2014 KISTI 미래유망기술 10선 : 자가면역질환 치료

비매

미국, 유럽연합 및 한국의 천연약물 관련 법규의 비교 연구

학위논문(석사)--서울대학교 대학원 :제약학과 천연물과학전공,2004.Maste

The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-kB and JNK/p38 MAPK activation

*SCI논문임 *Abstract: Fruits of the Litsea family of trees and shrubs contain biologically active compounds, some of which have been used as natural nutrients and flavoring agents in food. In this study,we identified novel anti-nociceptive effects of the 30% ethanol extract, the CH2Cl2 fraction and the associated active components (Hamabiwalactone A and B) from Litsea japonica fruit by using in vivo peripheral and central nervous pain models. In addition, we compared the antiinflammatory effects of several fractions from L. japonica fruit extracts using lipopolysaccharide (LPS)-stimulated Raw264.7 cells. The CH2Cl2 fraction of L. japonica fruit (LJM) had an optimal combination of anti-inflammatory effects and low cytotoxicity. Dose response studies were performed to determine the inhibitory effects of LJM on the pro-inflammatory enzymes, COX-2/PGE2 and NO/iNOS, and pro-inflammatory cytokines, IL-1β, IL-6, and TNF- α. Molecular profiling revealed that LJM exerts anti-inflammatory effects through inhibition of NF-κB and JNK/ p38 MAPK signaling in LPS-induced macrophages. This study suggests that CH2Cl2 fraction of L. japonica fruit and its bioactive components are potential candidates as anti-inflammatory and analgesic agents (painkillers) for the treatment of inflammatory diseases

예방적 레진수복의 미세누출에 관한 연구

학위논문(석사)--서울대학교 대학원 :치의학과 소아치과학전공,2001.Maste

예방적 레진수복의 미세누출에 관한 연구

Preventive resin restoration, extended concept of occlusal pit and fissure sealing, is procedure composed of as follows. Cavity preparation is limited to areas of initial caries The cavity is then restored with composite resin, while other sound pits and fissures are sealed with pit and fissure sealant. If pit and assure sealant with which microrestoration is possible is used, it may be of great benefit to both patient and operator in case of difficult-to-control children s treatment. However study on preventive resin restoration using this kind of materials have been scarce. The purpose of this study was to compare the microleakage of four different modes of preventive resin restoration. Restoration using only composite resin was compared together Fifty-five bicuspids were prepared with small class I cavity preparation on the occlusal surface, divided into the following groups and restored accordingly. Group 1 : Cavity was restored with Z-100 composite resin Group 2 : Cavity was restored with Z-100 composite resin. Pits and fissures were then sealed with Teethmate F-1 Group 3 : Cavity was restored with Z-100 composite resin Pits and fissures were then sealed with Ultraseal XT-plus Group 4 : Cavity and pits and fissures were restored with Ultraseal XT-plus altogrether Group 5 : Cavity was restored with Ultraseal XT-plus. Pits and fissures were then sealed with the same material. After restoration, the samples were thermocycled 500 times between and with a dwell time of 30 seconds. After thermocycling, the samples were dipped into 1% methylene blue solution for 24 hours, then rinsed with tap water. The teeth were then embedded in resin and cut buccolingually along the tooth axis and observed with a stereomicroscope to determine the degree of microleakage. The results were as follows : 1. Group 4 showed the greatest microleakage, while group 3, showed the least. The mean microleakage decreased in the following order:4>1>5>2>3. 2. There was no stastically significant difference between group 1 and group 5(p>0.05). However, group 1 showed significantly greater microleakage compared to group 2 and 3(p0.05). However group 2 showed significantly less microleakage compared to group 4 and 5(p<0.05) 4. Group 3 showed significantly less microleakage compared to group 4 and 5(p<0.05). 5. Group 5 showed significantly less microleakage than group 4(p<0.05)