組織支援에 대한 認識과 組織沒入 및 組織市民行動의 關係에 關한 硏究

학위논문(석사)--서울대학교 대학원 :경영학과 경영학전공,2001.Maste

데카르트에게서 감각과 정념

학위논문(석사)--서울대학교 대학원 :철학과 서양철학전공,1999.Maste

Theorie de Sentiment de Descartes

필자는 논문을 쓰는 동안 데카르트의 철학 안에서 논쟁점이 되는 세 가지 주제를 발견했다. 첫째 주제는 영혼과 신체의 관계의 문제이다. 영혼과 신체는 어떤 관련을 맺고 있는가? 양자는 서로 결합되어 있는가, 아니면 서로 분리되어 독자적으로 존재하는가? 양자는 인과적으로 상호 작용을 하는가, 아니면 양자간의 직접적인 작용은 불가능한가? 둘째 주제는 데카르트의 '감각 내용(sentiment)' 개념과 관련한 그의 '의식(conscience, coscientia)' 혹은 '사유(pensee, cogitatio)'개념이다. 감각 내용은 정신적인 현상인가, 아니면 물질적인 현상인가? 그것은 정신 혹은 의식 없이도 가능한가, 아니면 항상 의식과 관련되어야만 가능한가? 감각 내용이 항상 의식과 관련된 사유의 양태라면 감각 내용과 의식의 관계는 무엇인가? 의식은 항상 감각 내용을 수반하여 그것을 반성적으로 파악하는가, 아니면 의식은 감각 내용을 가능하게 하는 것이지만 실제로는 감각 내용과 분리될 수 없는 하나인가

Prognostic factors of oncologic outcomes after fertility-preservative management with progestin in early-stage of endometrial cancer

Background: The aim of this study was to evaluate efficacy of various fertility-preservative treatments with progestin and analyze prognostic factors in Stage 1A of endometrial cancer. Materials and Methods: This retrospective study involved four Korean university hospitals. Data were collected from 43 women who were under the age of 40 with presumed stage IA endometrial cancer determined by magnetic resonance imaging and treated from January 2014 to December 2017. All of the patients were administered hormonal therapy for fertility preservation. Twenty-five patients received oral progestin with a levonorgestrel-releasing intrauterine system (LNG-IUS) for 6-24 months, and 18 patients received high-dose oral progestin for the same period of time. Oncologic outcomes were evaluated. Prognostic factors for pathologic response to progestin were identified by logistic regression analysis. Results: Complete response (CR) was achieved by 72.1% of patients (31/43), and the average time to CR was 4.2 (Stable disease [SD] 3.4) months (range, 3-9 months). Partial response was achieved by 7.0% of patients (3/43), SD by 9.3% (4/43), and progressive disease by 11.6% (5/43). Of the CR patients, 41.9% (13/31) achieved pregnancy with the median follow-up period of 12.5 (SD 7.6) months (range: 3-50 months). No irreversible toxicity or therapy-associated death occurred. Multivariate analysis showed that high endometrial thickness ratio of pre- and posttreatment measured at 2 months from the treatment initiation (>= 0.55, Odds ratio [OR]: 19.018; 95% confidence intervals (CI): 1.854-195.078; P = 0.013) and oral progestin without LNG-IUS (OR: 13.483; 95% CI: 1.356-134.069; P = 0.026) might be related with unfavorable prognostic factors for CR. Conclusion: This study shows that progestin-based fertility-preservative treatment might be a feasible option for stage 1A endometrial cancer. It also identifies that low endometrial thickness ratio and oral progestin with LNG-IUS combination therapy might be related with favorable response to hormonal treatment

Preoperative Blood Inflammatory Markers for the Differentiation of Uterine Leiomyosarcoma from Leiomyoma

Purpose: Preoperative diagnosis of uterine leiomyosarcoma (LMS) is challenging because the disease can mimic benign leiomyoma (LM). The objective of the present study was to investigate the role of preoperative clinical characteristics and hematologic parameters to differentiate uterine LMS and LM. Methods: Preoperative clinical and laboratory variables were reviewed retrospectively in patients with LMS or LM, and the significances of intergroup differences were assessed. Receiver operating characteristic (ROC) curves were used to determine optimal cut-off values for each variable. Logistic regression analysis was applied to identify variables predicting the presence of LMS. Results: The preoperative clinical and laboratory variables of 336 patients with uterine tumor were analyzed. Seventy-nine patients had LMS and 257 had LM. A significant difference was observed between LMS and LM in terms of the median value of age at diagnosis, menopausal status, white blood cell (WBC) count, absolute neutrophil count (ANC), C-reactive protein (CRP), lactate dehydrogenase (LDH), and neutrophil-tolymphocyte ratio (NLR) (all P < 0.001). Multivariate analyses showed that menopausal status (odds ratio [OR] = 3.40, P= 0.002), WBC count (OR = 2.09, P = 0.012), ANC (OR = 3.17, P < 0.001), CRP (OR = 21.74, P < 0.001), LDH (OR = 10.77, P < 0.001), and NLR (OR = 2.58, P = 0.001) predicted the presence of LMS. Conclusion: Our results suggest that in older or postmenopausal patients, high WBC count, ANC, CRP, LDH, and NLR could be useful biomarkers for the differentiation of LMS and LM, which indicate that serum markers might be useful, cost-effective, and broadly available diagnostic markers for uterine LMS