X-raying the coronae of HD~155555

We present an analysis of the high-resolution Chandra observation of the multiple system, HD 155555 (an RS CVn type binary system, HD 155555 AB, and its spatially resolved low-mass companion HD 155555 C). This is an intriguing system which shows properties of both an active pre-main sequence star and a synchronised (main sequence) binary. We obtain the emission measure distribution, temperature structures, plasma densities, and abundances of this system and compare them with the coronal properties of other young/active stars. HD 155555 AB and HD 155555 C produce copious X-ray emission with log Lx of 30.54 and 29.30, respectively, in the 0.3-6.0 keV energy band. The light curves of individual stars show variability on timescales of few minutes to hours. We analyse the dispersed spectra and reconstruct the emission measure distribution using spectral line analysis. The resulting elemental abundances exhibit inverse first ionisation potential effect in both cases. An analysis of He-like triplets yields a range of coronal electron densities ~10^10-10^13 cm-3. Since HD 155555 AB is classified both as an RS CVn and a PMS star, we compare our results with those of other slightly older active main-sequence stars and T Tauri stars, which indicates that the coronal properties of HD 155555 AB closely resemble that of an older RS CVn binary rather than a younger PMS star. Our results also suggests that the properties of HD 155555 C is very similar to those of other active M dwarfs.Comment: 17 pages, 23 figues, Accepted in Ap

MOSQUITO LARVICIDAL EFFICACY OF THE ACETONE LEAF EXTRACT OF SOLANUM TRILOBATUM AGAINST CULEX QUINQUEFASCIATUS AND AEDES AEGYPTI

Objective: The main objective of our study is to control the vector-borne disease. It is one among the major disease burden in developing countries. There are lots of researches carried out using the various plant extracts against larvicidal activities of the Culex quinquefasciatus and Aedes aegypti. The present investigation was aimed to investigate the phytochemical analysis and mosquito larvicidal activities of Solanum trilobatum in acetone extract against the second instar larvae of C. quinquefasciatus and A. aegypti. Methods: The leaf extract of S. trilobatum was subjected to phytochemical analysis and Gas Chromatography–Mass Spectrometry analysis. The mortality rates of the second instar larvae were recorded after 24, 48, 72, and 96 h of exposure. The lethal concentration (LC)50 and LC90 were determined followed by probit analysis.Results: The LC50 values for C. quinquefasciatus were found to be 265.69 ppm, 227.59 ppm, 212.42 ppm, and 189.47 ppm at various time intervals, and the LC90 values were 558.27 ppm, 504.92 ppm, 479.09 ppm, and 444.28 ppm. Similarly, LC50 values for A. aegypti were noticed at 301.09 ppm, 256.01 ppm, 209.75 ppm, and 167.44 ppm and the LC90 values were 582.34 ppm, 477.52 ppm, 419.40 ppm, and 371.84 ppm for the time interval of 24 h, 48 h, 72 h, and 96 h.Conclusion: The result of the current work revealed that the leaf extract of the S. trilobatum has the potential to be acted as an alternative for the controlling of the mosquitoes

InterferenceAnalyzer: Tools for the analysis and simulation of multi-locus genetic data

BACKGROUND: Good statistical models for analyzing and simulating multilocus recombination data exist but are not accessible to many biologists because their use requires reasonably sophisticated mathematical and computational implementation. While some labs have direct access to statisticians or programmers competent to carry out such analyses, many labs do not. We have created a platform independent application with an easy-to-use graphical user interface that will carry out such analyses including the simulations needed to bootstrap confidence intervals for the parameters of interest. This software should make multi-locus techniques accessible to labs that previously relied on less powerful and potentially statistically confounded single interval or double interval techniques. RESULTS: We introduce InterferenceAnalyzer, an implementation with a user-friendly graphical interface incorporating previously developed algorithms for the analysis and simulation of multilocus recombination data. We demonstrate the use and features of the program with an example of multilocus tetrad data from the mustard plant, Arabidopsis thaliana, and the yeast, Saccharomyces cerevisiae. CONCLUSION: InterferenceAnalyzer provides easy access to the powerful and appropriate statistical tools for the multi-locus analysis of genetic data

Adjunct hexagonal array token Petri nets and hexagonal picture languages

Adjunct Hexagonal Array Token Petri Net Structures (AHPN) are re- cently introduced hexagonal picture generating devices which extended the Hexag- onal Array Token Petri Net Structures . In this paper we consider AHPN model along with a control feature called inhibitor arcs and compare it with some ex- pressive hexagonal picture generating and recognizing models with respect to the generating power

Single crystal structure, Computational study (DFT) and Hirshfeld surface analysis of 4-chloro-1H-pyrazole

       The 4-chloro-1H-Pyrazole, C3H3ClN2 has grown in orthorhombic crystal system. The crystal packing stabilized using intermolecular N-H…H hydrogen bonding. The crystal structure of 4-chloro-1H-Pyrazole theoretically analyzed using Density Functional Theory (DFT) with B3LYP++G(d,p) basic set. The highest occupied molecular orbital, the lowest unoccupied molecular orbital, molecular electrostatic potential,and natural bond orbital of the optimized structure have been evaluated. Theoretical UV–Vis spectrum of the compound has been carried out for the better understanding of electronic absorption spectra with the help of the time-dependent density functional theory at room temperature.Hirshfeld surface analysis and two-dimensional fingerprint plots were used to investigate and quantify the intermolecular interactions in the crystal.

Extraction, Characterization, and Molecular Weight Determination of Senna tora

The objective of the present work was extraction of polysaccharide from Senna tora L. seed and its characterization as a pharmaceutical excipient. Polysaccharide extraction was based on mechanical separation of the endosperm of seeds of Senna tora, water dissolution, centrifugation, and precipitation with acetone. Standard procedures were used to study the viscosity, micromeritic properties, and microbial bioburden. Accelerated stability study was carried out on isolated polysaccharide for six months at 40°C/75 RH as per ICH guidelines. The gum obtained from S. tora seeds was an amorphous free flowing odourless powder with dull brown colour (yield = 35% w/w). The bulk density, tapped density, and angle of repose data reveal that S. tora gum possesses good flow property. The intrinsic viscosity obtained was 1.568 dL/g. The average molecular weight of purified S. tora gum was found to be 198 kDa by intrinsic viscosity method. The results indicated that viscosity of gum solution increases with increase in temperature. FTIR study revealed the absence of degradation or decomposition of polysaccharide at accelerated stability conditions for six months. It has been concluded that extracted polysaccharide can be used as pharmaceutical excipient in terms of flow behavior, microbial properties, and stability

BLOCKCHAIN TECHNOLOGY FOR DETECTING FRAUD IN PHARMACEUTICAL SUPPLY CHAIN MANAGEMENT

Aim: This paper mainly focused on proposing a new pharmaceutical supply chain management system based on block chain technology.    Results: A seven steps pharmaceutical supply chain management is designed based on blockchain technology. The patients are encouraged to access the technology for finding genuinity of the medicine and to reduce fraud detection.    Conclusion: Blockchain is used to make the system more efficient and effective and designing such genuine system with all necessary parameters can boost patient confidence during medication.  Keywords: Pharmaceutical supply chain management, blockchain technology, patients, medicin