Eccrine Squamous Syringometaplasia of Underlying Syringoma Associated with Tegafur/Gimeracil/Oteracil (TS-1)

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The pathophysiological role of dendritic cell subsets in psoriasis

Psoriasis is a chronic inflammatory disorder characterized by an erythematous scaly plaque of the skin and is occasionally accompanied by systemic complications. In the psoriatic lesions, an increased number of cytokine-producing dendritic cells and activated T cells are observed, which indicate that psoriasis is a prototype of an immune-mediated dermatosis. During the last decade, emerging studies demonstrate novel roles for the dendritic cell subsets in the process of disease initiation and maintenance of psoriasis. In addition, recently discovered anti-psoriatic therapies, which specifically target inflammatory cytokines produced by lesional dendritic cells, bring much better clinical improvement compared to conventional treatments. These new therapies implicate the crucial importance of dendritic cells in psoriasis pathogenesis. This review will summarize and discuss the dendritic cell subsets of the human skin and their pathophysiological involvement in psoriasis based on mouse- and patient-oriented studies.ope

Inverse Psoriasis Developed in a Patient with Diffuse Large B Cell Lymphoma

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Mean platelet volume is elevated in patients with psoriasis vulgaris

PURPOSE: This retrospective study was done to investigate the mean platelet volume (MPV) level in patients with psoriasis vulgaris and its relationship with disease severity. MATERIALS AND METHODS: We undertook a cross-sectional study on 176 patients and 101 healthy controls to examine the association between MPV and psoriasis. Various clinical and laboratory parameters were analyzed and compared. RESULTS: Platelet distribution width and MPV were significantly higher in patients with psoriasis than controls. In addition, there was positive correlation between Psoriasis Area Severity Index (PASI) and MPV. When psoriasis patients were grouped into mild psoriasis (PASI<10) and moderate to severe psoriasis (PASI≥10), the MPV of the latter group was significantly elevated. Nevertheless, patients with higher MPV level (MPV≥10.4 fL) did not show higher PASI than lower MPV level (MPV<10.4 fL). MPV levels significantly decreased after improvements of psoriasis with various treatments. The variations of MPV and PASI also showed significant correlation. CONCLUSION: We have shown that MPV is increased in psoriasis patients and correlates with disease severity. Therefore, MPV levels may be considered as a marker of disease severity of psoriasis.ope

Analysis of Contact Allergens in Korean Polysensitized Patients by Patch Testing: A Pilot Study

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싸이토카인에 의한 성숙 기간

Dept. of Medicine/석사[한글] 수지상세포는 면역 반응의 유도 및 조절에 중요한 역할을 한다. 미성숙 수지상세포는 MHC class II 경로를 통한 단백질 항원 전달 기능을 매우 효율적으로 수행한다. 성숙 수지상세포는 T 세포의 성장 및 분화를 유발하는 역할을 한다. 인터루킨-12는 수지상세포와 T 세포의 상호 작용에서 매우 중요한 역할을 하는 인자 중 하나이다. 인터루킨-12는 T 세포 및 NK 세포에 작용하여 세포의 성장과 독성을 유발 및 촉진하고, IFN-γ의 생성을 증가시킨다. 인터루킨-12는 Th1 세포를 유발하는데 있어서 가장 중요한 싸이토카인이다. 현재 수지상세포를 이용한 연구는 대부분 CD34 양성 기원세포나 혈액에서 추출한 단핵구를 수지상세포와 유사한 세포로 유도하는 기술을 기반으로 이루어진다.쥐를 이용한 저자들의 실험에서 수지상세포의 표면항원 발현 정도가 아닌 적절한 인터루킨-12의 분비가 수지상세포 면역치료에 있어서 가장 적합한 기준이 된다는 것을 밝혀냈다. 따라서 이번 연구에서 저자들은 인간 단핵구 유래 수지상세포의 표면항원 발현과 세포내 인터루킨-12 발현, 인터루킨-12 분비 등이 일관된 양상을 나타내지 여부를 알아보고자 하였다.연구 결과, 표면항원 발현상으로 수지상세포의 최고 성숙 시기는 7일째이었고, 마찬가지로 세포내 인터루킨-12 표현 정도도 7일째 최고로 높게 나타났다. 본 연구에서 인터루킨-12의 분비량은 그 양이 너무 적어서 의미를 부여하기 힘들기 때문에 자료 분석을 할 수 없었다. 결론적으로 비록 인터루킨-12의 분비량은 적었지만, 표면항원 발현과 세포내 인터루킨-12 발현은 모두 7일째 제일 높게 나타났다. 따라서 수지상세포 면역치료에 있어서 7일째의 수지상세포를 이용하는 것이 적절한 방법 중 하나라고 생각된다. [영문] Dendritic cells (DCs) play an important role in the generation and regulation of immune responses. Immature DCs are very effective in processing native protein antigens for the MHC class II restricted pathway. Mature DCs are specialized to stimulate resting T cells to grow and differentiate. Interleukin-12 (IL-12) is a crucial factor in the moment of dendritic cell/T cell interaction in the lymphoid organ. IL-12 acts on T cells and NK cells by inducing proliferation, enhancing cytotoxicity, and promoting IFN-γ production. It is most important cytokine for induction of Th1 cells. Currently most studies on DCs rely on the in vitro development of DC-like cells from CD34+ progenitor cells of blood monocytes. In our unpublished previous report, proper production of IL-12, not fully expressed molecules representing mature DCs, was optimal criteria of DCs for DCs immunotherapy in murine system. Therefore the purpose of this study is to investigate whether there is discordance among the expressions of surface molecules, intracytoplasmic IL-12 expressions and IL-12 secretion in human monocytes-derived DCs (MoDCs). In this study the optimal day, which DCs become phenotypically most mature, was day 7 and intracytoplasmic IL-12p40 expressions were also highest on day 7. The amounts of IL-12 secreted by mature DCs in this study were so small that they were excluded in data analysis. In conclusion even though the amounts of IL-12 secretions were too small, the pattern of surface molecules expressions and intracytoplasmic IL-12 expressions coincided and both were highest on day 7 in human monocytes-derived DCs. So we think sufficiently matured day 7 DCs are proper candidate to be used in DC immunotherapies.ope

Spontaneous partial regression of naevus of Ota with the development of vitiligo

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Multiple hobnail hemangiomas

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