15 research outputs found
Improvement in fabrication process for reliable and stable stretchable OLED display
No full text학위논문(박사) - 한국과학기술원 : 전기및전자공학부, 2021.2,[v, 71 p. :]최근 웨어러블 전자기기 및 프리폼 (free-form) 형태의 디스플레이가 관심을 받기 시작하면서 유연 디스플레이를 뛰어넘는 스트레처블 디스플레이의 필요성이 대두되고 있다. 이를 위해서 본 학위 논문에서는 기존 선행으로 연구되었던 스트레처블 OLED의 단점들을 보완하고자 구조적으로 신축성있는 디스플레이 개발을 위해 서로 다른 공정방식을 활용하여 기판에 패터닝을 하여 신축성을 부여하고 소자의 특성을 평가해 보았다. 또한 앞서 연구된 기둥구조에 스트레스 저감 효과를 실험적으로 우수성을 분석하였으며 기둥구조의 구조를 변경하여 보다 안정적인 소자의 구동을 확인하여 소자의 안정성을 평가하였다. 또한 포토리소그래피 공정을 통한 기판 설계와 신축성 OLED와 더불어 레이저 커팅을 통하여 신축성 OLED를 제작하여 소자 단위의 스트레처블 OLED를 넘어 스트레처블 디스플레이를 구현해보고자 하였다.한국과학기술원 :전기및전자공학부
(On)The Principle of text evaluation activity for poetry education
No full text학위논문(박사)--서울대학교 대학원 :국어교육과 국어교육전공,2006.Docto
핵 수용체 RORα의 STAT3 신호전달과 간염증 조절 효과 규명
No full text학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과 병태생리학전공, 2016. 2. 이미옥.Chronic liver inflammation plays a critical role in various liver diseases. In an inflammatory region of liver, inflammtory cytokines, IL-6 and IL-22, constitutively activate signal transducer and activator of transcription 3 (STAT3) and exacerbate inflammation induced hepatocellular carcinoma. Therefore, Inhibition of STAT3 activity is important for regulation of liver malignancy. Retonoic acid receptor related orphan receptor α (RORα) is related various metabolism and inflammatory response. Recently, It is reported that RORα attenuates liver metabolic diseases, but it is unknown that RORα has relation with STAT3 activity. To investigate the relationship between RORα and STAT3 in liver inflammation, we used RORα overexpression adenovirus in primary mouse hepatocytes and HepG2 liver cancer cells. Our data showed that RORα overexpression decreased phosphorylation of STAT3 in liver cells. In contrast, RORα knockdown increased phosphorylation of STAT3. Moreover, we observed that RORα overexpression decreased STAT3 transcriptional activity. Synthetic RORα ligands, SR1078 and JC1-40, were also decreased STAT3 transcriptional activity. STAT3 downstream genes, myc and p53, expression was modulated when RORα was overexpressed in HepG2 cells. In order to find how RORα regulates STAT3 activity, we tested endogenous STAT3 regulators expression level when RORα is overexpressed in primary mouse hepatocytes. Four STAT3 regulators that are somatic mutated or downregulated in human cancers, were selected. Our data showed that RORα overexpression downregulated GRIM19 mRNA expression level in primary mouse hepatocytes. Next, we tested effects of RORα ligands in diethylnitrosamine-induced liver inflammation in vivo model. When RORα ligand, JC1-40, was treated, serum ALT and AST levels of mice were decreased and suppression of STAT3 phosphorylation was observed in mouse liver tissue. Infiltrated immune cells number were decreased when JC1-40 was administrated. Also, JC1-40 treatment reduced mRNA expression level of IL-1β and TNFα in liver tissue. In this study, we demonstrated that RORα regulates STAT3 activity by regulation of GRIM19 expression, and RORα ligand reduced STAT3 activity and inflammatory responses in diethylnitrosamine induced liver inflammation in vivo mice model. These findings revealed that RORα is a novel therapeutic target for inflammation-related liver diseases.Ⅰ.INTRODUCTION 1
Ⅱ.PURPOSE OF THE STUDY 7
Ⅲ.MATERIALS AND METHODS 8
1. Cell culture and cell treatment 8
2. Diethylnitrosamine-induced liver inflammation in vivo model 8
3. Recombinant adenovirus infection and siRNA transfection 9
4. Reporter gene assay 9
5. Wetern blot assay 10
6. Quantitative real-time polymerase chain reaction (qRT-PCR) 10
7. Statistic analysis 11
Ⅳ. RESULTS 14
1. RORα inhibits phosphorylation of STAT3 in liver cells 14
2. RORα suppresses the transcriptional activity of STAT3 14
3. RORα increases expression of STAT3 inhibitor, GRIM19 15
4. RORα reduces the diethylnitrosamine-induced inflammatory response and liver injury 16
Ⅴ. DISCUSSION 26
REFERENCES 29
국문초록 34Maste
STRETCHABLE SUBSTRATE
No full text본 발명은 상세하게는 신축성 소재에 탑재되며 도전성을 갖는 스트레처블 기판에 관한 것으로서, 제1 평판형 패턴; 상기 제1 평판형 패턴과 소정 거리 이격된 제2 평판형 패턴; 및 상기 제1 평판형 패턴의 제1 연결점과 상기 제2 평판형 패턴의 제2 연결점을 연결하는 브릿지 패턴; 을 포함하고, 상기 제1 연결점은 상기 제1 평판형 패턴의 면 중 상기 제2 평판형 패턴과 인접한 인접면에 위치하고, 상기 제2 연결점은 상기 제2 평판형 패턴의 면 중 상기 제1 평판형 패턴과 비인접하는 비인접면에 위치할 수 있다
A Study on Improvement of Korean Language National Assessment Educational Achievement in Elementary School
No full textProfessionalism of Korean Language Teachers and the Secondary School Teacher Appointment Examination －With a Focus on the Perceptions of Prospective Korean Language Teachers－
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