A Double Blind Crossover Study of Lcxotan

A double blined crossover study of Lexotan was carried out in 40 patients who had been suffered from anxiety neurosis, obsessive-compulsive neurosis, pbobia and psychosomatic disorder. The results were as follows: 1. It was found that Lexotan was far more effective than placebo in the improving the neurotic symptoms. 2. There was no difference between group A (Lexotan gmg/day) and group B (Lexotan 18mg/ day). 3. No difference was found between control and placebo. 4. There was a significant difference between placebo and Lexotan. 5. The slight effectiveness of placebo in L-P group compared with placebo in P-L group was due to an improvement by Lexotan that was given previously, however there was no statistic difference between them. 6. There was no difference in improvement among diagnostic group by Lexotan. 7. Tbe incidence of side effect was relatively low (20%) and most of the side effects(anxiety, agitation, ataxia, drowsiness and dry month) were occured within 48 hours. 8. We had found no abstinence syndromes nor habituation signs in the study

Utilization of Dexamethasone Suppression Test (DST) in Psychiatric Diagnosis

39 subjects (20 normal controls and 19 major depressive patients) underwent an DST to prove the applicability of the test for the diagnosis of major depressive disorder CDSM-II!). Serum cortisol concentrations were determined in duplicate by radioimmunoassay using Amerlex cortisol RIA kit obtained from Amersham International plc, U,K. The results and conclusions are as follows: 1. Pre-dexamethasone serum cortisol concentrations were most increased at 8 : 00 hour decreasing mostly at 23 : 30 both in normal controls and depressive patients, lessening the probability of disrupted eireadian rhythm in the latter. 2. No significant differences of pre-dexamethasone cortisol levels were found between normal controls and depressive patients(by Student's t-test), 3. Significantly decreased suppressibility of serum cortisol levels occurred in depressive patients within 24 hour after dexamethasone (Irng) administration at S : 00 and 16: 00 hour. No difference was found at 23 : 30 hour (by analysis of covariance). 4. The cortisol values after dexamethasone were definitely more specific as discriminators than the corresponding values before dexamethasone. 5. Significant intergroup differences were revealed in the distribution of suppressors and nonsupressors only when the criterion value of serum cortisol level for nonsuppression was supposed to be above Spg/dl (sensitivity: 26%). That was thought to be due to a limited number of study subjects. 6. Differences in age, sex, body weight, psychopathology, family history of mental illness, recurring episodes of major depression, or associated psychotic features had no bearing upon the distribution of suppressors and nonsuppressors (by Fisher's exact test)

(A) study of bernoulli trials

학위논문(석사) - 한국과학기술원 : 산업공학과, 1976.2, [ [ii], 53 p. ]In application of the properties of Bernoulli trials the parameters are usually unknown and have to be estimated from the sample. This thesis discusses the probability distributions and the problems of parameter estimation under different dependence relations among the Bernoulli trials. Specifically, an independent trials model and a model with dependence relations between successive trials are considered. For each model three sampling plans or stopping rules are discussed. Sampling plan $S_1$ : a preassigned number of observations are taken. Sampling plan $S_2$ : observations are continued until a preass igned number m of successes are obtained. Sampling plan $S_3$ : observations are continued until at least $m_1$ success and $m_2$ failures are obtained where $m_1$ and $m_2$ are preassigned numbers. For each combination of dependent structures and sampling plans, relevant probability distributions and moments, are studied, and sufficient statistics and simple estimators for the parameters are presented. Especially this thesis synthesizes and complements the results of the previous studies done by many authors and studies in detail properties of the new sampling plan $S_3$.한국과학기술원 : 산업공학과

An MMPI Normative Study on Korean Adolescents

The MMPI booklet form of 566 items were administered to total 2,212 0 , 081 male, L 131 female) middle and high school students in Seoul (metropo! i tan), Sungnam (city) and Yangyang (rural) areas in order to secure Korean adolescent MMPI norms. The major findings are as follows: 1. Their mean T -scores of each scale do not deviate much from the adolescent norms currently in use in Korea although elevations on Sc and Ma scales are noticed. 2. The male students are found to have higher T·scores on almost every scales compared to the females , particularly so on F, Pa, Pt Sc and scales 3. The high school students tend to show slightly higher elevation compared to the middle school students on almost all scales, particularly on Ma while low on K scale 4. Rural students are found to to be more vulnerable in their mental health, indicated by generally more elevated clinical scales, particularly Pa, Pt , Sc and Si, as well as higher Anxiety Index , lower Ego Srength and higher Internalization Ratio 5. 24.27 percent of total adolescent students has either one-point or two-point high-point codes, most frequent scales among them being Sc and Si scale. High-point codes are associated with more males than females , more high school students than middle school ones, and more rural students than Seoul or city ones. 6. Generally male students can be said to be more loaded with psychological burden than the females, particularly those middle school students in rural area and high school students in Seoul. Implications of the above findings are discussed in view of developmental differences between male and female students, sociocultural aspect, and greater psychological burden and stress on the part of male students

Effect of Corticosterone on the Contents of Norepinephrine, Dopamine and Serotonin in the Rat Brain

It has been well known that glucocorticoid hormone can induce mental symptoms, mainly depressive or manic symptom. And many investigators suggest that some change in the monoamine contents can induce affective disorders, In this study, in order to investigate the effect of corticosterone on the brain monoamines in rats, the contents of norepinephrine(NE), dopamine(DA) and 5-hydroxy·tryptamine(5-HT) were determined fluorophotometrically two and seven days after adrenalectomy and we also checked the contents of monoamines before and after administration of corticosterone to adrenalectomized rats. The results are summarized as follows. 1) Two and seven days after adrenalectomy, there were decreases in NE and DA contents and an increase in 5-HT con ten t. 2) Administration of corticosterone in adrenalectomized rats caused increases in the concentrations of NE and DA, hut caused decrease in that of 5-HT. 3) The concentration of monoarnines were more markedly changed two days after adrenalectomy than seven days. 1) Changes in the concentrations of 5-HT were relatively dose-dependent but those of NE and DA were not so definite as 5-HT. In conclusion, it is strongly suggested that corticosterone may significantly affect the contents of dop· amine, norepinephrine and S-hydroxytryptamine in several regions of rat brain and these changes may playa role in the mechanism of steroid related mental symptoms

Effect of Lithium Carbonate on the Concentrations of Monoamine Neurotransmitters in the Rat Brain

An experimental study was performed to elucidate the mechanism of therapeutic effect of lithium in the manic-depressive illness using 174 male SpragueDawley rats. The concentrations of lithium in plasma, erythrocyte, and brain tissue and the concentrations of norepinephrine, dopamine, and 5 hydroxytryptamine in the whole brain of rats were measured following single dose (3mM or/6mM kg. wt.) or repeated administrations (3mM/kg/day, for 3 days, 7 days, and 14 days) of lithium carbonate through mouth. 1. The correlation between plasma lithium and brain lithium levels was slightly higher than that between erythrocyte lithium and brain lithium levels. 2. Following single dose of lithium carbonate, the concentrations of norepinephrine, dopamine and 5-hydroxytryptamine were not changed significantly from those of the controis. 3. Following repeated administrations (more than 3 days) of lithium carbonate, the concentration of 5 hydroxytryptamine was significantly elevated, but the concentrations of norepinephrine and dopamine were not changed significantly from those of controls. 4. When the lithium administrations were combined with the intraperitoneal injection of a tyrosine hydroxylase inhibitor, a-methylparatyrosine or a tryptophan hydroxylase inhibitor, para-chlorophenylalanine, there was a tendency of elevation of concentrations of all 3 amines. Above results indicated that the plasma lithium values reflected better the lithium concentration of the brain than erythrocyte lithium values, and that the lithium lowers the activities of norepinephrine, dopamine and 5- hydroxytryptamine neurone in the brain and may affect the synthesis of thess monoamines. These lowering effect of lithium might be related to the therapeutic effect of lithium in manicdepressive illness

전기경변추동에 의한 흰쥐뇌 Phosphoinositide-specific Phospholipase C의 량적 변화에 관한 연구

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An Epidemiological Survey of Major Mental Disorders in a rural Korea

In July and August 1979. an epidemiological survey was conducted using the census visit method in order to determine the prevalence rate and ecological aspects of 5 major mental illnesses (schizoph· renia, manic·depressive illness, epilepsy, mental retardation and senile psychosis) in Ko·Jae Island where the total population was 112. 782. Following results were obtained: }. The prevalence rate for schizophrenia. manic-depressive illness, epilepsy. mental retardation and senile psychosis were O. 14%. 0.013%. O. 10%. O. 10 %. 0.03% of population respectively. 2. 65.6% of schizophrenics. 66.7% of rnanic-depressive illness patients and 76.9% of epileptics had suffered for more than 5 years. 3. The mixed body type was dominant in number both in schizophrenia and manic·depressive illness. 4. The familial history was found in 13.0% of schizophrenics and 26.7% of manic-depressive illness patients. 5. In therapy. 49.1% of epileptics take anticonvulsant and 37% of schizophrenics and 33. 3% of manicdepressive illness patients were left alone without custodial cares