부조직적합항원 H60 특이적 CD8 T 세포 반응의 특성과 CD8 T 세포 반응 발달에서 골수계 세포의 역할 연구

학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의과학과 의과학전공, 2016. 2. 최은영.The balance between immunity and tolerance is required to maintain immune homeostasis. Understanding how tolerance can be induced extrathymically has important implication for attempts to establish a nonresponsive state to allogeneic antigens borne on tissue grafts and for reestablishing self-tolerance in patients suffering from autoimmune disease. In this study, I investigated whether the induction of help-deficient CD8 T cell response for H60 could generate memory impairment of the H60-specific CD8 T cells and whether the memory impairment of CD8 T cell specific for H60, the most dominant minor H antigen, would influence the immune hierarchy of CD8 T cells specific for other minor H antigens. Helper-deficient CD8 T cells show reduced burst expansion and the tolerance of H60-specific CD8 T cells has rendered CD8 T cells specific for other minor H antigens to be tolerized as well, reducing the total intensity of allo-response induced after transplantation. To understand the thymic selection process for H60-specific CD8 T cells and control of the specific response, I investigated the effect of a single amino acid substitution in the H60 epitope on the composition of the TCR repertoire. These results demonstrated that some overlap in TCR usage between CD8 T cells responding to H60H vs. H60N stimulation, suggesting that the H60H epitope will be useful for understanding the selection process and control of CD8 T cells specific for H60. In the third part, I showed that differentiation of transplanted Lin- cells into myeloid-derived suppressor cells inflamed skin to be the basis of the alleviation of skin inflammation after Lin- cell transplantation. Taken together, these results provide insight for modeling therapeutic applications to control CD8 T cell response.Chapter 1 Effects of CD8 T cell tolerance to dominant minor histocompatibility Ag on the memory response and the immune hierarchy in MHC-matched transplantation 1 Introduction 2 Material and Methods 8 Results 11 Discussion 43 Chapter 2 The effect of single amino acid variation on development of H60-reactive CD8 T cell response 46 Introduction 47 Material and Methods 51 Results 55 Discussion 85 Chapter 3 The role myeloid-derived suppressor cells in the skin inflammation model 89 Introduction 90 Material and Methods 95 Results 102 Discussion 138 References 144 Abstract in Korean 150Docto

MULTICORE APPARATUS AND JOB SCHEDULING METHOD THEREOF

멀티 코어 장치의 각 코어에 할당되는 작업의 최대 건수를 동적으로 관리하여 공유되는 자원에 기인한 코어의 성능 감소를 최소화하는 멀티 코어 장치 및 멀티 코어 장치의 작업 스케줄링 방법이 개시된다. 일 측면에 따른 멀티 코어 장치는 작업 스케줄러에 의해 할당된 작업을 처리하는 코어 및 액티브 사이클 개수 및 스톨 사이클 개수 중의 적어도 하나를 기초로, 코어에 작업을 할당하는 작업 스케줄러를 포함할 수 있다