7 research outputs found
Synergistic Effect of Fluorination and Molecular Orientational Order Enhances Low-κ of Fluorinated Liquid Crystal Polymer Film
No full textLowering Permittivity in Liquid Crystalline Polymer Film via Addition of Fluorinated Alkyl Chains and Rubbing Process
No full text스크래치 나노그루브를 통한 고배향 세포 정렬 및 상처 치유 드레싱에 응용에 관한 연구
No full text학위논문(석사) - 한국과학기술원 : 화학과, 2023.8,[ii, 36 p. :]Using improper wound care materials may cause impaired wound healing, which can lead to scar formation and infection. In this thesis, we propose a facile method to fabricate a cell-alignment scaffold, which can effectively enhance cell growth and migration, leading to the reproduction of cellular arrangements and restoration of tissues. The fundamental is scratching a substrate with a diamond lapping film that gives uniaxial nanotopography. Cells are seeded to follow the geometric cue via contact guidance, resulting in highly oriented cell alignment. Outstanding biocompatibility is also demonstrated by the high cell viability on various substrates. In vivo studies in a wound healing model in mice demonstrate that the scratched film induces directed cell guidance on the nanostructure, with remarkably reduced wound areas and inhibition of excessive collagen deposition. Rapid recovery of the epidermis and dermis is also witnessed by histological analyses, suggesting the potential application of the scratching technique as an advanced wound dressing material for effective tissue regeneration.한국과학기술원 :화학과
