De kracht van de coöperatie:nieuwe organisatievormen in zorg en welzijn als gevolg van hervormingen in de zorg

Het is al vaker gezegd: een crisis kan een bron zijn van innovatie. Hoewel demografische ontwikkelingen al decennia lang wijzen in de richting van een onbetaalbaar zorgstelsel, bood de financiële crisis de argumenten om daadwerkelijk hervormingen door te voeren. De ideologische onderbouwing werd geformuleerd als het streven naar een participatiesamenleving waarin iedereen mee doet en waarin zorg voor elkaar een wezenlijke waarde is

Insulin-like growth factor-II in the cycle of life

The insulin-like growth factors (IGF-I and IGF-II) play important roles in growth and development. They are structurally homologous to proinsulin and can interact with the type I and type II IGF receptors and, to a lesser extent, the insulin receptor. IGF have potent hypoglycemic activity, which is modulated by the presence of specific IGF-binding proteins, six of which (IGFBP-1 to IGFBP-6) have been cloned to date. Postnatally, IGF-stimulated growth is merely regulated by pituitary-derived growth hormone (GH). However, prenatal growth regulation by IGF is GH-independent. IGF and IGFBP are produced by many tissues and circulate in plasma, suggesting that they act both by endocrine and autocrine/paracrine mechanisms. In spite of the vast literature about IGF, their physiological implications in prenatal and postnatal growth regulation are insufficiently known. This is especially true for IGF-II. Therefore, this article will dance round a few selected aspects relevant to the biological effects of IGF-II in vivo.Biomedical Reviews 1996; 5: 65-71

The role of the IGF axis in IGFBP-1 and IGF-I induced renal enlargement in Snell dwarf mice

Insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) is generally believed to inhibit IGF action in the circulation. In contrast, IGFBP-1 has been reported to interact with cell surfaces and enhance IGF-I action locally in some tissues. Renal IGFBP-1 levels are found elevated in various conditions characterized by renal growth (e.g. diabetes mellitus, hypokalemia). To test whether IGFBP-1 is a renotropic factor, IGFBP-1 was administered alone or in combination with IGF-I to Snell dwarf mice, an in vivo model without compensatory feedback effects on growth hormone (GH) secretion. In three control groups of Snell dwarf mice, placebo, GH or IGF-I was administered. Compared with placebo, kidney weight increased in all treated groups, however, with different effects on kidney morphology. Administration of IGF-I, alone or in combination with IGFBP-1, tended to increase glomerular volume, while no changes were seen in the other groups. Administration of IGFBP-1 or IGFBP-1+IGF-I both caused dilatation of the thin limbs of Henle's loop, while GH or IGF-I administration had no visible effect. Furthermore, IGF-I administration resulted in an increased mean number of nuclei per cortical area and renal weight, whereas GH, IGF-I+IGFBP-1 or IGFBP-1 caused a decreased renal nuclei number. In situ hybridization and immunohistochemistry showed specific changes of the renal IGF system expression patterns in the different groups. Particularly, IGFBP-1 administration resulted in extensive changes in the mRNA expression of the renal IGF system, whereas the other administration regimen resulted in less prominent modifications. In contrast, administration of IGFBP-1 and IGFBP-1+IGF-I resulted in identical changes in the protein expression of the renal IGF system. Our results indicate that IGFBP-1, alone or in combination with IGF-I, demonstrated effects on the renal tubular system that differ from the effects of IGF-I

The Right Place at the Right Time: Creative Spaces in Libraries

Purpose This essay explores the recent trend in libraries: that of the establishment of spaces specifically set aside for creative work. The rise of these dedicated creative spaces is owed to a confluence of factors that happen to be finding their expression together in recent years. This essay examines the history of these spaces and explores the factors that gave rise to them and will fuel them moving forward. Design/Methodology/Approach A viewpoint piece, this essay combines historical research and historical/comparative analyses to examine the ways by which libraries have supported creative work in the past and how they may continue to do so into the 21st century. Findings The key threads brought together include a societal recognition of the value of creativity and related skills and attributes; the philosophies, values, and missions of libraries in both their longstanding forms and in recent evolutions; the rise of participatory culture as a result of inexpensive technologies; improved means to build community and share results of efforts; and library experience and historical practice in matters related to creativity. The chapter concludes with advice for those interested in the establishment of such spaces, grounding those reflections in the author’s experiences in developing a new creative space at Virginia Commonwealth University. Originality/value While a number of pieces have been written that discuss the practicalities of developing certain kinds of creative spaces, very little has been written that situates these spaces in larger social and library professional contexts; this essay begins to fill that gap

Talin: Adherens Junction Protein Is Localized at the Epidermal-Dermal Interface in Skin

The interaction between cells of the epidermis and the basal lamina is important for the integrity of the skin. Several hereditary and acquired diseases show changes at the dermal-epidermal interface due to loss of adhesion between basal cells and the basement membrane. The structures mediating this interaction are hemidesmosomes, which have been extensively characterized by biochemical, molecular biologic, and morphologic techniques. Recently, however, a group of adhesion molecules that are distinct from hemidesmosomes and that mediate cell-matrix interactions was described in cultured fibroblasts, keratinocytes, and skin. These adhesion molecules, β1 integrins, have been shown to be present in the focal adhesion, a cell-matrix contact associated with microfilaments rather than intermediate filaments characteristic of hemidesmosomes. In cultured cells, integrins of the β1 family have been shown to be linked by a protein complex to actin filaments. In this study we describe the localization of talin, the binding protein for β1 integrins, and vinculin at the dermal-epidermal interface in skin with immunofluorescence and immunoblotting techniques. These data suggest the presence of a link between the cytoplasmic actin filament system in basal keratinocytes and the extracellular matrix

Ervaringen van ondernemers met medewerkers met een beperking:Ondernemen met een sociaal gezicht

Uit onderzoek van de Hanzehogeschool Groningen blijkt dat ondernemers bij de uitvoering van de Wet Banenafspraak en quotum arbeidsbeperkten vragen om betrouwbaar partnerschap en het voor ogen houden van het gemeenschappelijke doel: werkplekken bieden

Opleiden voor de krapte op de arbeidsmarkt

Door de krapte op de arbeidsmarkt leiden steeds meer ondernemers zelf (potentiële) werknemers op ten behoeve van het vervullen van vacatures. In dit artikel enkele voorbeelden van ondernemers die dit hebben opgepakt