La ganadería puede ser un aliado en la lucha contra el cambio climático, la desertificación y la pérdida de la biodiversidad si se implementan prácticas sostenibles

Expertos participaron en 5 webinarios para compartir experiencias que permitan comprender el aporte de la ganadería a las actividades de mitigación del cambio climático y la conservación de la biodiversidad de los ecosistemas. Se reconoció la importancia de la ganadería en la bioeconomía circular, la protección de pastizales como método de conservación de la biodiversidad y la sostenibilidad agrícola y, la adopción de estrategias de manejo adecuadas para promover el desarrollo del carbono redicular susbterráneo. Por otro lado, se resaltaron las oportunidades económicas y tendencias del mercado financiero, la importancia de las estrategias que integren a distintos actores del sistema y la necesidad de considerar la huella medioambiental para abordar la problemática y disminuir el impacto en los ecosistema

pRb2/p130 localized to the Cytoplasm in Diffuse Gastric Cancer

pRb2/p130 is a key tumor suppressor, whose oncosuppressive activity has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors. Indeed, pRb2/p130 has been found altered in various cancer types in which it functions as a valuable prognostic marker. Here, we analyzed pRb2/p130 expression in gastric cancer tissue samples of diffuse histotype, in comparison with their normal counterparts. We found a cytoplasmic localization of pRb2/p130 in cancer tissue samples, whereas, in normal counterparts, we observed the expected nuclear localization. pRb2/p130 cytoplasmic delocalization can lead to cell cycle deregulation, but considering the emerging involvement of pRb2/p130 in other key cellular processes, it could contribute to gastric tumorigenesis also through other mechanisms. Our data support the necessity of further investigations to verify the possibility of using pRb2/p130 as a biomarker or potential therapeutic target for diffuse gastric cancer

Consejo Técnico Consultivo. Informe de la Quinta Reunión

306 páginas. Ils.Este informe de la quinta reunión contiene: -Conclusiones, proposiciones en orden de prioridad -Conclusiones, resoluciones -Delegados permanentes y observadores -Participantes de la quinta reunión -Autoridades y funcionarios de la quinta reunión -Comité

QSAR Models for Human Carcinogenicity: An Assessment Based on Oral and Inhalation Slope Factors

Carcinogenicity is a crucial endpoint for the safety assessment of chemicals and products. During the last few decades, the development of quantitative structure-activity relationship ((Q)SAR) models has gained importance for regulatory use, in combination with in vitro testing or expert-based reasoning. Several classification models can now predict both human and rat carcinogenicity, but there are few models to quantitatively assess carcinogenicity in humans. To our knowledge, slope factor (SF), a parameter describing carcinogenicity potential used especially for human risk assessment of contaminated sites, has never been modeled for both inhalation and oral exposures. In this study, we developed classification and regression models for inhalation and oral SFs using data from the Risk Assessment Information System (RAIS) and different machine learning approaches. The models performed well in classification, with accuracies for the external set of 0.76 and 0.74 for oral and inhalation exposure, respectively, and r2 values of 0.57 and 0.65 in the regression models for oral and inhalation SFs in external validation. These models might therefore support regulators in (de)prioritizing substances for regulatory action and in weighing evidence in the context of chemical safety assessments. Moreover, these models are implemented on the VEGA platform and are now freely downloadable online

QSAR Models for Human Carcinogenicity: An Assessment Based on Oral and Inhalation Slope Factors

Carcinogenicity is a crucial endpoint for the safety assessment of chemicals and products. During the last few decades, the development of quantitative structure-activity relationship ((Q)SAR) models has gained importance for regulatory use, in combination with in vitro testing or expert-based reasoning. Several classification models can now predict both human and rat carcinogenicity, but there are few models to quantitatively assess carcinogenicity in humans. To our knowledge, slope factor (SF), a parameter describing carcinogenicity potential used especially for human risk assessment of contaminated sites, has never been modeled for both inhalation and oral exposures. In this study, we developed classification and regression models for inhalation and oral SFs using data from the Risk Assessment Information System (RAIS) and different machine learning approaches. The models performed well in classification, with accuracies for the external set of 0.76 and 0.74 for oral and inhalation exposure, respectively, and r2 values of 0.57 and 0.65 in the regression models for oral and inhalation SFs in external validation. These models might therefore support regulators in (de)prioritizing substances for regulatory action and in weighing evidence in the context of chemical safety assessments. Moreover, these models are implemented on the VEGA platform and are now freely downloadable online

Memoria Encuentro de Capacitación e Integración del Personal Profesional de la Zona Norte

216 páginasEste documento contiene información sobre el Encuentro de Capacitación e Integración del Personal Profesional de la Zona Norte, en el cual se presenta información el Proyecto PIADIC y sus logros hasta marzo 1979 y los productos que se esperan hasta 1982, explicar las proyecciones del Proyecto

Programa Cooperativo Centroamericano para el Mejoramiento de Cultivos Alimenticios: Frijol

192 páginas. Series Publicación miscelánea 67.Este documento presenta: -La agricultura y su proyección futura en Centroamérica -Algunas sugerencias para mejorar los procedimientos experimentales -Informe sobre las actividades regionales para la integración de la investigación agropecuaria -El servicio de extensión agropecuaria de Honduras en la producción de granos básicos. -Producción de semilla - Comportamiento de líneas y variedades experimentales de frijol en Honduras -resultados de tres experimentos con variedades de frijol en Honduras- 1966 -Trabajos realizados por el programa de frijol en Guatemala 1967 -Enfermedades virosas del frijol en Costa Rica -Informes de fertilización de la sección de suelos en El Salvador -Ensayos de fertilizantes en frijol en Nicaragu