7 research outputs found
Pulmonary hemorrhage in neonates after treatment with surfactant : An autopsy evaluation
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Although surfactant-replacement therapy reduces morbidity and mortality rates for premature infants, an association between synthetic surfactant therapy and pulmonary hemorrhage has been reported. The purpose of this study was to compare the frequency, extent, and type of pulmonary hemorrhage seen at autopsies of
natural surfactant-treated infants and untreated infants. I reviewed the findings of 39 autopsies - 13 for infants who had received exogenous surfactant and 29 for those who had not. Infants who met the following criteria were included: birth
weight 500 to 2500gm, gestational age 22 to 36 weeks, survival 4 hours to 7 days, and no congenital anomalies. All glass slides were reviewed retrospectively by a single investigator who was unware of the treatment status of the infants.
Pulmonary hemorrhage was classified as interstitial hemorrhage, intraalveolar hemorrhage, and lung hematomas. High rates of pulmonary hemorrhage were present in both groups (all 92.3%).Pulmonary interstitial hemorrhage, intraalveolar hemorrhage and lung hematomas did not differ between the two groups. There was no evidence that surfactant treatment was associated with pulmonary hemorrage.restrictio
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