Effect of DHEA on type I and II muscles in a focal cerebral ischemia model rat

학위논문(박사)--서울대학교 대학원 :간호학과 간호학전공,2002.Docto

Hindlimb Muscle Atrophy of Rat Induced by Neuropathic Pain

Purpose: The purpose of this study was to examine the effect of neuropathic pain by peripheral nerve injury on mass and Type I and II fiber cross-sectional areas on hindlimb muscles of the neuropathic pain model rat. Methods: Adult male Sprague-Dawley rats (body weight 200-220 g) were assigned to one of two groups: a neuropathic pain group (n=7) that had a ligation of the left L5 spinal nerve, a control group (n=5), a naive rat without any procedures. Withdrawal threshold, activity, body weight and food intake were measured daily. At 8 days after neuropathic pain, all rats were anesthetized and the soleus and plantaris muscles were dissected from the both hindlimbs. Body weight, food intake, muscle weight and Type I and II fiber cross-sectional area of the dissected muscles were determined. Results: The neuropathic pain group showed a significant decreases (p<.05) as compared with the control rats, in diet intake, body weight, muscle weight and Type II fiber cross-sectional area of the left (affected side) soleus and plantaris muscles, and the right (unaffected side) muscle weight of plantaris and Type II fiber cross-sectional area of the soleus muscle. Conclusion: The hindlimb muscle atrophy occurs in both affected and unaffected side due to neuropathic pain by the peripheral nerve injury. The hindlimb muscle atrophy of the affected side is more pronounced than that of the unaffected side.이 연구는 2007년도 정부(과학기술부)의 재원으로 한국과학재단의 지원을 받아 수행된 연구임(R01-2007-000-10573-0)

Educational Need Assessment of Advanced Practice Nurses on the Pathophysiology

Purpose: Knowledge on pathophysiology is important to understand diseases and patient conditions and also in providing advanced nursing care. This study was performed to investigate the present situation, knowledge, and educational need on pathophyiology of advanced practice nurses (APN). Method: Eighty-four APN, who is practicing in hospitals nationwide, were surveyed with structured questionnaires developed by researchers. The questionnaire were composed of 109 items with 4 point scales with the contents of general characteristics, educational experience on pathophyisology, educational need, and knowledge on major and subcategories of pathophysiology. Result: The 77.1% of APN had experience of taking pathophysiology lecture and the lecturer were mainly medical doctors (39.8%) and APN (32.4%). The 61.5% of APN answered that the knowledge on pathophysiology was helpful and 97.6% of APN thought pathphysiologic education is needed in clinical practice. Seven major categories of pathophysiology showed higher scores were water imbalance, heart diseases, hemodynamic disorders, arterial vessel disorders, electrolyte imbalance, diseases of the digestive system, and diseases of the respiratory systems. Educational needs on the major and subcategories of pathphysiology were different by the field of APN and also by the clinical experiences as APN. APN also responded that there is a necessity to change the present curricular more specific to each practice field and more focus on the clinical practice. Conclusion: It was confirmed that educational and clinical need' on the pathophysiology is very high and there is urgent need to change current curricular more specific to the field of APN and also clinical practice. This survey will help to identify and clarify the areas of change and to improve the education for the APN.본 연구는 2006년도 대한기초간호자연과학회 정책연구비 지원으로 수행되었음

서울대 간호학 박사학위논문 분석을 통한 간호학 연구의 경향

Purpose: The purpose of this study was to identify the trend of nursing research by analyzing doctoral dissertations of nursing college at Seoul National University. Method: The doctoral dissertations used in this study were 69 thesis from 1989 to 2001. The methodological characteristics, theory, philosophy and world view in these thesis were explored. Key words were classified according to metaparadigm and were compared with MeSH term. Result: There were 54 dissertations of quantitative research and 12 dissertations of qualitative research. Most of subjects of the thesis were patients with 20~65 years old. The written consent to participate in research was not described in great part of thesis. As to measurement, questionnaire was most frequent used. In independent variables cognitive nursing interventions were used frequent1y. Psychosocial variables as a dependent variable were used mainly. In theory level of research, situation-producing research was performed. In type of nursing knowledge according to Caper many dissertations studied about empirical knowledge. More than half of doctoral dissertations used borrowed theory from nursing related disciplines. Most of studies were done within empirical positivism and organic viewpoint. Key words related to the concept of environment among four metaparadigm has been insufficient1y studied. English key words in doctoral thesis were out of accordance largely with MeSH term English. Conclusion: These results show that it is necessary to develop the nursing theory for nursing knowledge body