1930년대말 京畿地域 조선인 대지주의 存在形態

학위논문(석사)--서울大學校 大學院 :國史學科,1995.Maste

Diagnosis of a Cancer with Cancer Stem Cell Property and Composition for Treatment Thereof

알데하이드 디하이드로지네이즈(Aldehyde dehydrogenase, ALDH) 발현 정도를 측정하여 종양줄기세포 특성의 암 진단에 정보를 제공하는 방법, 알데하이드 디하이드로지네이즈 발현 정도를 감소시키는 화합물을 탐색하여 종양줄기세포 특성의 암의 치료제를 스크리닝 하는 방법, 및 알데하이드 디하이드로지네이즈 억제제를 유효성분으로 함유하는 종양줄기세포 특성의 암의 예방 및/또는 치료용 조성물이 제공된다

Agent and method for regulating differentiation in mammals

본 발명은 포유류 배아의 발생 시기에 세포 증식 종료와 분화 개시를 조절하는 메커니즘과 여기에 참여하는 단백질을 밝힌 것으로, 포유류의 분화 조절제, 분화 조절 방법, 상기 분화 조절제의 발현이 손상된 형질전환 동물 및 상기 형질전환 동물의 제조 방법에 관한 것이다

내장형 칩 안테나의 설계와 측정

학위논문(석사) - 한국정보통신대학원대학교 : 공학부, 2003, [ vii, 62 p. ]Recently, with the development of wireless communication components mobile handsets become small and show high performance. The antenna, however, has the physical limitations that its length depends on the wavelength related to frequency so that has some difficulties in miniaturizing. But keeping pace with a trend miniaturizing mobile handsets, many studies are contributed to the small antenna. Especially the internal small antenna attracts much attention. In this thesis, the internal small antenna is proposed and designed. And then the measured and simulated results are represented. The internal small chip antenna for IMT-2000 band is proposed. It has the measured impedance bandwidth of 14% and the measured maximum gain of 1.3dBi. In addition, it shows omni-directional radiation pattern similar to that of monopole so that it can be applicable to IMT-2000 applications Also, an antenna applicable to dual band of PCS and IMT-2000 services attracting much attention in recent years is proposed. The earlier proposed antenna is difficult to fabricate and requires relatively high fabrication costs. However, the proposed antenna in this phase can be fabricated with FR-4 material, which is used to make Printed Circuit Boards (PCBs), through etching process. Therefore it may be highly competitive since it can be easily fabricated and need relatively low fabrication costs. The measured results of the proposed antenna show the impedance bandwidth of 21.4% and the maximum gain of 2.6dBi. It also shows omni-directional radiation pattern so that it is applicable to PCS/IMT-2000 dual band. When an antenna is built in a handset case, its impedance bandwidth may affect so that be out of the desired band. In consideration of this impact the antenna is redesigned. The measured results show the impedance bandwidth of 25.9% and the maximum gain of 2.15dBi. In the same manner, the omni-directional radiation pattern is obtained. Finally, the antenna with built-in source was ...한국정보통신대학원대학교 : 공학부

Dynamic actin remodeling mediates lipid droplet secretion during adipocyte dedifferentiation

Adipocyte plasticity is an important aspect of adipose tissue remodeling in response to changing metabolic demands. Adipocyte dedifferentiation has recently received attention as a mechanism underlying adipocyte plasticity. However, the absence of adequate experimental platforms for studying the cellular mechanisms of adipocyte dedifferentiation has been a constraint. Here, we developed a microscope-mountable ceiling culture chip that enables long-term, high-resolution imaging of adipocytes within a tunable microenvironment. Using this platform, we identified Hippo, Hedgehog, and PPARγ signaling pathways to be potent regulators of adipocyte dedifferentiation via pharmacological or genetic manipulation. Live imaging revealed that dedifferentiating adipocytes undergo dynamic actin remodeling to promote lipid droplet (LD) secretion. An expanding hole in the actin shell surrounding the LD was followed by contraction of the condensed actin shell, resulting in LD extrusion. Unexpectedly, we discovered bidirectional intercellular LD exchange between dedifferentiating adipocytes. Our findings shed light on previously unrecognized molecular and cellular processes that underlie adipocyte dedifferentiation