A non extensive approach for DNA breaking by ionizing radiation

Tsallis entropy and a maximum entropy principle allows to reproduce experimental data of DNA double strand breaking by electron and neutron radiation. Analytic results for the probability of finding a DNA segment of length l are obtained reproducing quite well the fragment distribution function experimentally obtained

Design and development of a CT imaging system for small animals

[Abstract] AMI International Conference 2003, September 21 - 27, Madrid, Spain: "High Resolution Molecular Imaging: from Basic Science to Clinical Applications"Positron emission tomography (PET) studies of small animals benefits from the registration of the functional information they provide with accurate anatomic images provided by dedicated computed tomography (CT) scanners. These scanners have to achieve the micrometric resolution requirements needed to locate structures in small laboratory animals like mice and rats. This work reports on a prototype based on a solid state semiconductor X-ray sensor and a microfocus Xray source.Publicad

Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy

The nanomechanical properties of living cells, such as their surface elastic response and adhesion, have important roles in cellular processes such as morphogenesis(1), mechano-transduction(2), focal adhesion(3), motility(4,5), metastasis(6) and drug delivery(7-10). Techniques based on quasi-static atomic force microscopy techniques(11-17) can map these properties, but they lack the spatial and temporal resolution that is needed to observe many of the relevant details. Here, we present a dynamic atomic force microscopy(18-28) method to map quantitatively the nanomechanical properties of live cells with a throughput (measured in pixels/minute) that is similar to 10-1,000 times higher than that achieved with quasi- static atomic force microscopy techniques. The local properties of a cell are derived from the 0th, 1st and 2nd harmonic components of the Fourier spectrum of the AFM cantilevers interacting with the cell surface. Local stiffness, stiffness gradient and the viscoelastic dissipation of live Escherichia coli bacteria, rat fibroblasts and human red blood cells were all mapped in buffer solutions. Our method is compatible with commercial atomic force microscopes and could be used to analyse mechanical changes in tumours, cells and biofilm formation with sub-10 nm detail

Validación del monitor de medición de la grasa corporal por impedancia bioeléctrica OMRON BF 300

ObjetivosValorar la precisión del monitor de grasa corporal por impedancia bioeléctrica OMRON BF 300 y validar su medición del porcentaje de grasa corporal (%GC) frente a la ecuación de Siri. Diseño. Estudio descriptivo, transversal.EmplazamientoAtención primaria. Centros de Salud Coronel de Palma y San Fernando, Móstoles.ParticipantesEn la valoración de la precisión del monitor participaron 88 personas y 91 en la validación.Mediciones y resultados principalesLas determinaciones de %GC se realizaron por triplicado, anotándose la media. La precisión se evaluó mediante el coeficiente de correlación intraclase (CCI) y el coeficiente de variación (CV). La validez, mediante el error técnico, el CCI y el método de Bland-Altman. En la ecuación de Siri la densidad corporal se calculó con la ecuación de Durnin-Womersley. Precisión: el CCI fue de 0,999 y el CV de 0,4 ± 0,03. Validación: la diferencia de %GC monitor (26,6 ± 9,1%) – ecuación de Siri (27,8 ± 8,2%) fue de –1,27% (p < 0,01; IC del 95%, –1,97 a –0,57), el error técnico del monitor del 2,2% y el CCI de 0,956 (IC del 95%, 0,9335–0,9710), situándose un 80,2% de las diferencias monitor – ecuación por debajo del 5%, con un intervalo de concordancia por el método de Bland-Altman de +5,45 a –7,99%.ConclusionesEl monitor OMRON BF 300 satisface los criterios de precisión (CCI > 0,95 y CV bajo) y validación (error técnico excelente, CCI > 0,75 y diferencias clínicamente aceptables) y supone una alternativa válida a los pliegues cutáneos en la valoración nutricional del paciente.ObjectivesTo assess the accuracy of the OMRON BF 300 body fat monitor using bioelectric impedance and to validate its measurement of body fat percentage (BF%) against the Siri equation.DesignCross-sectional descriptive study.SettingPrimary care. Coronel de Palma and San Fernando Health Centres, Móstoles.Participants88 people took part in the assessment of the accuracy of the monitor, and 91 in the validation.Measurements and main resultsThe BF% were recorded in triplicate, with the mean being the figure noted. Precision was evaluated through the intra-class correlation coefficient (ICC) and the coefficient of variation (CV); validity, through technical error, the ICC and the Bland-Altman method. In the Siri equation, body density was calculated through the Durnin-Womersley equation. Precision: ICC was 0.999 and CV 0.4 ± 0.03. Validation: the difference between the BF% monitor (26.6 ± 9.1%) and the Siri equation (27.8 ± 8.2%) was –1.27% (p < 0.01; 95% CI –1.97 to –0.57); the technical error of the monitor was 2.2% and of the ICC 0.956 (95% CI, 0.9335–0.9710). Thus, 80.2% of the monitor-equation differences were below 5%, with a concordance interval under the Bland-Altman method of +5.45 to –7.99%.ConclusionsThe OMRON BF 300 monitor satisfies the precision criteria (ICC > 0.95 and low CV) and validation (excellent technical error, ICC > 0.75 and clinically acceptable differences) and is a valid alternative to cutaneous folds as a method of assessing nutrition of the patient

A Bethe lattice representation for sandpiles

Avalanches in sandpiles are represented throughout a process of percolation in a Bethe lattice with a feedback mechanism. The results indicate that the frequency spectrum and probability distribution of avalanches resemble more to experimental results than other models using cellular automata simulations. Apparent discrepancies between experiments are reconciled. Critical behavior is here expressed troughout the critical properties of percolation phenomena.Comment: 5 pages, 4 figures, submitted for publicatio

MAGIC detection of very high energy gamma-ray emission from the low-luminosity blazar 1ES 1741+196

We present the first detection of the nearby (z=0.084) low-luminosity BL Lac object 1ES 1741+196 in the very high energy (VHE: E>100 GeV) band. This object lies in a triplet of interacting galaxies. Early predictions had suggested 1ES 1741+196 to be, along with several other high-frequency BL Lac sources, within the reach of MAGIC detectability. Its detection by MAGIC, later confirmed by VERITAS, helps to expand the small population of known TeV BL Lacs. The source was observed with the MAGIC telescopes between 2010 April and 2011 May, collecting 46 h of good quality data. These observations led to the detection of the source at 6.0 σ confidence level, with a steady flux F(> 100 GeV) = (6.4 ± 1.7_(stat) ± 2.6_(syst)) • 10^(−12) ph cm^(−2) s^( −1) and a differential spectral photon index Γ = 2.4 ± 0.2_(stat) ± 0.2_(syst) in the range of ∼80 GeV - 3 TeV. To study the broad-band spectral energy distribution (SED) simultaneous with MAGIC observations, we use KVA, Swift/UVOT and XRT, and Fermi/LAT data. One-zone synchrotron-self-Compton (SSC) modeling of the SED of 1ES 1741+196 suggests values for the SSC parameters that are quite common among known TeV BL Lacs except for a relatively low Doppler factor and slope of electron energy distribution. A thermal feature seen in the SED is well matched by a giant elliptical’s template. This appears to be the signature of thermal emission from the host galaxy, which is clearly resolved in optical observations

Very-high-energy gamma-ray observations of the Type Ia Supernova SN 2014J with the MAGIC telescopes

Context. In this work we present data from observations with the MAGIC telescopes of SN 2014J detected in January 21 2014, the closest Type Ia supernova since Imaging Air Cherenkov Telescopes started to operate. Aims. We probe the possibility of very-high-energy (VHE; E ≥ 100 GeV) gamma rays produced in the early stages of Type Ia supernova explosions. Methods. We performed follow-up observations after this supernova explosion for 5 days, between January 27 and February 2 in 2014. We search for gamma-ray signal in the energy range between 100 GeV and several TeV from the location of SN 2014J using data from a total of ∼ 5.5 hours of observations. Prospects for observing gamma-rays of hadronic origin from SN 2014J in the near future are also being addressed. Results. No significant excess was detected from the direction of SN 2014J. Upper limits at 95% confidence level on the integral flux, assuming a power-law spectrum, dF/dE ∝ E −Γ , with a spectral index of Γ = 2.6, for energies higher than 300 GeV and 700 GeV, are established at 1.3 × 10−12 and 4.1 × 10−13 photons cm−2 s −1 , respectively. Conclusions. For the first time, upper limits on the VHE emission of a Type Ia supernova are established. The energy fraction isotropically emitted into TeV gamma rays during the first ∼ 10 days after the supernova explosion for energies greater than 300 GeV is limited to 10−6 of the total available energy budget (∼ 1051 erg). Within the assumed theoretical scenario, the MAGIC upper limits on the VHE emission suggest that SN 2014J will not be detectable in the future by any current or planned generation of Imaging Atmospheric Cherenkov Telescopes