Indonesia Online Shop Agent

Condition of the seller and buyer are more numerous and scattered in Indonesia is quite difficult to communicate and conduct buying and selling process. Natural conditions that many Indonesian island is also one of its own difficulties. It has been strived for by the experts to make the mechanism of electronic business systems that can communicate between sellers and buyers. In the developed countries as an example of the American, British and French systems to work optimally, it means the system is very little human contact with the end-user. The system can be set to work as an intermediary that can automatically contact the seller or buyer. online shop agent in Indonesia for example, can be an effective solution to improve the economy indirectly to our government. And so is the main element of our own society

Designing IT Governance Approach Standard ISO 38500 for Indonesia Higher Education

The use of IT to support operational activities of an organization in both small and large scale, developed into a fundamental necessity in the face of the global era. University as an educational organization working to implement IT solutions to help its street operations and serve customers (students). ISO (the International Organization for Standardization) and IEC (the International Electrotechnical Commission) form the specialized system for worldwide standardization. National bodies that are members of ISO or IEC participate in the development of International Standards through technical committees established by the respective organization to deal with particular fields of technical activity. ISO and IEC technical committees collaborate in fields of mutual interest. Other International organizations, governmental and non-governmental, in liaison with ISO and IEC, also take part in the work. In the field of information technology, ISO and IEC have established a joint technical committee, ISO/IEC JTC 1

Long non-coding RNAs as local regulators of pancreatic islet transcription factor genes

The transcriptional programs of differentiated cells are tightly regulated by interactions between cell type-specific transcription factors and cis-regulatory elements. Long non-coding RNAs (lncRNAs) have emerged as additional regulators of gene transcription. Current evidence indicates that lncRNAs are a very heterogeneous group of molecules. For example, selected lncRNAs have been shown to regulate gene expression in cis or trans, although in most cases the precise underlying molecular mechanisms is unknown. Recent studies have uncovered a large number of lncRNAs that are selectively expressed in pancreatic islet cells, some of which were shown to regulate β cell transcriptional programs. A subset of such islet lncRNAs appears to control the expression of β cell-specific transcription factor (TF) genes by local cis-regulation. In this review, we discuss current knowledge of molecular mechanisms underlying cis-regulatory lncRNAs and discuss challenges involved in using genetic perturbations to define their function. We then discuss known examples of pancreatic islet lncRNAs that appear to exert cis-regulation of TF genes. We propose that cis-regulatory lncRNAs could represent a molecular target for modulation of diabetes-relevant genes

Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups

Studies indicate that stathmin expression associates with PI3K activation in breast cancer, suggesting stathmin as a marker for targetable patient subgroups. Here we assessed stathmin in relation to tumour proliferation, vascular and immune responses, BRCA1 germline status, basal-like differentiation, clinico-pathologic features, and survival. Immunohistochemical staining was performed on breast cancers from two series (cohort 1, n = 187; cohort 2, n = 198), and mass spectrometry data from 24 cases and 12 breast cancer cell lines was examined for proteomic profiles. Open databases were also explored (TCGA, METABRIC, Oslo2 Landscape cohort, Cancer Cell Line Encyclopedia). High stathmin expression associated with tumour proliferation, p53 status, basal-like differentiation, BRCA1 genotype, and high-grade histology. These patterns were confirmed using mRNA data. Stathmin mRNA further associated with tumour angiogenesis, immune responses and reduced survival. By logistic regression, stathmin protein independently predicted a BRCA1 genotype (OR 10.0, p = 0.015) among ER negative tumours. Cell line analysis (Connectivity Map) implied PI3K inhibition in tumours with high stathmin. Altogether, our findings indicate that stathmin might be involved in the regulation of tumour angiogenesis and immune responses in breast cancer, in addition to tumour proliferation. Cell data point to potential effects of PI3K inhibition in tumours with high stathmin expression.publishedVersio

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

RNF43/ZNRF3 negatively regulate WNT signalling. Both genes are mutated in several types of cancers, however, their contribution to liver disease is unknown. Here we describe that hepatocyte-specific loss of Rnf43/Znrf3 results in steatohepatitis and in increase in unsaturated lipids, in the absence of dietary fat supplementation. Upon injury, Rnf43/Znrf3 deletion results in defective hepatocyte regeneration and liver cancer, caused by an imbalance between differentiation/proliferation. Using hepatocyte-, hepatoblast- and ductal cell-derived organoids we demonstrate that the differentiation defects and lipid alterations are, in part, cell-autonomous. Interestingly, ZNRF3 mutant liver cancer patients present poorer prognosis, altered hepatic lipid metabolism and steatohepatitis/NASH signatures. Our results imply that RNF43/ZNRF3 predispose to liver cancer by controlling the proliferative/differentiation and lipid metabolic state of hepatocytes. Both mechanisms combined facilitate the progression towards malignancy. Our findings might aid on the management of those RNF43/ZNRF3 mutated individuals at risk of developing fatty liver and/or liver cancer