Differential expression of Bcl-2, Bax and heat shock proteins in the spinal cord of rat with neuropathic pain

Thesis (doctoral)--서울대학교 대학원 :치의학과,2003.Docto

Zα 단백질에 의해 유도되는 RNA 이중나선과 RNA-DNA 혼합 이중나선의 A form에서 Z form으로의 구조 변화

학위논문 (석사)-- 서울대학교 대학원 : 물리·천문학부(물리학전공), 2011.2. 홍성철.Maste

Sedation for fiberoptic awake nasotracheal intubation : comparison between propofol infusion and intravenous boluses of fentanyl and midazolam

학위논문(석사)--서울대학교 대학원 :치의학과 치과마취학전공,1997.Maste

식물의 중금속 내성에 기여하는 수송체들에 관한 연구

Docto

A Study of the Plasma Level of Cyclic Nucleotides in Bronchial Asthmatics

The plasma levels of cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-mono phosphate (cGMP) and the serum level of aminophylline were measured in bronchial asthmatics. Their ages ranged from 5 years to 89 years and durations of symptom from 3 months to 30 years. Blood samplings were taken between 10:00 AM and 12:00 MD. 1. In bronchia! asthmatics, the mean plasma level of cAMP was 9. 7±7. 1 pmol/ml(mean±S.D., l pmol/ ml to 38pmol/ml) and was significantly higher than that of norma! adults (p<O.01). The mean plasma level of cGMP was 3. 9±1. 7 pmol/ml (mean±S.D., 0.5 pmol/ml to 9.2 pmol/ml) and was not significantly different from normal adults. 2. In bronchial asthmatics without wheezing whose serum levels of aminophylline were not detected, the mean plasma levels of cAMP and cGMP were 8.9± 7.8 pmol/ml and 3. 7±2. 0 pmol/ml respectively. In bronchial asthmatics with wheezing whose serum levels of aminophylline were not detected, the mean plasma levels of cAMP and cGMP were 7. 7±5. 7 pmol/ml and 4.4::1.2.0 prnol/rnl (mean ±S.D.) respectively. There was no significant difference between bronchial asthmatics with wheezing and those without wheezing. 3. In bronchial asthmatics whose serum levels of aminophylline were higher than 2.5pg/ml, the mean plasma level of cAMP was significantly higher than bronchial asthmatics whose serum levels of aminophylline were not detected (p<O.OI). But the mean plasma level of cGMP was not different significa· ntly (p>0.05). 4. There was no correlation between the serum level of aminophylline and the plasma levels of cAMP and cGMP