33 research outputs found
The effect of cilostazol on hair growth: A type of drug repositioning for the treatment of alopecia with the mechanism of vasodilatation
OAIID:RECH_ACHV_DSTSH_NO:A201703205RECH_ACHV_FG:RR00200003ADJUST_YN:EMP_ID:A079130CITE_RATE:DEPT_NM:์ํ๊ณผEMAIL:[email protected]_YN:CONFIRM:
์ฑ์ธ ์ฒ์ถ ๋ณํ์ ์์ ์ ์น๋ฃ์ ๊ฒฐ๊ณผ์ ๋ํด ์ ๋ ฅ์ด ๋ฏธ์น๋ ์ํฅ
ํ์๋
ผ๋ฌธ(๋ฐ์ฌ) -- ์์ธ๋ํ๊ต๋ํ์ : ์๊ณผ๋ํ ์์์๊ณผํ๊ณผ, 2021.8. ๊ถ์ค์.Purpose: The purpose of this study was to examine the influence of hand grip (HGS) strength on surgical outcomes after surgery for patients with adult spinal deformity (ASD).
Study Design: A prospective observational study.
Patient Sample: Patients who underwent reconstructive spinal surgery for ASD.
Outcome Measures: Oswestry disability index (ODI), EuroQOL (EQ-5D), and visual analog scale (VAS) for back pain.
Methods: A total of 78 consecutive patients who underwent reconstructive spinal surgery for ASD were included in this study. Patients were assigned to either the high HGS (โฅ 26 kg for men and โฅ 18 kg for women, n = 26) or the low HGS group (< 26 kg for men and < 18 kg for women, n = 52) based on their preoperative HGS. The ODI, EQ-5D, and VAS for back pain were assessed preoperatively, and 3 months, 6 months, and 12 months postoperatively and compared between the two groups. The primary outcome measure was ODI scores 12 months after surgery. The secondary outcome measures included the overall ODI scores, EQ-5D, and VAS for back pain, assessed at each time point during the 1-year follow-up period.
Results: As a primary outcome, the ODI score at 12 months after surgery was significantly lower in the high HGS group than the low HGS group (p < 0.009). With regards to the secondary outcome measurements, overall ODI score, EQ-5D and VAS for back pain had better outcomes in the high HGS group across each follow-up assessment (p < 0.001, p < 0.001, and p < 0.001, respectively), while they improved significantly with time after surgery in both groups.
Conclusions: Patients with higher preoperative HGS displayed better surgical outcomes, in terms of disability and health-related quality of life at 12 months after reconstructive spinal surgery for ASD. Therefore, the surgical decision for ASD should be made prudently in patients with low HGS.๋ชฉ์ : ์ฐ๊ตฌ์ ๋ชฉ์ ์ ์
๋ ฅ์ด ์ฑ์ธ ์ฒ์ถ ๋ณํ์ ๊ต์ ์์ ์ ๊ฒฐ๊ณผ์ ์ด๋ ํ ์ํฅ์ ๋ฏธ์น๋์ง ์์๋ณด๊ณ ์ ํ์๋ค.
์ฐ๊ตฌ ์ค๊ณ: ์ ํฅ์ ๊ด์ฐฐ ์ฐ๊ตฌ
ํ์๊ตฐ: ์ฑ์ธ ์ฒ์ถ ๋ณํ์ผ๋ก ๊ต์ ์์ ์ ๋ฐ๊ธฐ๋ก ์์ ๋ ํ์
๊ฒฐ๊ณผ ๋ณ์: Oswestry disability index (ODI), EuroQOL (EQ-5D), ํ๋ฆฌ ํต์ฆ visual analog scale (VAS)
๋ฐฉ๋ฒ: ์ฑ์ธ ์ฒ์ถ ๋ณํ์ผ๋ก ๋ณํ ๊ต์ ์์ ์ ์ํํ 78๋ช
์ ํ์๋ฅผ ๋์์ผ๋ก ํ์๋ค. ํ์๋ค์ ์
๋ ฅ ์ธก์ ๊ฒฐ๊ณผ์ ๋ฐ๋ผ ๊ณ ์
๋ ฅ๊ตฐ (๋จ์์ ๊ฒฝ์ฐ โฅ 26kg, ์ฌ์์ ๊ฒฝ์ฐ โฅ 18 kg, n = 26)๊ณผ ์ ์
๋ ฅ๊ตฐ (๋จ์์ ๊ฒฝ์ฐ < 26 kg, ์ฌ์์ ๊ฒฝ์ฐ < 18 kg, n = 52). ODI, EQ-5D, ํ๋ฆฌ ํต์ฆ VAS ๋ ์์ ์ ์ ์ธก์ ๋์๊ณ ์์ ํ 3, 6, 12๊ฐ์์ ์ธก์ ๋์๋ค. 1์ฐจ ๊ฒฐ๊ณผ ๋ณ์๋ ์์ ํ 12๊ฐ์ ์์ ์ ODI ๊ฐ์ผ๋ก ํ์๋ค. 2์ฐจ ๊ฒฐ๊ณผ ๋ณ์๋ ๋ชจ๋ ์์ ์์์ ODI, EQ-5D, ํ๋ฆฌ ํต์ฆ VAS๋ก ํ์๋ค.
๊ฒฐ๊ณผ: ์์ ํ 12๊ฐ์ ์์ ์ ODI ๊ฐ์ ๊ณ ์
๋ ฅ๊ตฐ์์ ์ ์
๋ ฅ๊ตฐ์ ๋นํด ํต๊ณ์ ์ผ๋ก ์ ์ํ๊ฒ ๋ฎ์ ๊ฐ์ ๋ณด์๋ค (p < 0.009). 2์ฐจ ๊ฒฐ๊ณผ ๋ณ์์ ๋ถ์ ๊ฒฐ๊ณผ, ODI score, EQ-5D, ํ๋ฆฌ ํต์ฆ VAS ๋ชจ๋ ์์ ํ ์๊ฐ์ด ๊ฒฝ๊ณผํจ์ ๋ฐ๋ผ ํธ์ ๋์์ง๋ง ๊ฐ๊ฐ์ ๋ณ์์์ ๋ชจ๋ ๊ณ ์
๋ ฅ๊ตฐ์์ ์ ์
๋ ฅ๊ตฐ์ ๋นํด ๋ ํฐ ์ ๋์ ํธ์ ์ ๋ณด์๋ค (p < 0.001)
๊ฒฐ๋ก : ์์ ์ ์
๋ ฅ์ด ๋์ ํ์๊ตฐ์์ ์ฑ์ธ ์ฒ์ถ ๋ณํ์ ๊ต์ ์์ ์ ์ํํ์์ ๋ ์์ ํ ํ์์ ์ฃผ๊ด์ ์ธ ๋ง์กฑ๋๊ฐ ๋ ์ฐ์ํจ์ ์ ์ ์๋ค. ์์ ์ ๊ณผ ๊ฐ์ ์ผ์์ํ์์์ ์ฅ์ ์ ๋์ ์ถ์ ์ง์ ๋๋ณํ๋ ๊ฒ์ผ๋ก, ์
๋ ฅ์ด ์ ํ๋ ํ์๊ตฐ์์๋ ์์ ์ ์น๋ฃ์ ๊ฒฐ์ ์ ์ ์ํ์ฌ์ผ ํจ์ ๋ณธ ์ฐ๊ตฌ๋ฅผ ํตํ์ฌ ์ ์ ์๋ค.Introduction 1
Materials and methods 4
Results 10
Discussion 16
Conclusion 20
Bibliography 21
Abstract in Korean 25๋ฐ
Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study
Background: Graying of hair?a sign of aging?raises cosmetic concerns. Individuals with gray hair often look older than others their age; therefore, some dye their hair for aesthetic purposes. However, hair colorants can induce many problems including skin irritation, allergic reaction and hair-breakage. Objective: This randomized, double-blind clinical trial was performed in order to examine the effects of APHG-1001, a compound including an extract from Pueraria lobata, on graying hair. Methods: A total of 44 female subjects were randomly treated with either APHG-1001 or placebo twice daily for 24 weeks. Using the phototrichogram analysis, a count of newly developed gray hair was estimated. Investigator assessment and subject self-assessment were also performed in order to evaluate the efficacy of the compound. Results: The mean number of newly developed gray hair at 24 weeks was 6.3/cm2 in the APHG-1001 group and 11.4/cm2 in the placebo group; the difference was statistically significant (p๏ผ0.05). However, the investigator assessment and subject self-assessment did not show any significant change in the gross appearance of hair grayness by the end of the study. No severe adverse events in either group were observed. Moreover, the incidence of adverse events did not differ between the groups. Conclusion: This clinical trial revealed that APHG- 1001, which contains an extract of P. lobata, could prevent the development of new gray hair without any remarkable adverse effects. Thus, it can be considered as a viable treatment option for the prevention of gray hair. (Ann Dermatol 25(2) 218โผ222, 2013)OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000045457/3SEQ:3PERF_CD:SNU2013-01EVAL_ITEM_CD:102USER_ID:0000045457ADJUST_YN:NEMP_ID:A079130DEPT_CD:801CITE_RATE:.531FILENAME:jo sj, et al ann dermatol 2013.pdfDEPT_NM:์ํ๊ณผEMAIL:[email protected]_YN:YCONFIRM:
Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells
The progression of androgenetic alopecia is closely related toandrogen-inducible transforming growth factor (TGF)-ฮฒ1 secretionby hair follicle dermal papilla cells (DPCs) in bald scalp.Physiological levels of androgen exposure were reported toincrease reactive oxygen species (ROS) generation. In thisstudy, rat vibrissae dermal papilla cells (DP-6) transfected withandrogen receptor showed increased ROS production followingandrogen treatment. We confirmed that TGF-ฮฒ1 secretion isincreased by androgen treatment in DP-6, whereas androgeninducibleTGF-ฮฒ1 was significantly suppressed by the ROSscavenger,N-acetyl cysteine. Therefore, we suggest that inductionof TGF-ฮฒ1 by androgen is mediated by ROS in hair follicleDPCs.This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No. A103017) and partially by a research agreement with AmorePacific Corporation, Republic of Korea.OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000045457/8SEQ:8PERF_CD:SNU2013-01EVAL_ITEM_CD:102USER_ID:0000045457ADJUST_YN:NEMP_ID:A079130DEPT_CD:801CITE_RATE:1.634FILENAME:(460-464)bmb 12-228.pdfDEPT_NM:์ํ๊ณผEMAIL:[email protected]_YN:YCONFIRM:
Aging and photoaging dependent changes of epidermal stem cells
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ผ๋ฌธ(๋ฐ์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :์ํ๊ณผ ํผ๋ถ๊ณผํ์ ๊ณต,2005.Docto
๋์ฝํด์ด ์ธ๊ณตํผ๋ถ ๋ฐ ์ธ๊ณต๊ตฌ๊ฐ์ ๋ง์ ๊ฐํ์ ๋ฏธ์น๋ ์ํฅ
Thesis (master`s)--์์ธ๋ํ๊ต ๋ํ์ :์ํ๊ณผ ํผ๋ถ๊ณผํ ์ ๊ณต,1999.Maste
ํ๋ฉด์ฒ๋ฆฌ๋ฅผ ํตํ ํ์ฐ์ฌ๋ฃ์ ์ฐํ ์ ํญ์ฑ ํฅ์
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ผ๋ฌธ(์์ฌ)--์์ธ๋ํ๊ต ๋ํ์ :์ฌ๋ฃ๊ณตํ๋ถ,2002.Maste
Existence of multi-bump standing waves with a critical frequency for nonlinear Schrodinger equations
DoctorFor a singularly perturbed nonlinear elliptic equation, there are solutions concentrating around critical points or some manifolds with differenctial energy scales with respect to small . In this paper we glue together the solutions