A Study on the Age-Dependent Ketosis Induced by the Ketogenic Diet

Purpose：Ketogenic diet (KD) remains a therapy in search of explanation although it is an established treatment for patients with intractable epilepsy. It has been clinically proven more efficacious at younger ages, presumably because of the enhanced ability of the immature brain to extract and utilize ketone bodies. The study was designed to investigate whether ketosis induced by the KD is agedependent. Methods：A KD ([fat]：[protein+carbohydrate] ratio of 4.3：1) was administered to male Sprague-Dawley rats for 3 weeks, while control animals were fed a standard rodent chow. Dietary treatment was initiated at either postnatal 3 or 12 weeks. Blood β-hydroxybutyrate (BHB) levels were assayed from blood obtained via the tail vein with the Keto-SiteTM reflectance meter and test cards on treatment day 21. Results：Blood BHB levels in the KD-treated group were significantly higher than those in the control group in 3 week-old rats (4.18±0.62 [n=30] vs. 0.27±0.02 [n=30] mM, respectively; p< 0.0001) and 12 week-old rats (0.86±0.06 [n=30] vs. 0.22±0.02 [n=30] mM, respectively; p0.05). Conclusions：The present study demonstrates that the KD induces more severe ketosis in younger rats. Age-dependent differences in the degree of ketosis induced by the KD may explain that the diet is clinically more efficacious at younger ages.OAIID:oai:osos.snu.ac.kr:snu2003-01/102/2014017262/6SEQ:6PERF_CD:SNU2003-01EVAL_ITEM_CD:102USER_ID:2014017262ADJUST_YN:NEMP_ID:A079623DEPT_CD:801CITE_RATE:0DEPT_NM:의학과SCOPUS_YN:NCONFIRM:

Performance analysis of the OSI management protocol for management information scoping

Maste

Process for preparing of blue emitting phosphorparticles by optimizing the precursor materials usingspray pyrolysis

본 발명은 분무열분해법을 이용하는 전구체 최적화에 의한 BAM계 청색 형광체의 제조방법에 관한 것으로서, 더욱 상세하게는 분무열분해법에 의한 플라즈마 디스플레이용 BAM:Eu계 청색 형광체의 제조방법에 있어 모체를 구성하는 바륨, 마그네슘, 알루미늄 전구체 물질간의 조성을 변화시켜 최적의 전구체 조성으로 분무열분해법에 의해 청색 형광체를 제조함으로써, 종래와 같이 콜로이드나 융제를 사용하지 않으면서도 구형을 가지면서 내부가 충진되고 표면 결함이 적어 형광체 분말의 특성 최적화로 우수한 발광 특성을 나타내어 플라즈마 디스플레이에 적합한 다음 화학식 1로 표시되는 BAM계 청색 발광 형광체의 제조방법에 관한 것이다.BaaMgcAldOa+b+c+3/2d:Eub상기 화학식 1에서: 0.5≤ a ≤1.5 이고, 0＜ b ≤0.3 이고, 0.5≤ c ≤2.0 이고, 0＜ d ≤20 이다.분무열분해법, 전구체, BAM계 청색 형광

Morphological change of tungsten heavy alloy by a fourth element

학위논문(박사) - 한국과학기술원 : 재료공학과, 1995.2, [ v, 107 p. ]한국과학기술원 : 재료공학과

PAUF 유전자의 수용체 동정과 특성화에 관한 연구

학위논문(박사) - 한국과학기술원 : 생명과학과, 2009.2, [ vi, 90 p. ]한국과학기술원 : 생명과학과