Biological Markers for Making the Differential Diagnosis between Intraductal Papillary Mucinous Tumor and Mucinous Cystic Tumor of the Pancreas

PURPOSE: Although intraductal papillary mucinous tumor (IPMT) and mucionus cystic tumor (MCT) share many common features, they are 2 clinically different disease entities. The aims of this study were to compare the clinicopathological characteristics of IPMT and MCT and to find molecular markers for making the differential diagnosis between IPMT and MCT METHODS: Forty-one patients with IPMT and 29 MCT patients who all underwent resection between 1994 and 2003 were enrolled in this study. After one gastrointestinal pathologist reviewed the pathological slides, we compared the clinico-pathological features of the two diseases. Immunohistochemical staining with using 17 biological markers was performed to find useful molecular markers for making the differential diagnosis. RESULTS: Besides the clinical features like gender, the tumor size and location, the patient's age and the radiological images, we found differences of the expressions of PR(p<0.001), ER(p<0.001), MUC2(p=0.038) and MUC5A(p=0.001) between IPMT and MCT. CONCLUSION: PR, ER, MUC2 and MUC5A can be useful in making the final differential diagnosis between IPMT and MCT. Considering the different gene expressions, further studies are needed to clarify the different pathogenesis of these two diseases entities.본 연구는 서울대학교병원 일반연구과제(04-2004-027-0)와 보건복지부 암정복추진연구개발사업(No. 0520320)의 지원을 통해 이루어 졌

우리나라 苦衷民願處理體系의 改善方案에 關한 硏究

학위논문(석사)--서울大學校 行政大學院 :行政學科 行政學專攻,1996.Maste

Sirenomelia(An autopsy case report)

Sirenomelia is referred to a monster of fused lower extremities. and is always associated with urogenital system anomalies and often other malformations as well. This paper reports a case of sirenomelia occurring in one of monozygotic twins. The other member of the twin. was normal. The affected male infant died immediately after birth and showed symmelia dipus. This fusion of lower extremities was associated with lumbar meningomyelocele. There were atresia ani as well as agenesis of kidneys, urinary bladder, rectum, urethra and prostate. The brain showed Arnold-Chiari malformation (type II) and internal hydrocephalus. A review of literature on sirenomelia occurring in twins was made, and the pathogenesis of associated cloacal anomalies in sirenomelia was discussed

An Observation on Development of Mammary Glands in Fetuses and Embryos

To evaluate the intra-uterine developmental process of the mammary gland, a microscopic observation was made using 38 normal human fetuses and 10 human embryos. Gestational ages were calculated based on the crown-rump lengths in the fetuses, and organ development (developmental horizons) in the embryos. Following observations were made: 1. The first sign of breast development is recognizable at the 4th gestational week, and was characterized by lens-like thickening of the epidermis and mesenchymal cell condensation. 2. Primordium of mammary gland becomes globoid by the tith gestational week and lobulated by the 7th week, which corresponds to the primary budding. 3. By the 18th week of gestation secondary buds grow downward from the primary buds and they start to branch by the 20th week. 4. The canalization of the lactiferous ducts is started from the 20th week and completed by the 30th gestational week. The secretory materials are first seen in the lumina of the glands by the 28th week of gestation. S. Lymphocytes start to gather around the duct from the 20th week and pronounced throughout the intra-uterine age until term. 6. There is no morphologic difference between male and female in regard to the breast development during the intrauterine life

Mucoepidermoid Carcinoma: a Variant of Cholangiocarcinoma -Report of a Case-

Except for a mixed type of hepatoblastoma in childhood, neoplastic squamous cell component is extremely rare in any malignant epithelial tumor of the liver. Only a few cases of primary squamous cell carcinoma arising from the preexisting cyst of the liver have been reported by Greenwood (1972) and Edmonson (1958). Mucoepidermoid carcinoma, on the other hand, consists of mixture of squamous cell and mucin-producing cell component, occuring predominantly in the salivary glands, lung, and very rarely in the liver (Pianzola & Ricardo, 1971) . We add a case of intrahepatic mucoepi 、de r moid carcinoma to support its histogenesis as a variant of peripheral cholangiocarcinom

Osteogenesis Imperfecta Type II (Two Autopsy Cases)

Osteogenesis imperfecta is one of common hereditary anomalies, but its spectrum appears quite broad. There are many clinical and pathological features which suggest heterogeneity of this disease. We report two cases of osteogenesis imperfecta that we thought best fit for type II. Both cases were born after gestational periods of 30 and 40 weeks, and died immediately after birth. Both clinical and radiological findings were compatible with those of osteogenesis imperfecta in both cases. Major histologic findings were alteration of both endochondral and intramembranous ossification. And interestingly osteoclasts were abundant in the surface 01 lamellar bone and medul1ary spaces as wel1 in both cases. We reviewed the literatures on histologic features and discussed on recently proposed classification of osteogenesis imperfecta

Borderline Lesion(Atypical Epithelial Lesion) of the Stomach

atypical epithelial lesion of the stomach were examined with authors' modified histo-topographic reconst· ruction method, and their pathologic characteristics were discussed along with its histogenesis. Five out of 7 cases were operated for either early or advanced carcinoma of the stomach, and only two were preoperatively diagnosed by endoscopic biopsy and radiological studies. Average age of the cases was 50.6 years, and majority were found in lower portion of stomach and mostly single in number. The lesions were all under 2.0 em in diameter, ranging from O. 5 em to 2. Oem. Macroscopically, they were sessile, poly paid, global and often mulberry-shaped, but 3 were made of flat and/or slightly depressed lesions. Cellular atypism of grade 1 comprised the bulk, with more prominent nuclear stratification and mitotic figures in the basal portion where they accompanied verrucous gastritis. cystic dilatation or intestinal metaplastic changes of proper glands as their underlying disorders below the lesion. And adjacent gastric mucosa represented a diffuse form of severe metaplastic gastritis. Those figures support that the borderline lesion may develop as a sequential step of dedifferentiated metaplastic gastritis during a reparative process of repeated mucosal erosions of the chronic gastritis

Duplication of Urinary Bladder (An autopsy case report)

Duplication of bladder is a rare anomaly and can be a cause of serious clinical condition. This 1-month'0Id male infant presenting with am' phaloce!e and anomaly of external genitalia was found to have double bladder at autopsy. Associated anomalies were dysplasia of the left kidney, incom· plete Y'shaped duplication of left ureter, deviation of penis to the right with hypospadia, cryptorchidism, prolapse of rectal mucosa, and separation of pubes. The cause of death was suspected to be sepsis due to urinary tract infection. Associated anomalies ineluding omphalocele are regarded as secondary to cystic dilatation of duplicated bladde

Arteriovenous Aneurysm of the Great Vein of Galen (An Autopsy Case Report)

An autopsy case of Galen vein aneurysm is reported. This baby was born to a 25 year old primi parous mother after 38 weeks gestation. The pregnancy was uneventful throughout. The mother was working with adhesive of unidentified solvent for 8 hours everyday during her entire gestational period. The baby was edematous and developed marked cyanosis and respiratory difficulty immediately after birth. These symptoms became wOrse and lhe baby expired 3 hours after birth. Postmortem examination showed a marked cardiomegaly , marked venous engorgement of the neck. There was a large aneurysm of 2. 8cm in diameter in the great vein of Galen, and this was fed by pericallosal branch of anterior cerebral artery,central branches of middle cerebral artery, posterior temporal branches of the posterior cerebral artery, and left superior cerebellar artery branch. The entire draining system including straight sinus, transverse sinuses and jugular veins were markedly dilated. The brain showed hydrocephalus with thinning of cerebral mantle. However , no specific malformation other than vascular anomalies was note

A Histopathologic Observation on Squamous Cell Neoplasm of the Forestomach in Rats by Peroral Administration of N-methyl-N'-nitro-N-nitrosoguanidine

A histopathologic study on experimentally induced squamous cell neoplasm of the forestomach in rats by peroral administration of N-methyl-N'-nitro-Nnitrosoguanidine( MNNG) was carried out to clarify the morphologic characteristics and nature of its carcinogenesis. A total of 160 rats were divided into two groups: 130 of experimental group were administered with drinking water containing 83ug/ml MNNG, and 30 control rats with distilled water. After 37 weeks of exposure to MNl'\G, the animals were sacrified and examined. Among the 130 experimetal group, 100 survived more than 32 weeks. Squamous cell papillomas were found in 24 rats(24%). and squamous cell carcinoma in 4 rats (4;'6), one of which was carcinoma in situ. Besides the neoplastic growth, reactive proliferation of the squamous cells such as acanthosis. hyperkeratosis and perakeratosis were frequent associations with or without atypical changes of the basal cells. The possible relationship between these reactive and neoplastic lesions was discussed based on the finding that all experimental animals start with the development of benign reactive and proliferative changes which are subsequently accompanied by cellular atypism as well as papillomatous growth to result in carcinomatous transformation. The proposed histogenesis was compared with that in glandular stomach