호중구 세포에 대한 팔미트 및 리놀레 산의 효과

학위논문 (석사)-- 서울대학교 대학원 : 치의학과, 2011.2. 최영님.Maste

Large displacement dynamic analysis with frictional contact by linear complementarity formulation

학위논문(박사) - 한국과학기술원 : 기계공학전공, 2002.2, [ ix, 97 p. ]한국과학기술원 : 기계공학전공

Design sensitivity analysis of nonlinear structures in connection with the arc length method

학위논문(석사) - 한국과학기술원 : 기계공학과, 1994.8, [ iv, 51 p. ]한국과학기술원 : 기계공학과

Changes of Pulmonary Function During 60 days of Welding Fume Exposure Period in Sprague-Dawley Rats

Respiratory effects in full time welders include bronchitis, airway irritation, lung function changes, and lung fibrosis. Welder?s pneumoconiosis has been generally determined to be benign and not associated with respiratory symptoms based on the absence of pulmonary function abnormalities in welders with marked radiographic abnormalities. Accordingly, to investigate pulmonary function changes during 60 days induced by welding-fume exposure, male Sprague-Dawley rats were exposed to manual metal arc-stainless steel (MMA-SS) welding fumes with concentrations of 64.8±0.9 mg/m3 (low dose) and 107.8 ±2.6 mg/m3 (high dose) total suspended particulates for 2 hr/day, 5 days/week in an inhalation chamber for 60 days. Pulmonary function was measured every week with whole body plethysmograph compensated (WBP Comp, SFT38116, Buxco Electronics, Sharon, CT). The rats exposed to the high dose of welding fumes exhibited statistically significant (p<0.05-0.01) body weight decrease as compared to the control whereas cell number increase of the bronchoalveolar lavage fluid (BALF) (total cell, macrophage, polymorphonuclear cell and lymphocyte) during the 60 days exposure period. And only tidal volume was significantly decreased in dose-dependantly during 60 days of MMA-SS welding fume exposure. This pulmonary function change with inflammatory cell recruitment confirms the lung injury caused by the MMA-SS welding fume exposure.N