The effect of cilostazol on hair growth: A type of drug repositioning for the treatment of alopecia with the mechanism of vasodilatation

OAIID:RECH_ACHV_DSTSH_NO:A201703205RECH_ACHV_FG:RR00200003ADJUST_YN:EMP_ID:A079130CITE_RATE:DEPT_NM:의학과EMAIL:[email protected]_YN:CONFIRM:

성인 척추 변형의 수술적 치료의 결과에 대해 악력이 미치는 영향

학위논문(박사) -- 서울대학교대학원 : 의과대학 임상의과학과, 2021.8. 권오상.Purpose: The purpose of this study was to examine the influence of hand grip (HGS) strength on surgical outcomes after surgery for patients with adult spinal deformity (ASD). Study Design: A prospective observational study. Patient Sample: Patients who underwent reconstructive spinal surgery for ASD. Outcome Measures: Oswestry disability index (ODI), EuroQOL (EQ-5D), and visual analog scale (VAS) for back pain. Methods: A total of 78 consecutive patients who underwent reconstructive spinal surgery for ASD were included in this study. Patients were assigned to either the high HGS (≥ 26 kg for men and ≥ 18 kg for women, n = 26) or the low HGS group (< 26 kg for men and < 18 kg for women, n = 52) based on their preoperative HGS. The ODI, EQ-5D, and VAS for back pain were assessed preoperatively, and 3 months, 6 months, and 12 months postoperatively and compared between the two groups. The primary outcome measure was ODI scores 12 months after surgery. The secondary outcome measures included the overall ODI scores, EQ-5D, and VAS for back pain, assessed at each time point during the 1-year follow-up period. Results: As a primary outcome, the ODI score at 12 months after surgery was significantly lower in the high HGS group than the low HGS group (p < 0.009). With regards to the secondary outcome measurements, overall ODI score, EQ-5D and VAS for back pain had better outcomes in the high HGS group across each follow-up assessment (p < 0.001, p < 0.001, and p < 0.001, respectively), while they improved significantly with time after surgery in both groups. Conclusions: Patients with higher preoperative HGS displayed better surgical outcomes, in terms of disability and health-related quality of life at 12 months after reconstructive spinal surgery for ASD. Therefore, the surgical decision for ASD should be made prudently in patients with low HGS.목적: 연구의 목적은 악력이 성인 척추 변형의 교정 수술의 결과에 어떠한 영향을 미치는지 알아보고자 하였다. 연구 설계: 전향적 관찰 연구 환자군: 성인 척추 변형으로 교정 수술을 받기로 예정된 환자 결과 변수: Oswestry disability index (ODI), EuroQOL (EQ-5D), 허리 통증 visual analog scale (VAS) 방법: 성인 척추 변형으로 변형 교정 수술을 시행한 78명의 환자를 대상으로 하였다. 환자들은 악력 측정 결과에 따라 고 악력군 (남자의 경우 ≥ 26kg, 여자의 경우 ≥ 18 kg, n = 26)과 저 악력군 (남자의 경우 < 26 kg, 여자의 경우 < 18 kg, n = 52). ODI, EQ-5D, 허리 통증 VAS 는 수술 전에 측정되었고 수술 후 3, 6, 12개월에 측정되었다. 1차 결과 변수는 수술 후 12개월 시점의 ODI 값으로 하였다. 2차 결과 변수는 모든 시점에서의 ODI, EQ-5D, 허리 통증 VAS로 하였다. 결과: 수술 후 12개월 시점의 ODI 값은 고 악력군에서 저 악력군에 비해 통계적으로 유의하게 낮은 값을 보였다 (p < 0.009). 2차 결과 변수의 분석 결과, ODI score, EQ-5D, 허리 통증 VAS 모두 수술 후 시간이 경과함에 따라 호전되었지만 각각의 변수에서 모두 고 악력군에서 저 악력군에 비해 더 큰 정도의 호전을 보였다 (p < 0.001) 결론: 수술 전 악력이 높은 환자군에서 성인 척추 변형의 교정 수술을 시행하였을 때 수술 후 환자의 주관적인 만족도가 더 우수함을 알 수 있다. 수술의 과 값은 일상생활에서의 장애 정도와 삶의 질을 대변하는 것으로, 악력이 저하된 환자군에서는 수술적 치료의 결정에 유의하여야 함을 본 연구를 통하여 알 수 있다.Introduction 1 Materials and methods 4 Results 10 Discussion 16 Conclusion 20 Bibliography 21 Abstract in Korean 25박

Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study

Background: Graying of hair?a sign of aging?raises cosmetic concerns. Individuals with gray hair often look older than others their age; therefore, some dye their hair for aesthetic purposes. However, hair colorants can induce many problems including skin irritation, allergic reaction and hair-breakage. Objective: This randomized, double-blind clinical trial was performed in order to examine the effects of APHG-1001, a compound including an extract from Pueraria lobata, on graying hair. Methods: A total of 44 female subjects were randomly treated with either APHG-1001 or placebo twice daily for 24 weeks. Using the phototrichogram analysis, a count of newly developed gray hair was estimated. Investigator assessment and subject self-assessment were also performed in order to evaluate the efficacy of the compound. Results: The mean number of newly developed gray hair at 24 weeks was 6.3/cm2 in the APHG-1001 group and 11.4/cm2 in the placebo group; the difference was statistically significant (p＜0.05). However, the investigator assessment and subject self-assessment did not show any significant change in the gross appearance of hair grayness by the end of the study. No severe adverse events in either group were observed. Moreover, the incidence of adverse events did not differ between the groups. Conclusion: This clinical trial revealed that APHG- 1001, which contains an extract of P. lobata, could prevent the development of new gray hair without any remarkable adverse effects. Thus, it can be considered as a viable treatment option for the prevention of gray hair. (Ann Dermatol 25(2) 218∼222, 2013)OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000045457/3SEQ:3PERF_CD:SNU2013-01EVAL_ITEM_CD:102USER_ID:0000045457ADJUST_YN:NEMP_ID:A079130DEPT_CD:801CITE_RATE:.531FILENAME:jo sj, et al ann dermatol 2013.pdfDEPT_NM:의학과EMAIL:[email protected]_YN:YCONFIRM:

Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

The progression of androgenetic alopecia is closely related toandrogen-inducible transforming growth factor (TGF)-β1 secretionby hair follicle dermal papilla cells (DPCs) in bald scalp.Physiological levels of androgen exposure were reported toincrease reactive oxygen species (ROS) generation. In thisstudy, rat vibrissae dermal papilla cells (DP-6) transfected withandrogen receptor showed increased ROS production followingandrogen treatment. We confirmed that TGF-β1 secretion isincreased by androgen treatment in DP-6, whereas androgeninducibleTGF-β1 was significantly suppressed by the ROSscavenger,N-acetyl cysteine. Therefore, we suggest that inductionof TGF-β1 by androgen is mediated by ROS in hair follicleDPCs.This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. A103017) and partially by a research agreement with AmorePacific Corporation, Republic of Korea.OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000045457/8SEQ:8PERF_CD:SNU2013-01EVAL_ITEM_CD:102USER_ID:0000045457ADJUST_YN:NEMP_ID:A079130DEPT_CD:801CITE_RATE:1.634FILENAME:(460-464)bmb 12-228.pdfDEPT_NM:의학과EMAIL:[email protected]_YN:YCONFIRM:

Aging and photoaging dependent changes of epidermal stem cells

학위논문(박사)--서울대학교 대학원 :의학과 피부과학전공,2005.Docto

니코틴이 인공피부 및 인공구강점막의 각화에 미치는 영향

Thesis (master`s)--서울대학교 대학원 :의학과 피부과학 전공,1999.Maste

표면처리를 통한 흑연재료의 산화 저항성 향상

학위논문(석사)--서울대학교 대학원 :재료공학부,2002.Maste

On Studies of Critical Point in Banach Space

Maste

Existence of multi-bump standing waves with a critical frequency for nonlinear Schrodinger equations

DoctorFor a singularly perturbed nonlinear elliptic equation, there are solutions concentrating around critical points or some manifolds with differenctial energy scales with respect to small . In this paper we glue together the solutions