55 research outputs found
์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ์ ํจ๊ณผ๋ฅผ ์ค์ฌ์ผ๋ก
ํ์๋
ผ๋ฌธ (์์ฌ) -- ์์ธ๋ํ๊ต ๋ํ์ : ์ฌํ๊ณผํ๋ํ ์ฌ๋ฆฌํ๊ณผ, 2021. 2. ์ดํ์ง.๋ณธ ์ฐ๊ตฌ์์๋ ๋ถ๋ฆฌ๊ฐ๋ณํ์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ์ด ์ ์์กฐ์ ๊ณค๋๊ณผ ํญ์ ๋ฐ ์ํด ํ๋์ ๋ฏธ์น๋ ์ํฅ์ ํ์ํ๊ณ , ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ๊ฐ ์๊ธฐ์๋ก ๋ฅ๋ ฅ์ ์ฆ์ง๊ณผ ์ ์์กฐ์ ๊ณค๋๊ณผ ํญ์ ๋ฐ ์ํด ํ๋์ ๊ฐ์ ์ ํจ๊ณผ์ ์ธ์ง ํ์ธํ๊ณ ์ ํ์๋ค.
์ฐ๊ตฌ 1์์๋ ๋ํ์ 238๋ช
์ ๋์์ผ๋ก ๋ถ๋ฆฌ๊ฐ๋ณํ, ์๊ธฐ์๋ก ๋ฅ๋ ฅ, ์ ์์กฐ์ ๊ณค๋๊ณผ ํญ์ ๋ฐ ์ํด ํ๋์ ๊ด๊ณ๋ฅผ ํ์ธํ์๋ค. ๋ถ์ ๊ฒฐ๊ณผ, ๋ถ๋ฆฌ๊ฐ๋ณํ๋ ์๊ธฐ์๋ก ๋ฅ๋ ฅ๊ณผ ์ ์ ์๊ด์, ์ ์์กฐ์ ๊ณค๋๊ณผ ํญ์ ๋ฐ ์ํด ํ๋๊ณผ๋ ๋ถ์ ์๊ด์ ๋ณด์๋ค. ๋ํ, ๋ถ๋ฆฌ๊ฐ๋ณํ๊ฐ ํญ์ ํ๋์ ๋ฏธ์น๋ ์ํฅ์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ๊ณผ ์ ์์กฐ์ ๊ณค๋์ด ์์ฐจ์ ์ผ๋ก ๋งค๊ฐํ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ๋ถ๋ฆฌ๊ฐ๋ณํ์ ์ํด ํ๋ ๊ฐ ๊ด๊ณ์์๋ ์๊ธฐ์๋ก ๋ฅ๋ ฅ์ ๋งค๊ฐํจ๊ณผ๋ง ๋ํ๋ฌ์ผ๋, ์ํด ๊ฒฝํ์ด ์๋ ๋ํ์๋ง์ ๋์์ผ๋ก ๋ถ์ํ์ ๋์๋ ์๊ธฐ์๋ก ๋ฅ๋ ฅ๊ณผ ์ ์์กฐ์ ๊ณค๋์ ์์ฐจ ๋งค๊ฐํจ๊ณผ๊ฐ ์ ์๋ฏธํ๋ค.
์ฐ๊ตฌ 2์์๋ ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ ์ฒ์น๋ฅผ ํตํ์ฌ ์๊ธฐ์๋ก ๋ฅ๋ ฅ์ ์ฆ์ง๊ณผ ์ ์์กฐ์ ๊ณค๋ ๋ฐ ํญ์ ํ๋, ์ํด ํ๋์ ๊ฐ์ ์ ๋ชจ์ํ์๋ค. ๋ํ์ 42๋ช
์ ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ ์ง๋จ ๋ฐ ํํ์ ๊ธ์ฐ๊ธฐ ์ง๋จ์ ๋ฌด์ ํ ๋นํ์ฌ 4์ผ๊ฐ ์ด ๋ค ๊ฐ์ง ์ฃผ์ ๋ก ๊ธ์ฐ๊ธฐ ์ฒ์น๋ฅผ ์ค์ํ์๊ณ , ์ฒ์น ์ ํ๋ก ๋ถ๋ฆฌ๊ฐ๋ณํ, ์๊ธฐ์๋ก ๋ฅ๋ ฅ, ์๊ธฐ์๋น, ์ ์์กฐ์ ๊ณค๋, ํญ์ ๋ฐ ์ํด ํ๋์ ์ธก์ ํ์๋ค. ๊ทธ ๊ฒฐ๊ณผ, ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ ์ง๋จ์์ ์ฒ์น ์ ํ๋ก ๋ถ๋ฆฌ๊ฐ๋ณํ์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ์ ์ ์๋ฏธํ ์ฆ์ง์ด ๋ํ๋ฌ์ผ๋ฉฐ, ํํ์ ๊ธ์ฐ๊ธฐ ์ง๋จ์ ๋นํด ๋ถ๋ฆฌ๊ฐ๋ณํ์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ์ ์ฆ์ง ์ ๋๊ฐ ์ ์ํ๊ฒ ์ปธ๋ค. ์์ธ๋ฌ, ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ ์ง๋จ์์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ ๋ฐ ์๊ธฐ์๋น์ ์ฆ์ง ์ ๋๋ ์ ์์กฐ์ ๊ณค๋์ ๊ฐ์ ์ ๋์ ์ ์ํ ์๊ด์ ๋ณด์๋ค. ํํ์ ๊ธ์ฐ๊ธฐ ์ง๋จ์์๋ ์ฒ์น ์ ํ๋ก ์ ์์กฐ์ ๊ณค๋์ ์ ์๋ฏธํ ๊ฐ์๊ฐ ๋ํ๋ฌ๋ค.
๋ณธ ์ฐ๊ตฌ๋ ๋ถ๋ฆฌ๊ฐ๋ณํ์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ์ด ์ ์์กฐ์ ๊ณค๋๊ณผ ํญ์ ๋ฐ ์ํด ํ๋์ ๋ฏธ์น๋ ์ํฅ์ ํ์ํ๊ณ , ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ์ ํจ๊ณผ๋ฅผ ํ์ธํ์๋ค๋ ๋ฐ ์์๊ฐ ์๋ค. ๋ง์ง๋ง์ผ๋ก ๋ณธ ์ฐ๊ตฌ์ ํจ์, ํ๊ณ์ ๋ฐ ์ถํ ์ฐ๊ตฌ์ ๋ํ ์ ์ธ์ ๋
ผ์ํ์๋ค.The present study was conducted to explore the influence of separation-individuation and self-soothing ability on emotional dysregulation, binge-eating and self-harm behaviors, and the effect of compassionate letter writing intervention for improving self-soothing ability and decreasing emotional dysregulation, binge-eating and self-harm behaviors.
In study 1, the relationships among separation-individuation, self-soothing ability, emotional dysregulation, and binge-eating and self-harm behaviors were examined in a sample of 238 college students. The results showed that separation-individuation was positively correlated with self-soothing ability, and negatively correlated with emotional dysregulation, binge-eating and self-harm behaviors. Self-soothing ability and emotional dysregulation mediated the effect of separation-individuation on binge-eating behavior sequentially. Only self-soothing ability, not emotional dysregulation, mediated the effect of separation-individuation on self-harm behavior. However, in a sample of 89 participants who have experienced self-harm, the sequential mediating effect of self-soothing ability and emotional dysregulation in the relationship between separation-individuation and self-harm behavior was significant.
In study 2, the effect of compassionate letter writing intervention on self-soothing ability, emotional dysregulation, binge-eating and self-harm behaviors was explored. Forty-two college students were randomly assigned to two groups: compassionate letter writing group and expressive writing group. The writing interventions were performed on four themes for four consecutive days. There was significant increase of separation-individuation and self-soothing ability in the compassionate letter writing group, and the compassionate letter writing group showed more increase in separation-individuation and self-soothing ability than the expressive writing group. In the compassionate letter writing group, there were significant correlations between the changes in self-soothing ability and self-compassion and the changes in emotional dysregulation. There was significant decrease of emotional dysregulation in the expressive writing group.
The present study not only explored the influence of separation-individuation and self-soothing ability on emotional dysregulation and impulsive behavior problems such as binge-eating and self-harm behaviors, but also investigated the effectiveness of compassionate letter writing intervention. The implications and limitations of this study and suggestions for further study were also discussed.์ ๋ก 1
๋ถ๋ฆฌ๊ฐ๋ณํ์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ 3
๋ถ๋ฆฌ๊ฐ๋ณํ ๋ฐ ์๊ธฐ์๋ก ๋ฅ๋ ฅ๊ณผ ์ถฉ๋ํ๋ ๋ฌธ์ 5
๋ถ๋ฆฌ๊ฐ๋ณํ ๋ฐ ์๊ธฐ์๋ก ๋ฅ๋ ฅ๊ณผ ์ถฉ๋ํ๋ ๋ฌธ์ ๊ฐ์ ๊ด๊ณ์์ ์ ์์กฐ์ ๊ณค๋์ ์ญํ 7
์๊ธฐ์๋น ํ๋ จ์ ํตํ ์๊ธฐ์๋ก ๋ฅ๋ ฅ ์ฆ์ง์ ํ์์ฑ: ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ๋ฅผ ์ค์ฌ์ผ๋ก 9
๋ฌธ์ ์ ๊ธฐ ๋ฐ ์ฐ๊ตฌ ๋ชฉ์ 13
์ฐ๊ตฌ 1. ๋ถ๋ฆฌ๊ฐ๋ณํ์ ํญ์ ๋ฐ ์ํด ํ๋ ๊ฐ ๊ด๊ณ์์ ์๊ธฐ์๋ก ๋ฅ๋ ฅ ๋ฐ ์ ์์กฐ์ ๊ณค๋์ ์ญํ 15
๋ฐฉ ๋ฒ 17
๊ฒฐ ๊ณผ 21
๋
ผ ์ 27
์ฐ๊ตฌ 2. ์๋น๋ก์ด ํธ์ง์ฐ๊ธฐ๊ฐ ์๊ธฐ์๋ก ๋ฅ๋ ฅ, ์ ์์กฐ์ ๊ณค๋, ํญ์ ๋ฐ ์ํด ํ๋์ ๋ฏธ์น๋ ํจ๊ณผ 30
๋ฐฉ ๋ฒ 33
๊ฒฐ ๊ณผ 38
๋
ผ ์ 45
์ข
ํฉ ๋
ผ์ 50
์ฐธ๊ณ ๋ฌธํ 57
๋ถ๋ก 71
Abstract 105Maste
ํธ์ธก ๋ฐ ์์ธก ์ ๋ง๊ฑฐ์์ ๋ฐ๋ฅด๋ ๋น์ค๊ฒฉ ์ฐ๊ณจ์ ํํํ์ ๋ฐ ์กฐ์งํ์ ๋ณํ
ํ์๋
ผ๋ฌธ (์์ฌ)-- ์์ธ๋ํ๊ต ๋ํ์ : ์ํ๊ณผ, 2012. 8. ์งํ๋ฅ .์๋ก
ํธ์ธก ๋ฐ ์์ธก ๋น์ค๊ฒฉ ์ ๋ง๊ฑฐ์์ผ๋ก ์ธํ ๋น์ค๊ฒฉ ์ฐ๊ณจ์ ํํํ์ , ์กฐ์งํ์ ๋ณํ๋ฅผ ์ฐ๊ตฌํ๊ณ ์ ํ์๋ค.
์ฌ๋ฃ ๋ฐ ๋ฐฉ๋ฒ
์ฑ์ํ ์์ปท ๊ฐํ (New Zealand rabbit) 18๋ง๋ฆฌ๋ฅผ ์ ๊ธฐ์ ๋ฐ๋ผ ๋ฌด์์๋ก ํธ์ธก ๋น์ค๊ฒฉ ์ ๋ง๊ฑฐ์๊ตฐ, ์์ธก ๋น์ค๊ฒฉ ์ ๋ง๊ฑฐ์๊ตฐ, ์๋ฌด ์กฐ์๋ ํ์ง ์๋ ๋น๊ต๊ตฐ์ ์ธ ๊ทธ๋ฃน์ผ๋ก ๋๋์๋ค. ๊ฐ๊ฐ์ ๊ทธ๋ฃน ์ค 3๋ง๋ฆฌ๋ ์์ 3๊ฐ์ ๋ค, ๋๋จธ์ง 3๋ง๋ฆฌ๋ 6๊ฐ์ ๋ค ํฌ์์์ผฐ๋ค. ๋น์ค๊ฒฉ ์ฐ๊ณจ์ ํํ๋ฅผ ๊ด์ฐฐํ๊ณ , ๋๊ป๋ฅผ ์ธก์ ํ์์ผ๋ฉฐ H&E ์ผ์, Massons trichrome ์ผ์, Alcian blue ์ผ์, Verhoeffs elastic ์ผ์์ ํตํด ์กฐ์งํ์ ์๊ฒฌ์ ๋น๊ต ๋ถ์ํ์๋ค.
๊ฒฐ๊ณผ
๋น์ค๊ฒฉ ์ฐ๊ณจ์ ๋ชจ์๊ณผ ๋๊ป๋ ์ธ ๊ตฐ๊ฐ์ ์ ์ํ ์ฐจ์ด๋ฅผ ๋ณด์ด์ง ์์๋ค. ๋น์ค๊ฒฉ ์ฐ๊ณจ ๋ด ์ฐ๊ณจ์ธํฌ์ ์, ์ธํฌ์ด์๋ณํ (dystrophic change), ์ฐ๊ณจ์ธํฌ์ ๋ํ ์ฐ๊ณจ๋ชจ์ธํฌ์ ๋น์จ๋ ์ธ ๊ตฐ๊ฐ์ ๋ชจ๋ ์ ์ํ ์ฐจ์ด๋ฅผ ๋ณด์ด์ง ์์๋ค. ๋ฐ๋ฉด ์ธํฌ์ธ ๊ธฐ์ง์ ์์ธก ์ ๋ง๊ฑฐ์์ ์ํํ ๊ตฐ์์ ์ฐํ๊ฒ ์ผ์๋์๊ณ ํนํ ์ฝ๋ผ์ ์ฌ์ (collagen fiber)๊ฐ ์ ์ํ๊ฒ ๋ถ์กฑํ์๋ค.
๊ฒฐ๋ก
์์ธก ๋น์ค๊ฒฉ ์ ๋ง๊ฑฐ์๊ตฐ์ ํธ์ธก ์ ๋ง๊ฑฐ์๊ตฐ๊ณผ ๋น๊ตํ์ฌ ๋น์ค๊ฒฉ ์ฐ๊ณจ์ ํํ, ๋๊ป ๋ฐ ์ฐ๊ณจ ๋ด ์ธํฌ์ ํน์ฑ์๋ ์ํฅ์ ๋ฏธ์น์ง ์์ง๋ง ์ฝ๋ผ๊ฒ์ฌ์ ์ ๊ฐ์๋ฅผ ๊ฐ์ ธ์จ๋ค.Introduction
The effect of unilateral versus bilateral elevation of mucoperichondrium on the morphological and histological changes of septal cartilage was evaluated.
Materials and methods
Eighteen mature New Zealand white rabbits were categorized into three groups according to the procedures they received: unilateral mucoperichondrial flap elevation (N = 6) vs bilateral mucoperichondrial flap elevation (N = 6) vs control (no flap elevation, N = 6). In each group, half of the subjects were sacrificed 3 months after the procedure and the other half 6 months after the procedure. Thickness was measured on the optical microscope image and histologic changes of chondrocyte and extracellular matrix were evaluated using H&E stain, Massons trichrome stain, Alcian blue stain, and Verhoeffs elastic stain.
Results
The three groups showed similarity in terms of thickness of the cartilage. Histologic examination revealed that the chondrocyte numbers and dystrophic feature as well as the ratio of chondroblast were not different among the 3 groups. Massons trichrome staininng of extracellular matrix in bilateral group showed less dense collagen fibers than the unilateral group. Proteoglycan and elastic fiber composition did not differ among the 3 groups.
Conclusion
Bilateral mucoperichondrial flap elevation of the septum results in less dense collagen fibers in the extracellular matrix, although the thickness of cartilage, the characters of chondrocyte and chondroblast and other extracellular matrix component remain about the same.I. Introductionโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ..โฆโฆโฆโฆโฆ...โฆโฆ.1
II. Materials and methodsโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆ...โฆโฆ.....4
Animal surgeryโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆโฆโฆ..4
Specimen Harvestโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆ..5
Preparation for histologic examinationโฆโฆโฆโฆโฆ.โฆโฆ..6
Thickness of cartilageโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆโฆ6
Histologic examinationโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆโฆ..6
Statistical analysisโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆโฆ..7
III. Resultsโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆโฆ.8
Thickness of cartilageโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆโฆ8
Histologic examinationโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆ..8
1. Chondrocyte and chondroblastโฆโฆโฆโฆโฆโฆ..โฆโฆ8
2. Extracellular matrixโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ...9
IV. Discussionโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ.โฆโฆ.โฆโฆ..10
V. Conclusionโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ..โฆโฆโฆโฆโฆ.14
VI. Referencesโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ...โฆโฆโฆโฆโฆโฆโฆ.15
VII. ๊ตญ๋ฌธ์ด๋กโฆโฆโฆโฆโฆโฆโฆโฆโฆโฆ...โฆโฆโฆโฆโฆโฆโฆ...........28Maste
SPARC ์์ฉ 32-๋นํธ ๋ง์ดํฌ๋ก ์ปจํธ๋กค๋ฌ ์ฐน์ฉ ๋ฉ๋ชจ๋ฆฌ ์ ์ด๊ธฐ์Microcontroller chip
Maste
(The)Effect of film thickness on the dielectric properties of PbTiO3 thin films
Thesis (master`s)--์์ธ๋ํ๊ต ๋ํ์ :์ฌ๋ฃ๊ณตํ๋ถ,2004.Maste
A Study on the content system of language arts
ํ์๋
ผ๋ฌธ(๋ฐ์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :๊ตญ์ด๊ต์ก๊ณผ ๊ตญ์ด๊ต์ก์ ๊ณต,1998.Docto
MEC ํ๊ฒฝ์์์ ๋คํธ์ํฌ ์๋น์ค ์์ ํ ๋น ์๋ํ ๋ฐฉ๋ฒ
DoctorIn the 5G era, it is necessary to provide services to many devices connected to the networks while meeting diverse demands, such as high availability, low latency, and high data rates. Multi-access edge computing (MEC), one of the key technologies to achieve the goal, brings down the cloud-computing capabilities to network edges near users. The MEC environment provides resources allocated for the service operations and mitigates the core networkโs load by processing traffic at the edge of networks. Service running in the edges usually consists of multiple components interacting with each other because this architecture enables flexible and rapid service provisioning. However, those MEC and service architecture complicate the service operations due to many factors. Specifically, it is essential to consider the limited resources of edges and the location in which services run while satisfying the QoS requirements. In addition, it is hard to operate services manually in response to dynamic traffic. Therefore, we propose an auto-scaling method using deep Q-network (DQN) in this thesis. The proposed method runs the adequate number of instances, that is, resources, composing service while considering the service performance and operating costs. The proposed approach consists of two models: the DQN model making scaling decisions, and the decision model choosing components (or locations) to be scaled. We implemented an auto-scaler as a module to allocate instances (virtual machines or containers) to service in the MEC environments. Our proposed method was validated by conducting several experiments with different scenarios.์ ๋ง์ ๊ธฐ๊ธฐ๋ค์ด ์ฐ๊ฒฐ๋๋ 5G ๋คํธ์ํฌ์์๋ ์ด๊ด๋์ญ ์๋น์ค, ๊ณ ์ ๋ขฐ ๋ฐ ์ด์ ์ง์ฐ ํต์ ์ ์ ๊ณตํ๋ ๊ฒ์ด ์๊ตฌ๋๋ค. MEC (Multi-access Edge Computing)๋ ์ด๋ฅผ ์คํํ๊ธฐ ์ํ ํต์ฌ ๊ธฐ์ ์ค ํ๋๋ก, ํด๋ผ์ฐ๋ ์ปดํจํ
ํ๊ฒฝ์ ์ฌ์ฉ์์ ๊ฐ๊น์ด ๋คํธ์ํฌ ์ฃ์ง (Edge), ์ฆ, ๊ธฐ์ง๊ตญ์ ๋ฐฐ์นํ๋ ๋ฐฉ๋ฒ์ด๋ค. MEC๋ ์๋น์ค ์ด์ฉ์ ์ํ ์ปดํจํ
ํ๊ฒฝ์ ์ ๊ณตํ ๋ฟ๋ง ์๋๋ผ, ๋คํธ์ํฌ ์ข
๋จ์์ ํธ๋ํฝ์ ์ฒ๋ฆฌํจ์ผ๋ก์จ ์ฝ์ด ๋คํธ์ํฌ๋ก ์ ๋ฌ๋๋ ํธ๋ํฝ์ ๊ฐ์์์ผ ๋คํธ์ํฌ ๋ถํ๋ฅผ ์ค์ผ ์ ์๋ค๋ ์ฅ์ ์ด ์๋ค. ์ผ๋ฐ์ ์ผ๋ก MEC ํ๊ฒฝ์์ ์ด์ฉ๋๋ ์๋น์ค๋ค์ ์ ์ฐํ ๊ด๋ฆฌ์ ์ ์ํ ๋ฐฐํฌ๋ฅผ ์ํด ๋ง์ดํฌ๋ก์๋น์ค (Microservice) ๊ตฌ์กฐ๋ก ์ค๊ณ๋๋ฉฐ, ์๋น์ค๋ฅผ ๊ตฌ์ฑํ๋ ๋ง์ดํฌ๋ก์๋น์ค๋ค์ ๋
๋ฆฝ์ ์ธ ๊ธฐ๋ฅ์ ์ํํ๋ฉฐ ๋ค๋ฅธ ์ข
๋ฅ์ ๋ง์ดํฌ๋ก์๋น์ค์ ์ํธ ํต์ ํ๋ค.
MEC ํ๊ฒฝ๊ณผ ๋ง์ดํฌ๋ก์๋น์ค ๊ตฌ์กฐ๋ ์๋น์ค ์๊ตฌ์ฌํญ์ ๋ฐ๋ผ ์ ํฉํ ์์น์ ์์ฝ๊ฒ ์๋น์ค๋ฅผ ๋ฐฐํฌํ ์ ์๋ค๋ ์ฅ์ ์ด ์์ง๋ง, ํํธ์ผ๋ก๋ ์๋น์ค ์ด์ฉ์ ๋ณต์กํ๊ฒ ๋ง๋๋ ์์ธ์ด ๋๋ค. ํนํ, MEC ํ๊ฒฝ์ ์ผ๋ฐ์ ์ธ ๋ฐ์ดํฐ์ผํฐ ํ๊ฒฝ๊ณผ๋ ๋ฌ๋ฆฌ ์ ํ๋ ์ปดํจํ
์์์ ๊ฐ๊ณ ์๊ธฐ ๋๋ฌธ์ ์ฃผ์ด์ง ์์์ ํจ์จ์ ์ผ๋ก ํ์ฉํ๋ ๊ฒ์ด ํ์์ด๋ค. ๋ํ, ๋ง์ดํฌ๋ก์๋น์ค ๊ตฌ์กฐ๋ก ์ค๊ณ๋ ์๋น์ค๋ ๊ฐ ๊ธฐ๋ฅ๋ณ๋ก ๋ชจ๋ํ๋ ๋ง์ดํฌ๋ก์๋น์ค๋ฅผ ํตํด ์ธ๋ฐํ ์ด์ฉ์ด ๊ฐ๋ฅํ๊ธฐ ๋๋ฌธ์, ๋์ ์ผ๋ก ๋ณํ๋ ๋คํธ์ํฌ ํธ๋ํฝ์ ๋์ํ์ฌ ์๋น์ค ์ฑ๋ฅ์ ๋ณด์ฅํ๊ธฐ ์ํ ์ ์ ๋์ ์์์ ๋ง์ดํฌ๋ก์๋น์ค์ ํ ๋นํ๋ ๊ฒ์ด ํ์ํ๋ค. ์ฆ, MEC ํ๊ฒฝ์์์ ์๋น์ค ์ด์ฉ์ ์๋น์ค์ ์ฑ๋ฅ ๋ฟ ์๋๋ผ, MEC ํ๊ฒฝ์ ๊ฐ์ฉ ์์, ์๋น์ค์ ํ ๋น๋ ์์๊ณผ ์ด์ฉ ๋น์ฉ ๋ฑ์ ๋ณตํฉ์ ์ผ๋ก ๊ณ ๋ คํด์ผ ํ๋ค. ํ์ง๋ง, ๋ณต์กํ MEC ํ๊ฒฝ์์ ๊ด๋ฆฌ์์ ํ๋จ์ ๋ฐ๋ผ ์์์
์ผ๋ก ์๋น์ค๋ฅผ ์ด์ฉํ๋ ๊ฒ์ ์ด๋ ค์ด ์ผ์ด๋ค.
๋ณธ ๋
ผ๋ฌธ์์๋ ์์ ๊ฐ์ ๋ฌธ์ ๋ฅผ ํด๊ฒฐํ๊ธฐ ์ํด ๊ฐํํ์ต ๊ธฐ๋ฐ์ ์คํ ์ค์ผ์ผ๋ง (Auto-scaling) ๋ฐฉ๋ฒ์ ์ ์ํ๋ค. ์ ์ํ๋ ๋ฐฉ๋ฒ์ ์ฌ์ธต ๊ฐํํ์ต ์๊ณ ๋ฆฌ์ฆ์ธ DQN (Deep Q-network)์ ํ์ฉํ์ฌ ํ์ฌ ์ด์ฉ ์ค์ธ ์๋น์ค์ ์ปดํจํ
์์ ์ฌ์ฉ๋, ์ด์ฉ ๋น์ฉ, ์ฑ๋ฅ ๋ฑ์ ๊ณ ๋ คํ์ฌ ์๋น์ค์ ํ ๋น๋๋ ์์์ ์กฐ์ ํ๋ค. ์ด ๋, ์๋น์ค ์ด์ฉ์ ์ํ ์์์ ๋ง์ดํฌ๋ก์๋น์ค๋ก ๋์ํ๋ ์ธ์คํด์ค๋ฅผ ์๋ฏธํ๋ฉฐ, ์ ์ํ๋ ๋ฐฉ๋ฒ์ ์ํ์ ์ค์ผ์ผ๋ง (Horizontal scaling) ์ธก๋ฉด์์ ์๋น์ค์ ํ ๋น๋ ์ธ์คํด์ค์ ๊ฐ์๋ฅผ ์กฐ์ ํ๋ค. ๋ํ, ๋ณธ ๋
ผ๋ฌธ์ ์คํ ์ค์ผ์ผ๋ง ๋ฐฉ๋ฒ์ ์ค์ผ์ผ๋ง ์ฌ๋ถ๋ฅผ ๊ฒฐ์ ํ๋ DQN ๋ชจ๋ธ ๋ฟ ์๋๋ผ, MEC ํ๊ฒฝ์ ๊ฐ์ฉ ์์, ์๋น์ค ์ฑ๋ฅ ๋ฑ์ ๊ณ ๋ คํ์ฌ ์ค์ผ์ผ๋ง ๋์์ด ๋๋ ์ธ์คํด์ค ๋ฐ ์์น๋ฅผ ๊ฒฐ์ ํ๋ ๊ฒฐ์ ๋ชจ๋ธ (Decision model)์ ํฌํจํ๋ค. ์ ์๋ ๋ฐฉ๋ฒ์ ๊ฐ์ ๋จธ์ (VM, Virtual Machine)๊ณผ ์ปจํ
์ด๋ (Container)๋ค๋ก ๊ตฌ์ฑ๋๋ ์๋น์ค๋ฅผ ๋์์ผ๋ก ์คํ ์ค์ผ์ผ๋ง์ ์ ์ฉํ ์ ์๋ ๋ชจ๋ ํํ๋ก ๊ตฌํ๋์๋ค. ์ ์ํ ๋ฐฉ๋ฒ์ MEC ํ๊ฒฝ์ ๊ฐ์ ํ์ฌ ๊ตฌ์ถ๋ ์คํํ๊ฒฝ์์ ๋ค์ํ ์๋๋ฆฌ์ค๋ฅผ ํตํด ์ฑ๋ฅ ํ๊ฐ๋ฅผ ์ํํ์์ผ๋ฉฐ, ๊ฐ ์๋๋ฆฌ์ค ๋ณ๋ก ์ ์ํ ๋ฐฉ๋ฒ์ด ์ ์ ๊ฐ์์ ์ธ์คํด์ค๋ฅผ ์ ์งํ๋ฉฐ ์์ ์ ์ธ ์๋น์ค ์ฑ๋ฅ์ ๋ณด์ฅํ๋ ๊ฒ์ผ๋ก ๊ฒ์ฆ๋์๋ค
A Study on the formal conformance testing of a protocol based on the communicating extended FMS model
Docto
๋๊ฒฝ๋ถ ํธํ์ํผ์ธํฌ์์ ๋ํ 5-FU์ celecoxib ๋ณํฉ์น๋ฃ์ ํจ๊ณผ์์ ํ์ฑ์ฐ์์ ์ญํ ์ ๋ํ ์ฐ๊ตฌ
ํ์๋
ผ๋ฌธ (๋ฐ์ฌ)-- ์์ธ๋ํ๊ต ๋ํ์ : ์ํ๊ณผ, 2017. 2. ๊น์ํธ.Introduction: The role of celecoxib in preventing and treating tumors has attracted broad attention in recent years because of its selective and specific inhibition of COX-2 activity. We investigated the inhibitory effects and mechanisms of celecoxib combined with 5-FU on proliferation of squamous cell carcinoma cells in vivo and in vitro.
Methods: SNU-1041 and SNU-1076 squamous cell lines and an orthotopic tongue cancer mouse model were used to study growth inhibition with 5-FU enhanced by celecoxib. Sensitivity of cells to drug treatment was analyzed by the MTT assay, and generation of reactive oxygen species (ROS) was measured using dichlorofluorescein diacetate (DCFH-DA). Phosphorylation of AKT was detected by Western blotting. Survival analysis in the mouse model was assessed according to combination treatment with 5-FU and celecoxib.
Results: ROS production in vitro was highest when celecoxib was administered 48 hours after 5-FU treatment. 5-FU-induced inhibition of cell proliferation was enhanced when combined with celecoxib, which was positively correlated with ROS production. Antioxidant treatment reversed 5-FU-inhibited cell proliferation by up to 60%. Co-treatment with celecoxib and 5-FU partially blocked AKT phosphorylation, although no significant changes in total AKT protein levels were detected. An increased survival time was observed in an orthotopic mouse model treated with a combination of celecoxib and 5-FU compared to treatment with either agent alone.
Conclusions: Celecoxib may have an enhanced anticancer effect in combination with 5-FU. ROS production may be a key mechanisms in this combination therapy by inhibiting the AKT pathway.Introduction 1
Materials and methods 4
Cell culture 4
Chemicals 4
Cell proliferation assay 5
Production of reactive oxygen species 5
Western blot analysis 6
Orthotopic mouse model studies 7
Statistical analysis 8
Results 9
Discussion 13
References 20
Figures 28
Abstract in Korean 39Docto
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