Low-level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 2: proposed applications and treatment protocols

Purpose: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT), more recently termed photobiomodulation (PBM) for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved and dosimetric parameters may lead to the management of a broader range of complications associated with HNC treatment. This could enhance patient adherence to cancer therapy, and improve quality of life and treatment outcomes. The mechanisms of action, dosimetric, and safety considerations for PBM have been reviewed in part 1. Part 2 discusses the head and neck treatment side effects for which PBM may prove to be effective. In addition, PBM parameters for each of these complications are suggested and future research directions are discussed. Methods: Narrative review and presentation of PBM parameters are based on current evidence and expert opinion. Results: PBM may have potential applications in the management of a broad range of side effects of (chemo)radiation therapy (CRT) in patients being treated for HNC. For OM management, optimal PBM parameters identified were as follows: wavelength, typically between 633 and 685 nm or 780–830 nm; energy density, laser or light-emitting diode (LED) output between 10 and 150 mW; dose, 2–3 J (J/cm2), and no more than 6 J/cm2 on the tissue surface treated; treatment schedule, two to three times a week up to daily; emission type, pulsed (<100 Hz); and route of delivery, intraorally and/or transcutaneously. To facilitate further studies, we propose potentially effective PBM parameters for prophylactic and therapeutic use in supportive care for dermatitis, dysphagia, dry mouth, dysgeusia, trismus, necrosis, lymphedema, and voice/speech alterations. Conclusion: PBM may have a role in supportive care for a broad range of complications associated with the treatment of HNC with CRT. The suggested PBM irradiation and dosimetric parameters, which are potentially effective for these complications, are intended to provide guidance for well-designed future studies. It is imperative that such studies include elucidating the effects of PBM on oncology treatment outcomes.National Institutes of Health (U.S.) (NIH grant R01AI050875

Twenty-Second Annual Commencement Exercises

Order of Exercises Processional: Herbert C. Dobrinsky, Vice President for University Affairs, Yeshiva University; Herald Michael Eric Herz, Senior Associate Dean, Benjamin N. Cardozo School of Law; Chief Marshal Presiding: Normal Lamm, President, Yeshiva University National Anthem: Cantor Ira W. Heller, The Jewish Center, New York City Invocation: Yakov Deckelbaum, Benjamin N. Cardozo School of Law, Class of 2000 Tribute to Dean Verkuil: Dr. Lamm Welcome: Paul R. Verkuil, Dean, Benjamin N. Cardozo School of Law Commencement Address: Charles E. Schumer, United States Senator, State of New York Remarks: Earle I. Mack, Chairman, Board of Directors, Benjamin N. Cardozo School of Law Alumni Greetings: Noel L.C. Williams, Class of 1987 Student Remarks: James Howell Sullivan, Jr., Class of 2000 Awards and Honors: Dean Herz Conferring of Master of Laws Degrees Conferring of Juris Doctor Degrees: Dr. Lamm Dean Verkuil Hatikvah: Cantor Heller Recessionalhttps://larc.cardozo.yu.edu/pre-19-programs/1021/thumbnail.jp

As manifestações e complicações orais da terapia do cancro

Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas MonizOs tratamentos atuais do cancro permitem geralmente adiar ou estabilizar a doença, mas raramente curou completamente. Em consequência os pacientes têm de viver com a doença, os seus tratamentos altamente invasivos e as manifestações induzidas, e reduzem significativamente a qualidade de vida. Em primeiro lugar, este trabalho tem com objetivo estudar funcionamento dos diferentes tipos de tratamento usados contra o cancro, tais como a quimioterapia, a radioterapia, a cirurgia ou mesmo a imunoterapia. Sendo invasivos, nos tratamentos oncológicos ocorrem complicações, nomeadamente na boca. A segunda parte do trabalho vai estudar estas manifestações orais, descrevendo as doenças, a fisiopatologia, os fatores de risco, as consequências, finalizando sobre os tratamentos possíveis. Podemos concluir que as informações sobre as manifestações orais são muito importantes para os médicos dentistas a fim de otimizar os cuidados de saúde e delimitar os danos no paciente.Current cancer treatments generally delay or stabilize the disease, but they rarely cure it completely. As a result, patients have to live with the disease, its highly invasive treatments and induced manifestations, which significantly reduces their quality of life. Initially, this work will focus on the functional aspect of the different types of treatments used against cancer, such as chemotherapy, radiotherapy, surgery and immunotherapy. Because they are invasive, oncological treatments usually lead to complications in patients, especially in the mouth. The second part of the work will study these oral manifestations, describing the diseases, their physiopathology, risk factors, consequences, and finally on possible treatments.Les traitements actuels contre le cancer permettent généralement de retarder ou de stabiliser la maladie, mais ils guérissent rarement complètement. Par conséquent, les patients doivent vivre avec la maladie, ses traitements hautement invasifs et ses manifestations induites, ce qui réduit considérablement leur qualité de vie. Dans un premier temps, ces travaux porteront sur le fonctionnement des différents types de traitements utilisés contre le cancer, tels que la chimiothérapie, la radiothérapie, la chirurgie ou encore l'immunothérapie. Étant invasifs, les traitements oncologiques entraînent habituellement des complications chez les patients, en particulier dans la bouche. La deuxième partie du travail étudiera ces manifestations orales, décrivant les maladies, leurs physiopathologie logie, les facteurs de risque, les conséquences, pour finir sur les traitements possibles

The Interprofessional Management Of Geriatric Patients Undergoing Head And Neck Cancer Treatment In U.S. Nursing Homes

A dental approach toward interprofessional management, treatment planning and rehabilitation of diagnosed individuals undergoing cancer therapies is essential. Literature review focuses on presurgery oral hygiene instructions, pre-radiography/chemotherapy dental clearance, complications and management during radiotherapy/chemotherapy; post-radiotherapy/ chemotherapy oral healthcare; and adjunctive measures

Membership Directory and Networking Guide 1991-1992

Membership Directory Members by Location Members by Institutional Typ

Membership Directory and Networking Guide 1991-1992

Membership Directory Members by Location Members by Institutional Typ

Campus & alumni news

Boston University Medicine was published by the Boston University Medical Campus, and presented stories on events and topics of interest to members of the BU Medical Campus community. It followed the discontinued publication Centerscope as Boston University Medicine from 1991-2005, then continued as Campus & Alumni News from 2006-2013 before returning to the title Boston University Medicine from 2014-present

Attempts to Understand Oral Mucositis in Head and Neck Cancer Patients through Omics Studies: A Narrative Review

Oral mucositis (OM) is a common and clinically impactful side effect of cytotoxic cancer treatment, particularly in patients with head and neck squamous cell carcinoma (HNSCC) who undergo radiotherapy with or without concomitant chemotherapy. The etiology and pathogenic mechanisms of OM are complex, multifaceted and elicit both direct and indirect damage to the mucosa. In this narrative review, we describe studies that use various omics methodologies (genomics, transcriptomics, microbiomics and metabolomics) in attempts to elucidate the biological pathways associated with the development or severity of OM. Integrating different omics into multi-omics approaches carries the potential to discover links among host factors (genomics), host responses (transcriptomics, metabolomics), and the local environment (microbiomics)