A pathologic study on the ovarian tumors

A total of 726 cases of ovarian tumor was obtained from the pathology file of the Department of Pathology, College of Medicine, Seoul National University during a period of 13 years beginning from January 1968 to December 1980. These tumors consisted of 605 cases (83. %) of benign tumors and 121 cases 06.7%) of malignant tumors. Metastatic carcinoma was the most frequent malignant tumor (24.0%), followed by mucinous borderline tumor Cl7.4%), serous carcinoma (9.996), and serous borderline tumor (9.1%). Among germ-cell malignancies dysgerminoma was the most frequent tumor (4.1%), followed by mature cystic teratoma with malignant transformation (3.3 %), endodermal sinus tumor (2.5%). Mature cystic teratoma was the most frequent benign tumor (24.096), followed by serous cystadenoma and adenofibroma (25.1%), mucinous cystadenoma and adenofibroma (22.196), and fibromata. 5%). Benign tumors were most prevalent during the reproductive period, but malignant tumors were prevalent in older age group, particular after the age of 40; malignant tumor of germ cell origin such as dysgerminoma. endodermal sinus tumor, and immature teratoma was prevalent in the 1st and 2nd decade of life. Bilateral involvement was most frequent in metastatic carcinoma (69.2%) followed by serous carcinoma (54.596), cystic teratoma Cl2.8%), and serous cystadenoma ClO.8%). The chief complaints of ovarian tumor patients were abdominal pain, palpable abdominal mass, and menstrual abnormality. Duration of symptoms prior to admission was longer in benign tumor than in malignant tumors. There were very rare tumors, which were not in record in Korean literature. They were 1 case of sclerosing stromal tumor, 1 case of insular carcinoid primary in the ovary, 1 case of juvenlie granulosa cell tumor, and 2 cases of gonadoblastorna with dysgerminoma. Detailed descriptions were given on these rare tumors. In summary germ cell tumors were relatively frequent in Korea than western country. This may be explained by a lower incidence of common epithelial tumor

Effect of Thymectomy on Immunological Function in Adult Mice

Adult thy mectomy in combination with or without whole body irradiation was performed in C,H mice and attempts were made to test the hypothesis that presence of the thymus is necessary for recovery of immune reactivity in adult life. Adult thymectomy didnt induce significant increase in incidence of wasting and mortality rate as well as significant decrease in immune reactivity to transp· lanted liposarcoma. Whole-body irradiation in combination with thymeetomy induced apparently more increase in incidence of wasting and mortality rate as well as much more decrease in peripheral lymphocytes/granulocyte ratio and numbers of LPC in deep cortical area of regional lymph node and periarteriallymphatic sheath of spleen in relation to transplantation of liposarcoma than non-operated group. These observations indicate that thymus is necessary in recovery of immune reactivity in adult life by means of increase in adequate pool of immunologically competent cells

Angiolymphoid hyperplasia with eosinophilia (Kimuras disease)

Observations on seven cases of angiolymphoid hyperplasia with eosinophilia (Kimuras disease) are presented. The lesion occurred most frequently in the second decade of life with the mean age of 28. 7 years. The chief complaints were mass or swelling in the neck, submandibular area or cheek for the average period of 4 years. In 4 of 7 patients the lesions were multiple. The lesions range from O. 7~ Bern in diameter and in 5 of 7 patients they measured 3cm or more in diameter. Of the 6 men and 1 woman involved, 5 showed involvement of subcutaneous adipose tissue and 2 showed involvement of both dermis and subcutaneous adipose tissue. The lesion extended into adjacent skeletal muscle (2 cases) and salivary gland (4 cases). Apart from blood eosi nophilia there were no systemic manifestations. The characteristic histopathological features were mild to moderate vascular proliferation, moderate to marked lymphoid infiltration, moderate to heavy eosinophilic infiltration and lymphoid follicles with germinal centers. In the early lesion vascular proliferation was prominent but in the later period lymphoid infiltration with lymphoid follicles was the main feature. All three cases recurred after excision of the lesion but in 1 of 2 cases the mass disappeared after admin istration of prednisone, suggesting benificial effect of prednisone These clinicopathologic features suggest that angiolymphoid hyperplasia with eosinophilia (Kimuras disease) is a distinct clinicopathological entity. Its clinicopathologic differences among different geographic areas and races and differential diagnoses are discusse

Bifida Sternum (An ButopSy case of complete type)

An autopsy case of bifid sternum in a male deadborn fetus after 22 weeks of gestation in a 25 year old mother is described. The sternum was split with the maximum distance of 3cm, and was extending from manubrium all the way down to the xyphoid process. This defect was made of thin fibrous membrane under which normally located heart was found with its intact pericardium. Rib attachment to the sternum was normally made and both clavicles were also normally formed and connected. This patient also had cleft lip and palate, flexion deformity of both hands, ventricular septal defect and horseshoe kidney

Postradiation extraskeletaI osteosarcoma after treatment of hemangioma of bone

A case of postradiation extraskeletal osteosarcoma, first case in Korea, is reported. This tumor arose in the soft tissue of left hip just above the greater trochanter that 4 years and 10 months previously had 'received 6,000 rad of radiation over a period of 6 weeks after removal of hemangioma of left ilium. Pathologically the tumor was a pleomorphic spindle cell tumor with multifocal osteoid deposition, which is indistingushable from conventional osteosarcoma of bone microscopially, Histogenesis of this tumor is discussed

A Histopathologic Study on Primary Tumors of Bone

A total of 182 cases of primary tumors of bone and cartilage was obtained from the Pathology file of the Department of Pathology, College of Medicine, Seoul National University during a period of 10 years beginning from January 1968 to December 1977. These tumors consisted of 85 cases(47%) of benign tumors and 97 cases(53%) of malignant tumors. Osteo· chondroma was most frequent benign tumor(38. 8%) , followed by giant cell tumor(22.9%) , chondroma (12. 9%) , and osteoid osteoma(9. 4%). Osteosarcoma was the most frequent malignant tumor(49.5%) , followed by myeloma (19. 6%), chondrosarcoma (10.3 %), Ewings tumor(7. 2%) , and fibrosarcoma(7. 2%). Benign tumors were most prevalent in the 2nd and 3rd decade (71. 1%). Osteosarcoma and Ewings tumor were frequent in 2nd decade but chondrosarcoma, myeloma , parosteal osteosarcoma, and chordoma were primarily tumors of adulthood after 40 years of age The long tubular bones including femur and tibia were the site of predilection of benign tumors and osteosarcoma. But enchondroma characteristically involved phalangeal bones of hand. Chondrosarcoma had predilection for innominate bone, sacrum and femur. The chief complaints of bone tumor patient were palpable mass and/ or pain. The duration of symptoms prior to admission was longer in benign tumors in contrast to shorter history in malignant tumors. but a history of 5 years or longer was not unusual in chondrosarcoma and parosteal osteosarcom

Heteropagus(An autopsy case)

Heteropagus is unequal and asymmetrical conjoined twins, one component of which is smaller than and dependent on the other. It consists of two members of very unequal degrees of development, the one (autosite) being normal or nearly so and the other (parasite) being incomplete. It is attached to the first as a dependent growth, usually attached to some point on the ventral surface. This twins were delivered to a 30 year old mother after 23 weeks of gestation. The twins were joined on anterolateral chest. The one (autosite) was grossly normal, while the other (parasite) was smaller. At the autopsy, the twins weighed 202gm, and were 22. Scm and 8. Scm in crown-heel lengths each. The autosite was grossly normal. The parasite had poorly developed cystic head portion, two arms and two legs. One umbilical cord was attached to the lower conjoined site. Between autosite and parasite, the internal organs had no connection. In autosite, the anomalies of the heart and great vessels were complete transposition of the great vessels, atrial septal defect, ventricular septal defect and incomplete development of tbe left ventricle. In parasite the head portion had no brain parenchyme and skull bone. There was vestigial epiglottis and larynx seen in this cavity. The heart anomalies consisted of common ventricle and atrial septal defect. The aortic branch draining head portion was poorly developed but the right lung was incompletely bilobed. In abdominal cavity, there were two spleens of almost same size. On serial sections of umbilical cord, there were one vein and four arteries. One vein and 1wo arteries drained into the autosite while the other two arteries iinto the parasite. This case is the second example of polysplenia 'seen in conjoined twins in is Department. And -combined anomalies seen in both parasite and autosite were of interest in terms of their pathogenesis and relationship to the heterotaxia

Desmoplastic Fibroma of Bone -Repor t of a Case and Review of the Literature-

Desmoplastic fibroma of bone is a very rare tumor. Jaffe (1958) described the desmoplastic fibroma of bone as an uncommon benign tumor composed of small fibroblasts in a setting of abundant intercellular material wbich tends to be rich in collagen fibers". Radiologically the lesion tends to present as a centrally located radiolucent lesion in a long bone with a trabeculated or honeycombed appearance. By 1976 fifty cases have been described (Sugi ura , 1976). The rarity of this lesion and recently developed histogenesis of this lesion through electron microscopy prompted us to report the following case

Lipoblastoma (2 cases report)

Authors report two cases of localized type of lipoblastorna occurring in Korean infants, that were successfully treated by total excision. Case 1 was a 10 months old boy who came to the Hospital because of a recurrent inguinal mass that had been removed 5 months previously. The mass was firm and measured Gx 5 x 2cm. Elongated and lobulated masses wcre well encapsulated and delineatcd from the surrounding tissue, and showed light yellowish homogeneous cut surface with areas of rnyxoid change. The tumor mass was separated by irregular complete and incomplete septa. Case ~ was from a 3 months old girl who was found to have a mass in her upper back at the age of one month. This subcutaneous mass measured 2.5 X 2. G>: 2cm, and was elastic firm with mobility. It was well circumscribed from the surrounding tissue, and cut sections showed yellowish lobulated appearance. Microscopically both tumors were characterized by incomplete and complete lobules formed by crisscrossing bands of connective tissue. The tumor masses were composed of undifferentiated mesenchymal cells, fibroblasts, stellate cells as well as univacuolated and multi vacuolated fat cells. Areas of myxoid change were often seen in case 1. Mature fat cells wcre more abundant in the middle of the lobules, whereas the lipoblasts with rich vascularity were secn often around the fibrous septa. Although some neoplastic cells showed some nuclear hyperchrornasia no bizarre or giant cells were noted. Brief comments on age and site incidence, and management of this tumor were made

Total Anomalous Pulmonary Venous Connection -An Autopsy Case Report-

An autopsy case of a total anomalous pulmonary venous connection in a two days old Korean male infant is presented. Four tributaries of the right and left pulmonary veins were found to be joined together to make a common pulmonary vein. The common pulmon ary vein entered directly into righ atrium near the caval orifice. Right atrium was dilated and showed a sickle like septal defect. The right ventricle was hypertrophied, and the muscular portion of the septum contained a round defect. Left heart was rather small In size. In addition to these cardiovascular anomalies, heterotopic pancreas, Meckel s diverticulum and abnormal lobation of the lung were observed