Profiling of adipokine secretion by adipose tissue in transgenic mice with homotopic overexpression of adiponectin

BACKGROUND AND AIMS: We have generated a transgenic (Tg) mouse model allowing persistent and moderate overexpression of native adiponectin (ApN) targeted to white adipose tissue [the transgene being placed under control of aP2 (fatty-acid binding protein) promoter]. Adiposity was reduced in aging mice fed a high-sucrose diet and this anti-obesity effect favored enhanced insulin sensitivity and improved lipid profile. APN appears to be a potent regulator of other adipokines. We took advantage of this unique in vivo model to study the influence of APN on adipokine secretion profiling. In order to investigate the early and specific effects of APN, mice were studied before any significant decrease of fat mass or glycemia and circulating lipids occurred […