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    Research on Entrepreneurial Characteristics of Fashion Startup Brands

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    ํ•™์œ„๋…ผ๋ฌธ (๋ฐ•์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› : ์˜๋ฅ˜ํ•™๊ณผ, 2017. 2. ์ถ”ํ˜ธ์ •.๋ณธ ์—ฐ๊ตฌ๋Š” ์ตœ๊ทผ ํ•œ๊ตญ ํŒจ์…˜ ์‹œ์žฅ์— ์‹ ๊ทœ๋กœ ์ฐฝ์—…๋œ ๋ธŒ๋žœ๋“œ ์ค‘ ๊ธฐ์—…ํ˜• ๋ธŒ๋žœ๋“œ์™€ ๋Œ€๋น„๋˜์–ด ๊ฐœ์ธ ํ˜น์€ ์†Œ์ˆ˜์˜ ์ธ๋ ฅ์— ์˜ํ•ด ์†Œ๊ทœ๋ชจ ์ž๋ณธ์œผ๋กœ ์ฐฝ์—…๋œ ๋ธŒ๋žœ๋“œ๋ฅผ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ๋กœ ์นญํ•˜๊ณ , ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์˜ ๊ตฌ์„ฑ๊ณผ, ์ฐฝ์—… ๋ฐฐ๊ฒฝ, ์œ ํ˜•๋ณ„ ๋งˆ์ผ€ํŒ… ํŠน์„ฑ์„ ๋ถ„์„ํ•˜์—ฌ ์‹ ๊ทœ๋กœ ํ˜•์„ฑ๋œ ๋ธŒ๋žœ๋“œ ์‹œ์žฅ์˜ ๊ตฌ์กฐ์— ๋Œ€ํ•œ ์ดํ•ด๋ฅผ ๋†’์ด๊ณ ์ž ํ•˜์˜€๋‹ค. ์—ฐ๊ตฌ ๋ฐฉ๋ฒ•์œผ๋กœ๋Š” ์ƒˆ๋กญ๊ฒŒ ํ˜•์„ฑ๋˜๊ณ  ์žˆ๋Š” ๋ธŒ๋žœ๋“œ ์‹œ์žฅ์— ๋Œ€ํ•œ ์ดํ•ด๋ฅผ ๋†’์ด๊ธฐ ์œ„ํ•ด ํƒ์ƒ‰์ ์ด๊ณ  ๊ท€๋‚ฉ์ ์ธ ์งˆ์  ์—ฐ๊ตฌ ๋ฐฉ๋ฒ•์„ ์‚ฌ์šฉํ•˜์˜€์œผ๋ฉฐ, ์„œ๋กœ ์ƒ์ดํ•˜๊ณ  ๋ณด์™„์ ์ธ ์ž๋ฃŒ๋กœ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ์— ๋Œ€ํ•œ ์„ค๋ช…๋ ฅ์„ ๋†’์ด๊ณ ์ž ์ฃผ์š” ํŒจ์…˜์‚ฐ์—… ์ „๋ฌธ์ง€์˜ ๋‰ด์Šค๊ธฐ์‚ฌ์— ๋Œ€ํ•œ ๋‚ด์šฉ๋ถ„์„๊ณผ ์ „๋ฌธ๊ฐ€ ๋ฐ ๋ธŒ๋žœ๋“œ ์ฐฝ์—…๊ฐ€ ๋Œ€์ƒ์˜ ์‹ฌ์ธต ๋ฉด์ ‘๋ฒ•์„ ํ•จ๊ป˜ ์‚ฌ์šฉํ•˜์˜€๋‹ค. ์—ฐ๊ตฌ ๊ฒฐ๊ณผ, ์˜จ๋ผ์ธ ์‡ผํ•‘๋ชฐ์„ ์ค‘์‹ฌ์œผ๋กœ ์ŠคํŠธ๋ฆฌํŠธ๋ธŒ๋žœ๋“œ ์‹œ์žฅ์ด ๊ธ‰์„ฑ์žฅํ•˜๋ฉฐ ๋‹ค์–‘ํ•œ ๋™๊ธฐ์™€ ์—ญ๋Ÿ‰์„ ๋ณด์œ ํ•œ ๋ธŒ๋žœ๋“œ๊ฐ€ ์‹œ์žฅ์— ๋Œ€๊ฑฐ ์ง„์ž…ํ•˜์—ฌ, ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์—๋Š” ํ˜„์žฌ ๊ทธ ํŠน์„ฑ์„ ๊ทœ์ •ํ•˜๊ธฐ ์–ด๋ ค์šธ ์ •๋„๋กœ ๋‹ค์–‘ํ•œ ํŠน์„ฑ์„ ์ง€๋‹Œ ๋ธŒ๋žœ๋“œ๋“ค์ด ํ˜ผ์žฌ๋˜์–ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ํŒŒ์•…๋˜์—ˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์—๋Š” ํ˜„์žฌ ์‹ ์ง„ ๋””์ž์ด๋„ˆ๋ธŒ๋žœ๋“œ์™€ ์ŠคํŠธ๋ฆฌํŠธ๋ธŒ๋žœ๋“œ๋ผ๋Š” ์ฃผ๋ชฉํ•  ๋งŒํ•œ ๋‘ ๊ทธ๋ฃน์˜ ๋ธŒ๋žœ๋“œ๊ฐ€ ์กด์žฌํ•˜๊ณ  ์žˆ๋Š” ๊ฒƒ์ด ๊ด€์ฐฐ๋˜์—ˆ์œผ๋ฉฐ, ๋‘ ๊ทธ๋ฃน์˜ ๋ธŒ๋žœ๋“œ๋Š” ์„œ๋กœ ๋‹ค๋ฅธ ์ฐฝ์—… ํ™˜๊ฒฝ๊ณผ ๋™๋ ฅ์— ์˜ํ•ด ํ˜•์„ฑ๋˜๊ณ  ํ™•์žฅ๋˜๊ณ  ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. ์‹ ์ง„ ๋””์ž์ด๋„ˆ๋ธŒ๋žœ๋“œ๋Š” ์ž๊ธฐ๋งŒ์˜ ๋…์ฐฝ์ ์ธ ๋””์ž์ธ ๊ธฐํš๋ ฅ์„ ์‚ฌ์—…ํ™”ํ•˜๊ณ ์ž ํ•œ ๊ธฐ์ˆ  ์ฐฝ์—…(craftsmen, technical entrepreneur) ์œ ํ˜•์œผ๋กœ ๋ณธ ์—ฐ๊ตฌ์—์„œ๋Š” ์ด๋Ÿฌํ•œ ๋ธŒ๋žœ๋“œ๋ฅผ ๋””์ž์ธ ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ๋กœ ์นญํ•˜์˜€๋‹ค. ํ•œํŽธ ์ŠคํŠธ๋ฆฌํŠธ๋ธŒ๋žœ๋“œ์—๋Š” ์‹ ๊ทœ ์œ ํ†ต ์ฑ„๋„์„ ์ค‘์‹ฌ์œผ๋กœ ์ƒˆ๋กญ๊ฒŒ ํ˜•์„ฑ๋œ ์‹œ์žฅ ๊ธฐํšŒ๋ฅผ ๋ฐœ๊ฒฌํ•œ ๊ฒƒ์ด ์šฐ์„ ์ ์ธ ์ฐฝ์—… ๋™๊ธฐ๊ฐ€ ๋œ ๊ธฐํšŒ ์ฐฝ์—…(opportunistic entrepreneur) ์œ ํ˜•์˜ ๋ธŒ๋žœ๋“œ๊ฐ€ ๋‹ค์ˆ˜ ํฌํ•จ๋˜์–ด ์žˆ์œผ๋ฉฐ, ๊ธฐํšŒ ์ฐฝ์—… ๋ธŒ๋žœ๋“œ์˜ ํŠน์„ฑ ์ƒ ์‹œ์žฅ๊ณผ ์†Œ๋น„์ž์˜ ์š”๊ตฌ์— ๋Œ€์‘ํ•˜๋Š” ๊ธฐํš๋ ฅ์ด ๊ธฐ๋ฐ˜์ด ๋˜๊ณ  ์žˆ์–ด, ๋ณธ ์—ฐ๊ตฌ์—์„œ๋Š” ์ด๋Ÿฌํ•œ ๋ธŒ๋žœ๋“œ๋ฅผ ๊ธฐํš ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ๋กœ ๊ทœ์ •ํ•˜์˜€๋‹ค. ์ดํ›„ ๋‘ ๋ธŒ๋žœ๋“œ ์œ ํ˜•์˜ ์ฐฝ์—… ๋ฐฐ๊ฒฝ๊ณผ ์„ฑ์žฅ ๋™๋ ฅ์— ๋Œ€ํ•œ ์ดํ•ด๋ฅผ ๋†’์ด๊ธฐ ์œ„ํ•ด ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์˜ ์ฐฝ์—… ๋ฐฐ๊ฒฝ์„ ๋Œ€์ƒํ™ฉ, ์†Œ์ƒํ™ฉ, ๋งค๊ฐœ์ƒํ™ฉ์œผ๋กœ ๊ตฌ๋ถ„ํ•˜๋Š” ์ƒํ™ฉ ๋ถ„์„์„ ์‹ค์‹œํ•˜์˜€๋‹ค. ๋ถ„์„ ๊ฒฐ๊ณผ, ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์˜ ์ฐฝ์—…์€ ์ฐฝ์—…๊ฐ€ ๊ฐœ์ธ์ด ๋ณด์œ ํ•˜๊ณ  ์žˆ๋˜ ์ž์•„ ์‹คํ˜„ ๋™๊ธฐ, ๊ฒฝ์ œ์  ๋™๊ธฐ, ์ง์—… ์ƒํƒœ์™€ ๊ฐ™์€ ์†Œ์ƒํ™ฉ์ด ์ฐฝ์—…์„ ์ž๊ทนํ•˜๋Š” ๊ณต๊ณต ์ง€์›, ์‹œ์žฅ ๊ธฐํšŒ์™€ ๊ฐ™์€ ๋Œ€์ƒํ™ฉ์„ ๋งŒ๋‚ฌ์„ ๋•Œ ์ด๋ฃจ์–ด์ง€๋ฉฐ, ์ด ๊ณผ์ •์— ๊ฐ€์กฑ, ์‚ฌํšŒ์  ๋„คํŠธ์›Œํฌ, ๊ต์œก, ์–ธ๋ก ๊ณผ ๊ฐ™์€ ๋งค๊ฐœ ์ƒํ™ฉ์ด ํŒจ์…˜ ์‹œ์žฅ์— ๋Œ€ํ•œ ์ธ์‹ ํ˜•์„ฑ์— ์ค‘์š”ํ•œ ์˜ํ–ฅ์„ ๋ฏธ์น˜๊ณ  ์žˆ๋Š” ๊ฒƒ์„ ๋ฐœ๊ฒฌํ•˜์˜€๋‹ค. ๋‹ค์Œ์œผ๋กœ๋Š” ๋””์ž์ธ ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์™€ ๊ธฐํš ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์˜ ๊ทธ๋ฃน๋ณ„ ๋ธŒ๋žœ๋“œ ๊ตฌ์„ฑ๊ณผ ๋งˆ์ผ€ํŒ… ํŠน์„ฑ์„ ๊ณ ์ฐฐํ•˜์˜€๋‹ค. ๋””์ž์ธ ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ๋Š” ๋ธŒ๋žœ๋“œ๊ฐ€ ํ‘œ์ ์œผ๋กœ ์‚ผ๊ณ  ์žˆ๋Š” ์„ธ๋ถ„ ์‹œ์žฅ์˜ ์‹œ์žฅ์„ฑ ์ •๋„์™€ ๋””์ž์ด๋„ˆ์˜ ์‹œ์žฅ ์ง€ํ–ฅ์  ํƒœ๋„, ํ˜น์€ ๋จธ์ฒœ๋‹ค์ด์ง• ์—ญ๋Ÿ‰์— ๋”ฐ๋ผ ์žฌ๋ฌด์  ์„ฑ๊ณผ์—์„œ ํฐ ์ฐจ์ด๋ฅผ ๋ณด์ด๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. ์„ธ๋ถ„ ์‹œ์žฅ์˜ ์‹œ์žฅ์„ฑ์ด ๋‚ฎ๊ณ  ๋Œ€์ค‘์  ์ƒํ’ˆ ๊ธฐํš์— ์–ด๋ ค์›€์„ ๊ฒช๋Š” ๊ฒฝ์šฐ ์žฌ๋ฌด์  ์„ฑ๊ณผ๊ฐ€ ๋งค์šฐ ๋‚ฎ์•˜์œผ๋ฉฐ, ๋ฐ˜๋ฉด ๋Œ€์ค‘์ ์ธ ์ƒํ’ˆ ๊ธฐํš์œผ๋กœ ๋†’์€ ์ˆ˜์ค€์˜ ์ƒ์—…์  ์„ฑ์ทจ๋ฅผ ์–ป๊ณ  ์žˆ๋Š” ๋ธŒ๋žœ๋“œ๋„ ์ƒ๋‹น ์ˆ˜ ์กด์žฌํ•˜๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. ์ŠคํŠธ๋ฆฌํŠธ ์กฐ๋‹์—์„œ ์‹œ์ž‘๋˜์–ด ์—ฌ์„ฑ๋ณต, ์žกํ™” ๋“ฑ์œผ๋กœ ํ™•์žฅ๋˜๊ณ  ์žˆ๋Š” ๊ธฐํš ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์—๋Š” ์‹œ์žฅ ๊ธฐํšŒ๋ฅผ ๋ฐœ๊ฒฌํ•œ ๋™๊ธฐ ์™ธ์— ๋‹ค์–‘ํ•œ ๋™๊ธฐ์™€ ๋ฐฐ๊ฒฝ์„ ์ง€๋‹Œ ๋ธŒ๋žœ๋“œ๊ฐ€ ํ˜ผ์žฌ๋˜์–ด ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ์ด ์ค‘ ์‹œ์žฅ์˜ ํ˜•์„ฑ์— ๊ธฐ์—ฌํ•œ ๊ธฐํšŒ ์ฐฝ์กฐ, ๊ธฐํšŒ ์ดˆ๊ธฐ ์ˆ˜์šฉ ๋ธŒ๋žœ๋“œ์™€ ์‹œ์žฅ ๊ธฐํšŒ๋ฅผ ๋ฐœ๊ฒฌํ•˜๊ณ  ์ง„์ž…ํ•œ ๊ธฐํšŒ ์ถ”์ข… ๋ธŒ๋žœ๋“œ์˜ ์ฐจ์ด์— ์ฃผ๋ชฉํ•˜์˜€๋‹ค. ๋‹ค์Œ์œผ๋กœ ๋‘ ์œ ํ˜•์˜ ๋ธŒ๋žœ๋“œ์— ๋Œ€ํ•œ ๋งˆ์ผ€ํŒ… ์ „๋žต ๋น„๊ต ๋ถ„์„์„ ์‹œํ–‰ํ•˜์˜€๋‹ค. ์ƒํ’ˆ ๊ธฐํš ์ฐจ์›์—์„œ ๋””์ž์ธ ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ๋Š” ๋ธŒ๋žœ๋“œ ์•„์ด๋ดํ‹ฐํ‹ฐ ๊ตฌ์ถ•์„ ์œ„ํ•œ ๋…์ฐฝ์„ฑ ๊ฐ•ํ•œ ์Šคํƒ€์ผ์—์„œ ๋Œ€์ค‘์ ์ธ ์Šคํƒ€์ผ ํ˜น์€ ์„ธ์ปจ ๋ธŒ๋žœ๋“œ๋กœ ํ™•์žฅํ•ด ๋‚˜๊ฐ€๋Š” ์ „๋žต์„ ์‚ฌ์šฉํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ๊ธฐํš ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ๋Š” ์ ์€ ์•„์ดํ…œ์œผ๋กœ ์ฐฝ์—…ํ•˜์—ฌ ๋ผ์ธ์—…์„ ๊ฐ–์ถฐ๊ฐ€๋Š” ๋ฐฉ์‹์œผ๋กœ ์„ฑ์žฅํ•˜๊ณ  ์žˆ๋Š” ์–‘์ƒ์ด ํƒ์ƒ‰๋˜์—ˆ๋‹ค. ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์˜ ๊ฐ€๊ฒฉ์€ ๊ธฐ์กด์˜ ์œ ๋ช… ๋‚ด์…”๋„ ๋ธŒ๋žœ๋“œ๋ณด๋‹ค๋Š” ๋‚ฎ๊ณ  SPA๋ธŒ๋žœ๋“œ์™€ ๋ฌด์ƒํ‘œ ์˜๋ฅ˜๋ณด๋‹ค๋Š” ๋†’์€ ์ง€์ ์—์„œ ํ˜•์„ฑ๋˜๊ณ  ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ์œผ๋ฉฐ, ๋Œ€๋‹ค์ˆ˜์˜ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ๊ฐ€ ์œ ์‚ฌํ•œ ๊ฐ€๊ฒฉ ํฌ์ง€์…˜์„ ๊ฐ€์ง€๊ณ  ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ํŒŒ์•…๋˜์—ˆ๋‹ค. ์œ ํ†ต ํ˜„ํ™ฉ์€ ๊ตญ๋‚ด ์˜คํ”„๋ผ์ธ ์œ ํ†ต๊ณผ ์˜จ๋ผ์ธ ์œ ํ†ต, ํ•ด์™ธ ์œ ํ†ต ์ฐจ์›์œผ๋กœ ๊ตฌ๋ถ„ํ•˜์—ฌ ๋ถ„์„ํ•˜์˜€๋‹ค. ์ด์ค‘ ์˜จ๋ผ์ธ ์œ ํ†ต ์ฑ„๋„์€ ์†Œ๋น„์ž ์ˆ˜์š”๊ฐ€ ์ฆ๊ฐ€ํ•˜๊ณ  ์˜คํ”„๋ผ์ธ ์œ ํ†ต ์ฑ„๋„ ๋Œ€๋น„ ์ง„์ž… ์žฅ๋ฒฝ์ด ๋‚ฎ๊ณ  ์ˆ˜์ต์„ฑ์ด ๋†’์•„ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์—๊ฒŒ ํšจ๊ณผ์ ์ธ ์œ ํ†ต ์ฑ„๋„์ด ๋˜๊ณ  ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. SNS์™€ ๊ฐ™์€ ์˜จ๋ผ์ธ ์ฑ„๋„์ด ํšจ๊ณผ์ ์ธ ํ™๋ณด ์ฑ„๋„๋กœ ์ž๋ฆฌ๋งค๊น€๋˜์–ด, SNS ์†Œํ†ต์— ๊ฐ•์ ์„ ๋ณด์œ ํ•œ ๋ธŒ๋žœ๋“œ๊ฐ€ ์„ฑ๊ณต ๊ธฐํšŒ๋ฅผ ์–ป๊ณ  ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. ํ•œํŽธ, ๋‘ ๊ทธ๋ฃน์˜ ๋ธŒ๋žœ๋“œ๋“ค์ด ๊ฒฝ์Ÿ์„ ํ†ตํ•ด ๊ธฐํš๊ณผ ๋””์ž์ธ์„ ๊ฐ•ํ™”ํ•จ์œผ๋กœ์จ ๋‘ ๊ทธ๋ฃน ๊ฐ„์˜ ๊ฒฝ๊ณ„๊ฐ€ ๋ถˆ๋ถ„๋ช…ํ•ด์ง€๊ณ  ์žˆ๋Š” ํ˜„์ƒ์ด ์ฃผ๋ชฉํ•  ๋งŒ ํ•˜์˜€๋‹ค. ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์˜ ๋ธŒ๋žœ๋“œ ๊ฒฝ์˜์— ๋Œ€ํ•œ ๋ถ„์„ ๊ฒฐ๊ณผ, ์„ ํ–‰ ์—ฐ๊ตฌ๊ฐ€ ์ œ์‹œํ•œ ์†Œ๊ทœ๋ชจ ์ฐฝ์—… ๋ธŒ๋žœ๋“œ์˜ ๊ฒฝ์˜ ์žฅ์•  ์š”์ธ๊ณผ์˜ ์ฐจ์ด์ ์ด ๋ฐœ๊ฒฌ๋˜์—ˆ๋‹ค. ๋ธŒ๋žœ๋“œ ์šด์˜ ์ „๋ฐ˜์—์„œ ์˜์„ธํ•œ ๊ทœ๋ชจ๋กœ ์ธํ•œ ๋ถˆ๋ฆฌํ•จ์ด ์กด์žฌํ•˜์ง€๋งŒ ๋ธŒ๋žœ๋“œ ์šด์˜ ์ƒ ํฌ๊ฒŒ ๋ฌธ์ œ๊ฐ€ ๋˜์ง€๋Š” ์•Š๋Š”๋‹ค๋Š” ์˜๊ฒฌ์ด ๋‹ค์ˆ˜ ๋ณด๊ณ ๋˜์—ˆ๋Š”๋ฐ, ์ด๋Ÿฌํ•œ ์ด์œ ๋กœ ์ฒซ์งธ, ๋ธŒ๋žœ๋“œ ์ฐฝ์—… ์‹œ ์œ ํ†ต๊ณผ ํ™๋ณด ์ฐจ์›์˜ ์ง„์ž… ์žฅ๋ฒฝ์ด ํฌ๊ฒŒ ๋‚ฎ์•„์ง„ ๊ฒƒ์ด ์†Œ๊ทœ๋ชจ์˜ ๋ถˆ๋ฆฌํ•จ์„ ๊ฒฝ๊ฐ์‹œํ‚ค๋Š” ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. ๋‘˜์งธ, ์ž๋ณธ ๋™์› ๋Šฅ๋ ฅ ์ฐจ์›์—์„œ ์˜จ๋ผ์ธ ์‡ผํ•‘ ํ™˜๊ฒฝ์ด ์†Œ์ž๋ณธ ๋ธŒ๋žœ๋“œ์— ์นœํ™”์ ์ธ ํ™˜๊ฒฝ์„ ์ œ๊ณตํ•˜๊ณ  ์žˆ์œผ๋ฉฐ, ์ž๋ณธ ๋™์› ๋ฐฉ์‹์—์„œ๋„ ํˆฌ์ž ์œ ์น˜๋ฐฉ๋ฒ•์ด ๋‹ค์–‘ํ™”๋˜๊ณ  ์žˆ์–ด ์ž๋ณธ ์ง„์ž… ์žฅ๋ฒฝ ๋˜ํ•œ ๋‚ฎ์•„์ง„ ๋ชจ์Šต์„ ๋ณด์˜€๋‹ค. ๋”ฐ๋ผ์„œ ์†Œ๊ทœ๋ชจ ์ฐฝ์—… ๋ธŒ๋žœ๋“œ์—๊ฒŒ ์–ด๋ ค์šด ์ ์œผ๋กœ ๊ผฝํžˆ๋˜ ์š”์ธ๋“ค์ด ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์—๊ฒŒ๋Š” ์•ฝํ™”๋˜๊ฑฐ๋‚˜ ํฐ ์˜ํ–ฅ์„ ๋ฏธ์น˜์ง€ ์•Š๋Š” ๋ฐฉํ–ฅ์œผ๋กœ ์‹œ์žฅ ํ™˜๊ฒฝ์ด ๋ณ€ํ™”๋œ ๊ฒƒ์œผ๋กœ ๋ถ„์„๋˜์—ˆ๋‹ค. ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ ์‹œ์žฅ์€ ํ˜•์„ฑ ์ดˆ๊ธฐ์— ๋‹จ์ˆœํ•˜๋˜ ๊ตฌ์กฐ๊ฐ€ ํ™˜๊ฒฝ ๋ณ€ํ™”์™€ ๋ธŒ๋žœ๋“œ๊ฐ„ ๊ฒฝ์Ÿ์ด ์‹ฌํ™”๋˜๋ฉฐ ๋”์šฑ ๋ณต์žกํ•ด์ง€๊ณ  ์„ธ๋ถ„ํ™”๋˜๋Š” ๊ฒฝํ–ฅ์„ ๋ณด์ด๊ณ  ์žˆ๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” 2009๋…„ ์ดํ›„ ํ•œ๊ตญ ํŒจ์…˜ ์‹œ์žฅ์—์„œ ๊ฐ€์‹œํ™”๋œ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ๋ฅผ ์—ฐ๊ตฌ๋Œ€์ƒ์œผ๋กœ, ๊ธฐ์ˆ  ์ฐฝ์—…์  ํŠน์„ฑ์„ ๋ณด์ด๋Š” ๋””์ž์ธ ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์™€ ๊ธฐํšŒ ์ฐฝ์—…์  ํŠน์„ฑ์„ ๋ณด์ด๋Š” ๊ธฐํš ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ ๋‘ ์œ ํ˜•์˜ ์œ ํ˜•๋ณ„ ํŠน์„ฑ๊ณผ ๋งˆ์ผ€ํŒ… ํŠน์„ฑ์„ ๋ถ„์„ํ•˜์—ฌ ํŒจ์…˜ ๋ธŒ๋žœ๋“œ์˜ ๊ฒฝ์Ÿ๊ณผ ์„ฑ์žฅ์„ ์ดํ•ดํ•˜๋Š”๋ฐ ๊ธฐ์—ฌํ•˜๊ณ ์ž ํ•˜์˜€๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ ๋‘ ์œ ํ˜•์˜ ์ฐฝ์—… ์ƒํ™ฉ์— ๋Œ€ํ•œ ๋น„๊ต ๋ถ„์„์„ ํ†ตํ•ด, ํŒจ์…˜ ๋ธŒ๋žœ๋“œ์˜ ์„ฑ์žฅ์—๋Š” ์†Œ๋น„์ž์˜ ์š”๊ตฌ์™€ ์‹œ์žฅ์„ฑ์— ๋Œ€ํ•œ ๋ถ„์„์ด ํ•„์ˆ˜์ ์ด๋ฏ€๋กœ ์‹ ๊ทœ ๋ธŒ๋žœ๋“œ ์ฐฝ์—… ์‹œ ์‹œ์žฅ์— ๋Œ€ํ•œ ๊ท ํ˜• ์žกํžŒ ์‹œ๊ฐ์„ ํ™•๋ณดํ•˜๊ณ  ์‹œ์žฅ ์ง€ํ–ฅ์  ํƒœ๋„ ๋ฐ ๋จธ์ฒœ๋‹ค์ด์ง• ์—ญ๋Ÿ‰์„ ๊ฐ•ํ™”ํ•˜๋Š” ๊ฒƒ์ด ์ค‘์š”ํ•˜๋‹ค๋Š” ์ ์„ ์ œ์•ˆํ•˜์˜€๋‹ค. ์ด๋Ÿฌํ•œ ์ œ์•ˆ์€ ์ฐฝ์—… ์ค€๋น„ ๋‹จ๊ณ„ ํ˜น์€ ์ดˆ๊ธฐ ๋‹จ๊ณ„ ๋ธŒ๋žœ๋“œ์—๊ฒŒ ์‹ค๋ฌด์  ์‹œ์‚ฌ์ ์„ ์ œ๊ณตํ•  ์ˆ˜ ์žˆ์„ ๊ฒƒ์ด๋‹ค. ๋ณธ ์—ฐ๊ตฌ๋Š” ์งˆ์  ์—ฐ๊ตฌ๋ฅผ ๊ธฐ๋ฐ˜์œผ๋กœ ํ•˜์—ฌ ์ ‘๊ทผ๋ฒ•์ด ๋ฐœ๊ฒฌ์ ์ด๋‹ค. ๋”ฐ๋ผ์„œ ๋ณธ ์—ฐ๊ตฌ์—์„œ ๋ฐœ๊ฒฌ์ด ๋ฏธ์ง„ํ•œ ์˜์—ญ์— ๋Œ€ํ•œ ์ถ”๊ฐ€์ ์ธ ์‚ฌ๋ก€ ์—ฐ๊ตฌ๊ฐ€ ํ•„์š”ํ•  ๊ฒƒ์œผ๋กœ ์ƒ๊ฐ๋˜๋ฉฐ, ๋ณธ ์—ฐ๊ตฌ์—์„œ ์ค‘์š”ํ•˜๊ฒŒ ํƒ์ƒ‰๋œ ์ฐฝ์—… ํ™˜๊ฒฝ ๋ฐ ์„ฑ๊ณผ ์˜ํ–ฅ ์š”์ธ์— ๋Œ€ํ•œ ์‹ค์ฆ ์—ฐ๊ตฌ๋„ ํ•„์š”ํ•  ๊ฒƒ์œผ๋กœ ํŒ๋‹จ๋œ๋‹ค.์ œ 1 ์žฅ ์„œ ๋ก  1 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ์˜ ๋ฐฐ๊ฒฝ ๋ฐ ํ•„์š”์„ฑ 1 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ์˜ ๋ชฉ์  ๋ฐ ๋ฐฉ๋ฒ• 4 ์ œ 2 ์žฅ ์ด๋ก ์  ๋ฐฐ๊ฒฝ 5 ์ œ 1 ์ ˆ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ 5 1. ์Šคํƒ€ํŠธ์—… 5 2. ํŒจ์…˜ ๋ธŒ๋žœ๋“œ์˜ ์œ ํ˜• 6 3. ๋””์ž์ด๋„ˆ๋ธŒ๋žœ๋“œ 9 ์ œ 2 ์ ˆ ์ฐฝ์—…๊ณผ ์ฐฝ์—… ์œ ํ˜• 22 1. ์ฐฝ์—… ๊ด€๋ จ ์„ ํ–‰ ์—ฐ๊ตฌ 22 2. ์ฐฝ์—…์˜ ์œ ํ˜• 25 ์ œ 3 ์ ˆ ์ฐฝ์—… ํ™˜๊ฒฝ 31 1. ๊ฐœ์ธ ํ™˜๊ฒฝ 31 2. ์™ธ๋ถ€ ํ™˜๊ฒฝ 38 ์ œ 3 ์žฅ ์—ฐ๊ตฌ ๋ฌธ์ œ ๋ฐ ์—ฐ๊ตฌ ๋ฐฉ๋ฒ• 44 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ ๋ฌธ์ œ 44 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ ๋ฐฉ๋ฒ• ๋ฐ ์ ˆ์ฐจ 46 1. ์—ฐ๊ตฌ ๋ฐฉ๋ฒ•๊ณผ ์—ฐ๊ตฌ ์„ค๊ณ„ 46 2. ๋‰ด์Šค๊ธฐ์‚ฌ ๋‚ด์šฉ๋ถ„์„ 47 3. ์ „๋ฌธ๊ฐ€ ๋ฐ ์ฐฝ์—…๊ฐ€ ๋Œ€์ƒ ์งˆ์ ์—ฐ๊ตฌ 49 4. ์ž๋ฃŒ์˜ ํŠน์„ฑ 55 ์ œ 4 ์žฅ ์—ฐ๊ตฌ ๊ฒฐ๊ณผ 56 ์ œ 1 ์ ˆ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ 56 1. ํŒจ์…˜ ์‹œ์žฅ ๋‚ด ์—ญํ• ๊ณผ ์˜์˜ 56 2. ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์˜ ๊ตฌ์„ฑ 65 ์ œ 2 ์ ˆ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ ์ฐฝ์—…์˜ ์ƒํ™ฉ์  ๊ตฌ์กฐ 78 1. ๋””์ž์ธ ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์˜ ์ฐฝ์—… ์ƒํ™ฉ 78 2. ๊ธฐํš ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์˜ ์ฐฝ์—… ์ƒํ™ฉ 90 ์ œ 3 ์ ˆ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ์˜ ์œ ํ˜•๋ณ„ ํŠน์„ฑ 99 1. ๋””์ž์ธ ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์˜ ํŠน์„ฑ 99 2. ๊ธฐํš ์ค‘์‹ฌ ๋ธŒ๋žœ๋“œ์˜ ํŠน์„ฑ 117 ์ œ 4 ์ ˆ ํŒจ์…˜ ์Šคํƒ€ํŠธ์—… ๋ธŒ๋žœ๋“œ ์ฐฝ์—… ์‚ฌ๋ก€ 130 1. ์—˜๋ฆฌํŠธ ๋””์ž์ด๋„ˆ JS 130 2. ์†Œ๋ฐ•ํ•œ ์˜ˆ์ˆ ๊ฐ€ ๋””์ž์ด๋„ˆ PD 135 3. ๋…ผ์‹œ์ฆŒ ๋ธŒ๋žœ๋“œ BA 140 4. ๋””์ž์ธ ์žกํ™” ๋ธŒ๋žœ๋“œ R 143 5. ์ŠคํŠธ๋ฆฌํŠธ๋ธŒ๋žœ๋“œ S 149 6. ํ•˜์ด์—”๋“œ ์ŠคํŠธ๋ฆฌํŠธ๋ธŒ๋žœ๋“œ U 154 ์ œ 5 ์žฅ ๊ฒฐ๋ก  159 ์ œ 1 ์ ˆ ์—ฐ๊ตฌ์˜ ์š”์•ฝ ๋ฐ ๊ฒฐ๋ก  159 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ์˜ ์‹œ์‚ฌ์  164 ์ œ 3 ์ ˆ ์—ฐ๊ตฌ์˜ ์ œํ•œ์  ๋ฐ ํ›„์† ์—ฐ๊ตฌ๋ฅผ ์œ„ํ•œ ์ œ์–ธ 166 ์ฐธ๊ณ ๋ฌธํ—Œ 168Docto

    Resveratrol regulates CXCR4 expression and downstream signaling of Caki-1 cells in vivo and in vitro

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    Dept. of Medicine/์„์‚ฌ[ํ•œ๊ธ€] [์˜๋ฌธ] Resveratrol, a phytoestrogen found in food products such as grapes and wine, produces various physiological effects. Resveratrol possesses anticancer activity: it inhibits proliferation and induces apoptotic cell death in multiple cancers cells. The chemokine stromal cell-derived factor-1ฮฑ (SDF-1ฮฑ)/CXCR4 axis plays a prominent role in tumorigenesis and promotes angiogenesis and migration of tumor cells to metastatic sites in many cancers. Expression of CXCR4 was shown to be upregulated in most renal cell carcinoma (RCC) patients. In human RCC, CXCR4 plays a major role in the proliferation and growth of cancer cells through activation of PI3K/AKT signaling. We demonstrate that resveratrol suppresses the expression of CXCR4, and inhibits cell proliferation and growth of the human kidney cancer cell line, Caki-1. We show that resveratrol suppresses RNA and protein expression of CXCR4 in Caki-1 cells by a mechanism involving transcriptional regulation. Recombinant SDF-1ฮฑ, the ligand of CXCR4, induces cell proliferation and AKT and extracellular signal?regulated kinase(ERK) 1/2 activation, and can, independently, cause renal cell carcinoma cells proliferation. Resveratrol inhibits cell growth and proliferation caused by SDF-1ฮฑ in Caki-1 cells. Also, we examined the therapeutic efficacy of resveratrol in vivo by treating SCID mice bearing Caki-1 cells. Resveratrol suppressed both tumor growth and the expression of CXCR4 in the xenograft model. These data suggest that resveratrol may be a therapeutic agent for kidney cancer as an effective inhibitor of CXCR4. These results may provide a new therapeutic strategy for the use of a natural compound in the treatment of human kidney cancer.ope

    (The) age of acquisition effect reading Korean : an eye tracking study

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ) --์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :ํ˜‘๋™๊ณผ์ • ์ธ์ง€๊ณผํ•™์ „๊ณต,2009.8.Maste

    ๋ฏธ์•”์ผ๊ธฐ(็œ‰ๅท–ๆ—ฅ่จ˜)๋ฅผ ํ†ตํ•ด ๋ณธ 16์„ธ๊ธฐ ์‚ฌ๋Œ€๋ถ€ ๋ณต์‹

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :์˜๋ฅ˜ํ•™๊ณผ,2006.Maste

    current pharmacologic thwrapy of osteoporosis

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    ํ•™์œ„๋…ผ๋ฌธ (์„์‚ฌ)-- ์„œ์šธ๋Œ€ํ•™๊ต ์น˜์˜ํ•™๋Œ€ํ•™์› : ์น˜์˜ํ•™๊ณผ, 2014. 2. ์ด์žฅํฌ.๊ณจ๋‹ค๊ณต์ฆ์€ ๊ณจ๋ฐ€๋„๊ฐ€ ๊ฐ์†Œํ•˜๊ณ  ๊ณจ ๋ฏธ์„ธ ๊ตฌ์กฐ์— ์ด์ƒ์ด ์ƒ๊ธฐ๋Š” ๋งŒ์„ฑ ์งˆํ™˜์ด๋‹ค. ๊ณจ๋‹ค๊ณต์ฆ์— ์˜ํ•œ ์ฒ™์ถ”, ์†๋ชฉ, ๊ณจ๋ฐ˜ ๊ณจ์ ˆ์— ์˜ํ•œ ์‹ ์ฒด์ , ๊ฒฝ์ œ์  ์†์‹ค์€ ๊ฐœ์ธ๊ณผ ๊ตญ๊ฐ€์ ์œผ๋กœ ํฐ ์†์‹ค์ด ๋˜๊ณ  ์žˆ๋‹ค. ๊ณจ๋‹ค๊ณต์ฆ ํ™˜์ž์˜ ์ฆ๊ฐ€์— ๋”ฐ๋ผ ํ˜„์žฌ ๋งŽ์€ ๊ณจ๋‹ค๊ณต์ฆ ์น˜๋ฃŒ ์•ฝ์ œ๊ฐ€ ์ด๋ฏธ ๊ฐœ๋ฐœ๋˜์—ˆ์ง€๋งŒ ์žฅ๊ธฐ์น˜๋ฃŒ์— ๋”ฐ๋ฅด๋Š” ๋ถ€์ž‘์šฉ๋„ ์–ธ๊ธ‰๋˜๊ณ  ์žˆ์–ด์„œ ํ˜„์žฌ ์น˜๋ฃŒ์ง€์นจ์˜ ๋ณ€ํ™”์— ๋Œ€ํ•œ ๋…ผ์˜๊ฐ€ ์ง„ํ–‰ ์ค‘์œผ๋กœ ์•Œ๋ ค์ ธ ์žˆ๋‹ค. ์ตœ๊ทผ์˜ ์—ฐ๊ตฌ์—์„œ ๊ณจ๊ธฐ์งˆ ๋‹จ๋ฐฑ์งˆ์ด ๊ทธ ๊ตฌ์„ฑ์„ฑ๋ถ„์ผ ๋ฟ๋งŒ ์•„๋‹ˆ๋ผ ๊ณจ๋Œ€์‚ฌ ์กฐ์ ˆ์— ๊ด€์—ฌํ•˜๊ณ  ์žˆ์œผ๋ฉฐ ๊ณจ๊ธฐ์งˆ์— ํ’๋ถ€ํ•˜๊ฒŒ ์กด์žฌํ•˜๋Š” ๋งŽ์€ ์„ฑ์žฅ์ธ์ž์™€ ํ˜ธ๋ฅด๋ชฌ, ์‹ ํ˜ธ์ „๋‹ฌ ๋ฌผ์งˆ๋“ค๋„ ๊ณจ๋Œ€์‚ฌ์— ์ค‘์š”ํ•œ ์—ญํ• ์„ ๋‹ด๋‹น ํ•œ๋‹ค. ๊ณจ๋‹ค๊ณต์ฆ ์น˜๋ฃŒ์ œ๋Š” ๊ณจ ํ˜•์„ฑ ์ด‰์ง„์ œ์™€ ๊ณจ ํก์ˆ˜ ์–ต์ œ์ œ๋กœ ๋ณดํ†ต ๋‚˜๋ˆˆ๋‹ค. ๊ณจ ํก์ˆ˜ ์–ต์ œ์ œ๋Š” ๋ผˆ๋กœ๋ถ€ํ„ฐ ๋ฐฉ์ถœ๋œ ์นผ์Š˜์˜ ํ˜ˆ์ค‘ ๋†๋„๋ฅผ ๋‚ฎ์ถ”๊ณ  ๋‡จ๋กœ ๋ฐฐ์„ค๋˜๋Š” ์–‘๋„ ๊ฐ์†Œ์‹œํ‚จ๋‹ค. ์ด ์•ฝ์ œ๋Š” ๊ณจ ํก์ˆ˜๋ฅผ ์–ต์ œํ•˜๋Š” ๊ฒƒ์ด ์ฃผ๋œ ๊ธฐ์ „์ด๋ฏ€๋กœ ์ด๋ก ์ ์œผ๋กœ๋Š” ๊ณจ ์–‘์˜ ์ฆ๊ฐ€๋ฅผ ๊ธฐ๋Œ€ํ•˜๊ธฐ ์–ด๋ ต์ง€๋งŒ ์‹ค์ œ๋กœ๋Š” ์†Œ๋Ÿ‰์˜ ๊ณจ ์–‘์˜ ์ฆ๊ฐ€๋ฅผ ๊ด€์ฐฐํ•  ์ˆ˜ ์žˆ๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ๊ณจ ํก์ˆ˜ ์–ต์ œ์ œ ํˆฌ์—ฌ์— ์˜ํ•˜์—ฌ ์–ป์„ ์ˆ˜ ์žˆ๋Š” 6~8%์˜ ๊ณจ ๋ฐ€๋„์ฆ๊ฐ€ ์ด์ƒ์˜ ๊ฒฐ๊ณผ๋ฅผ ์–ป๊ธฐ ์œ„ํ•ด์„œ๋Š” ๊ณจ ํ˜•์„ฑ ์ด‰์ง„์ œ๊ฐ€ ํ•„์š”ํ•˜๋‹ค. ๊ณจ๋‹ค๊ณต์ฆ ์น˜๋ฃŒ์•ฝ์ œ์— ๋Œ€ํ•œ ๋ฐ˜์‘์€ ๊ฐœ์ธ๋งˆ๋‹ค ๋‹ค๋ฅด๋ฉฐ, ๊ณจ๊ฒฉ ๋ถ€์œ„์— ๋”ฐ๋ผ์„œ๋„ ๋‹ค๋ฅผ ์ˆ˜ ์žˆ๋‹ค. ์–ด๋–ค ๊ธฐ์ „์ด๋“ ์ง€ ์ด์ƒ์ ์ธ ๊ณจ๋‹ค๊ณต์ฆ ์น˜๋ฃŒ ์•ฝ์ œ๋Š” ๊ณจ ๋ฐ€๋„๋ฅผ ๊ณจ์ ˆ ๋ฐœ์ƒ์น˜ ์ด์ƒ์œผ๋กœ ์œ ์ง€, ์ฆ๊ฐ€์‹œํ‚ค๊ณ  ๊ณจ ๊ตฌ์กฐ๋ฅผ ํšŒ๋ณต์‹œ์ผœ ๊ณจ์ ˆ์„ ๊ฐ์†Œ์‹œํ‚ค๋Š” ๊ฒƒ์ด๋‹ค. ๊ทธ๋Ÿฌ๋‚˜ ํ˜„์žฌ๊นŒ์ง€ ๋งŽ์€ ์—ฐ๊ตฌ์—๋„ ๋ถˆ๊ตฌํ•˜๊ณ  ๋ถ€์ž‘์šฉ์—†์ด ๊ณจ ๋ฐ€๋„๋ฅผ ์ฆ๊ฐ€์‹œํ‚ค๋ฉฐ ๊ณจ์ ˆ ๋นˆ๋„๋ฅผ ๋‚ฎ์ถ”๋Š” ์•ฝ์ œ๊ฐ€ ๊ฐœ๋ฐœ๋˜์–ด ์žˆ์ง€ ์•Š์œผ๋ฏ€๋กœ ๋น ๋ฅธ ์‹œ๊ธฐ์— ์ง„๋‹จํ•˜์—ฌ ๊ณจ๋‹ค๊ณต์ฆ์„ ์˜ˆ๋ฐฉํ•˜๋Š” ๊ฒƒ์ด ์ตœ์„ ์˜ ์น˜๋ฃŒ๋กœ ์—ฌ๊ฒจ์ง„๋‹ค, ๊ณจ๋‹ค๊ณต์ฆ์— ๋Œ€ํ•œ ์น˜๋ฃŒ๋Š” ๊ณ„์† ์—ฐ๊ตฌ๋  ์ „๋ง์ด๋‹ค.์ œ 1 ์žฅ ์„œ ๋ก  1 ์ œ 1 ์ ˆ ๊ณจ๋‹ค๊ณต์ฆ 1 ์ œ 2 ์ ˆ ์—ฐ๊ตฌ์˜ ๋‚ด์šฉ 2 ์ œ 2 ์žฅ ๋ณธ ๋ก  3 ์ œ 1 ์ ˆ ๊ณจ๋‹ค๊ณต์ฆ ์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ ์—ฐ๊ตฌ 3 ์ œ 2 ์ ˆ ๊ณจ๋‹ค๊ณต์ฆ์˜ ์น˜๋ฃŒ์ œ(๊ณจํก์ˆ˜์–ต์ œ์ œ) 8 ์ œ 3 ์ ˆ ๊ณจ๋‹ค๊ณต์ฆ์˜ ์น˜๋ฃŒ์ œ(๊ณจํ˜•์„ฑ์ด‰์ง„์ œ) 26 ์ œ 3 ์žฅ ๊ฒฐ ๋ก  35 ์ฐธ๊ณ ๋ฌธํ—Œ 38Maste

    Lipid raft cholesterol and genistein inhibit the cell viability of prostate cancer cells via the partial contribution of EGFR-Akt/p70S6k pathway and down-regulation of androgen receptor.

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    Soy isoflavones and cholesterol have been reported as dietary factors related to the incidence of prostate cancer. In this study, we investigated whether cell survival could be suppressed by a combination of the dispersion of lipid raft microdomains and treatment with genistein, a well-known potential isoflavone, in LNCaP prostate cancer cells. Cell viability was assayed by the property of reagent change upon reduction of resazurin to resorufin and apoptosis was evaluated by ethidium bromide/acridine orange (EB/AO) staining and PARP and caspase-3 expression. Signal transduction was investigated by immunoblot analysis. Cell viability decreased significantly more following successive double treatment with genistein and the cholesterol-lowering agent 2-hydroxypropyl-beta-cyclodextrin (HPCD) than in response to either agent alone. Apoptotic cell staining and cleavage of PARP and caspase-3 appeared more clearly in double-treated cells than in those treated with genistein alone. In cell signaling, both HPCD and genistein decreased the protein expressions of pAkt as well as the androgen receptors stimulated by EGF and DHT, respectively, in concentration-dependent manners. This pattern was also present in protein levels of pAkt and the androgen receptor located in the lipid raft fraction. Furthermore, the phosphorylation cascade of Akt, GSK-3beta and p70S6k was markedly inhibited by the combination treatment. These data suggest that prostate cancer cells could be effectively inhibited by combination treatment of cholesterol-lowering strategies and genistein. The mechanism is likely to be partially via both the EGFR-mediated Akt or p70S6k pathways and a down-regulation of androgen receptor in the lipid raft microdomainope
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