A clinical study on the seizure and spontaneous lobar intracerebral hemorrhage

Background and Objective : Epileptic seizures are frequent complication of lobar hemorrhage. We investigated the factors affecting development of epilepsy following spontaneous lobar ICH. Methods : From January 1986 to July 1999, 114 patients were admitted to Chungnam National University Hospital with spontaneous lobar ICH. We analyzed 75 patients. Excluded were no follow-up(8 patients) and patients died within few days(31 patients). All the patient was followed up at least two years aside from two patients who underwent epileptic seizure and died five and eight months later each. Medical history was obtained through medical record and by telephone interview. Statistical analyses were performed using Chi-square test, Students t - test, Fishers exact test. Results : Seizure occurred in 19 patients. As three patients had previous history of seizures, 16 patients(22.2%) showed first onset early- and late- seizures. Early seizure occurred in 14 patients(19.4%). Three out of 14 were heavy alcoholics. Five patients developed late recurrent seizure 61 days to 800 days after the early seizure. Late seizure with no acute seizure occurred in two patients. The types of seizure were diverse as generalized tonic clonic seizure(10), partial seizure with secondary generalization(5), and complex partial seizure(1). The common risk factors for lobar ICH were hypertension(HT), arteriovenous malformation(AVM), and excessive use of alcohol. We could not find any causes in 23 patients. Although size of hematoma, age of onset, sex, incidence of HT or AVM were not different between patients with seizure and without seizure, the history of excessive alcohol drinking was more frequent in patients with seizure. Five patients with late recurrent seizure had ICH involving temporal area. Conclusions : This study suggests that the risk of seizure in patients with lobar ICH was increase in chronic alcoholics and patient with late recurrent seizure had ICH frequently involving temporal area.OAIID:oai:osos.snu.ac.kr:snu2002-01/102/2014017262/4SEQ:4PERF_CD:SNU2002-01EVAL_ITEM_CD:102USER_ID:2014017262ADJUST_YN:NEMP_ID:A079623DEPT_CD:801CITE_RATE:0DEPT_NM:의학과SCOPUS_YN:NCONFIRM:

(The)Equity premium and volatility bounds

Thesis(masters) --서울대학교 대학원 :경제학부,2008. 8.Maste

전기화학적인 방법을 이용한 DNA 검출에 관한 연구

학위논문(박사) - 한국과학기술원 : 화학과, 2008. 8., [ vi, 49 p. ]We report the new method for detection of DNA hybridization using enzymatic cleavage. The strategy is based on thst S1 nuclease is able to specifically cleave only single strand DNA, but not double strand DNA. The capture probe DNA thiolated single strand DNA labeled with eletroactive ferrocene group, was immobilized on a gold electrode. After hybridization of target DNA of complementary and noncomplementary sequences, nonhybridized single strand DNA was cleaved using S1 nuclease. The difference of enzymatic cleavage on the modified gold electrode was characterized by cyclic voltammetry and differential pulse voltammetry. We successfully applied this method to the sequence-selective discrimination between perfectly matched and mismatched target DNA including a single-base mismatched target DNA. Our method does not require eigher hybridization indicators or other exogenous signaling molecules which most of the electrochemical hybridization detection systems require. The ability to pattern a selective surface with different molecules has importance for molecular electronics and biotechnology applications, as well as for nanoengineering. For this, the patterning of many kinds of biomolecules as probes on the same solid surface is essentially required. Therefore, many research efforts have been focused on the thin film technology including self-assembly method. Most popular method to attach the various biomolecules on surfaces is to form the activating ester by EDC/NHS coulping reaction with carboxylic acid terminated surfaces. However, this method is time-consuming and has drawbacks in selective patterning. We have developed a new electrochemical method to pattern many biomolecules. This is based on electrochemically-induced and site-selective NHS patterning on self-assembled monolayer for subsequent covalent binding of biomolecules. We have studied potential-induced binding of different sequence DNA on microarrayed electrodes and characterized the modified su...한국과학기술원 : 화학과

COMPOSITION FOR INDUCING THE DIFFERENTIATION INTO M2 MACROPHAGE COMPRISING MESOPORUS SILICA NANOPATICLES AND CYTOKINE CONTAINED THEREIN

본 발명의 사이토카인이 담지된 다공성 실리카 나노입자를 포함하는 M2 대식세포로의 분화유도용 조성물은, 사이토카인을 생체 내로 전달하여 단핵구, 대식세포 등이 M2 대식세포로 분화하는 것을 유도함으로써, 과도한 면역 반응을 조절하여 효과적인 면역반응이 일어날 수 있도록 한다

COMPOSITION FOR ANTI-INFLAMMATION COMPRISING MESOPORUS SILICA NANOPARTICLES AND CYTOKINE CONTAINED THEREIN

본 발명의 사이토카인이 담지된 다공성 실리카 나노입자를 포함하는 염증억제용 조성물은 사이토카인을 생체 내로 전달하여 염증 반응이 보다 빠르고 효과적으로 억제될 수 있도록 한다