Colon Type Adenocarcinoma of Appendiceal Orifice with Synchronous Colon Cancer and Appendiceal Mucocele

Primary adenocarcinoma of the appendix is an extraordinarily tare tumor, with fewer than 500 cases described in the collected world literature. However, it has been shown that the incidence of secondary neoplasm, such as synchronous or metachronous lesions, for primary adenocarcinoma of the appendix is much greater than that for colorectal cancer in general. In the present paper, the authors report a case of a 72-year-old male patient with immunoreactivity for P 53 and DCC protein and a review of the literature, who was operated on for an appendiceal orifice cancer and in whom colonic adenomas, a synchronous colon cancer and an appendiceal mucocele, was incidentally discovered after right hemicolectomy. (J Korean Surg Soc 2009;76:398-402) 충수돌기에 발생하는 원발성 악성 종양은 1882년 처음으 로 기술된 이후로, 전 소화기관에 발생하는 암 중에서 5% 미만의 빈도를 보이는 매우 드문 질환이다.(1) 충수의 원발 성 악성 종양을 가진 환자는 동시성과 이시성 악성 종양이 원발성 산발성 대장암보다 9배까지 빈발하여 17∼35%에 이른다고 보고되어왔다.(1,2) 충수 점액낭종은 점액으로 인 해 충수내강이 비정상적으로 확장되어 점막 과형성과 낭선종을 형성하며 악성변화를 일으킬 수 있는 질환으로, 동시 성이나 이시성 악성 종양이 원발성 산발성 대장암보다 6배 까지 빈발하여 11∼23.8%에 이른다고 보고되었다.(3,4) 저자들은 대장의 다발성 선종성 용종으로 내시경적 용종 절제술을 했던 과거력이 있는 72세 남자 환자에서 이후 추 적 대장내시경 관찰 도중 동시성 상행 결장암, 충수 점액낭 종과 함께 충수 기시부 선암이 발견된 증례를 경험하여 문 헌 고찰과 함께 보고한다.CHO JB, 2008, J KOREAN SURG SOC, V74, P429Kataoka M, 2000, ONCOL REP, V7, P99Connor SJ, 1998, DIS COLON RECTUM, V41, P75Shibata D, 1996, NEW ENGL J MED, V335, P1727DEANS GT, 1995, BRIT J SURG, V82, P299YOUNES M, 1995, HISTOPATHOLOGY, V26, P33NITECKI SS, 1994, ANN SURG, V219, P51FERRO M, 1985, DIS COLON RECTUM, V28, P457

Predictive performance of pharmacokinetic models for target concentration-controlled infusion of cefoxitin as a prophylactic antibiotic in patients with colorectal surgery

Aims: We aimed to evaluate the predictive performance of previously constructed cefoxitin pharmacokinetic models and the possibility of administering cefoxitin via the target-controlled infusion (TCI) method in clinical practice. Methods: Cefoxitin (2 g) was dissolved in 50 mL of normal saline to give a concentration of 40 mg mL-1. Before skin incision, cefoxitin was infused with a TCI syringe pump. The target total plasma concentration was set to 80 μg mL-1, which was administered throughout the surgery. Three arterial blood samples were collected to measure the total and free plasma concentrations of cefoxitin at 30, 60, and 120 minutes after the start of cefoxitin administration. The predictive performance of the TCI system was evaluated using four parameters: inaccuracy, divergence, bias, and wobble. Results: The predictive performance of various pharmacokinetic models of cefoxitin was evaluated using 89 total and 89 free plasma concentration measurements from 30 patients. The pooled median (95% confidence interval) biases and inaccuracies were 16.6 (18.4 to 14.8) and 18.5 (16.720.2) for the total concentration model and 20.9 (22.7 to 19.1) and 22.4 (20.624.2) for the free concentration model, respectively. Conclusions: The pooled biases and inaccuracies of the Choi models were clinically acceptable. However, all models consistently produced negatively biased predictions. Administering cefoxitin via the TCI method with a target total concentration of 80 μg mL-1 can maintain a free concentration above 16 μg mL-1 throughout the operation.Maste

Development of high-resolution indirect-microstereolithography technology for fabricating 3-D freeform scaffolds

Docto

대기 장주기 변동 주요 모드의 3차원 구조

학위논문(석사)--서울대학교 대학원 :대기과학과,2000.Maste

Development of Integration Process Based on a Virtual Environment for the Fabrication of Complex Micro-systems Using Micro-stereolithography Technology

Maste

AEROSOL JETTING APPARATUS

본 발명에 따른 에어로졸 분사 장치는 에어로졸이 분사되는 하부 분사구를 가지고 있는 내측 하부 부재, 상기 내측 하부 부재와 제1 간격만큼 이격되어 피복 가스 챔버를 이루며 상기 하부 분사구와 중첩하는 상부 분사구를 가지고 있는 내측 상부 부재, 상기 내측 하부 부재 및 상기 내측 상부 부재와 결합되어 있는 외측 상부 부재를 포함하고, 상기 피복 가스 챔버의 제1 간격은 조절 가능하다. 따라서, 본 발명에 따른 에어로졸 분사 장치는 피복 가스가 분사되는 내측 하부 부재와 내측 상부 부재 사이의 제1 간격을 조절함으로써 박막 패턴의 선폭을 조절할 수 있다

ORGANIC VAPOR-JET PRINTING DEVICE

유기막의 패턴 정밀도를 높일 수 있는 유기 증기젯 인쇄 장치를 제공한다. 유기 증기젯 인쇄 장치는 노즐 블록과, 솔레노이드 밸브, 및 흡입부를 포함한다. 노즐 블록은 내부에 공급 유로와 저장 유로 및 배출 유로를 형성하며, 케리어 가스에 의해 이송된 유기 물질을 공급받아 유기 증기젯을 형성한다. 솔레노이드 밸브는 공급 유로와 저장 유로에 삽입되며 배출 유로보다 큰 직경의 마개부를 구비하는 노즐 본체와, 전기 신호에 따라 노즐 본체를 이동시켜 배출 유로를 개폐시키는 제어부를 포함한다. 흡입부는 노즐 블록에 설치되며, 솔레노이드 밸브의 턴-오프와 동시에 작동하여 배출 유로에 남은 유기 물질을 흡입한다

미세유체시스템과 접촉인쇄기법을 이용한 복합적 나노구조체 형성 및 응용기술 개발

학위논문(박사) - 한국과학기술원 : 기계공학전공, 2013.8, [ xi, 100 p. ]Recently, development of functional devices using various nanostructures including nanowire, nanotube, and nanoparticles has been actively studied. The studies in this field are stimulated as many outstanding properties of electrical, optical, mechanical and chemical in nanoscale have been revealed. Using these properties, functional devices with much better performance can be achieved. Nanostructure synthesis methods can be basically divided into two methods which are top-down and bottom-up. Using the latter method, few nanometers to several tens of nanometer sized nanostructures can be fabricated easily without an additional lithography process, and therefore various functional nanostructures’ bottom-up synthesis methods are widely studied and developed. In this thesis, two kinds of techniques were investigated for the functional device fabrication. First, a microcontact printing technique was used for zinc oxide nanowire (ZnO NW) and functional materials aligned patterning. Second, the microfluidic systems were studied for zinc oxide nanoparticle (ZnO NP) synthesis and silver thin film formation. Each chapters of this thesis described the detailed fabrication process, related physical theories and results. Chapter 2 presents a novel and simple method for the patterned growth of ZnO NWs that combines (1) the direct patterning of ZnO NP seeds via microcontact printing and (2) subsequent low temperature hydrothermal growth. The ZnO NPs can be patterned as seed layers for ZnO NW growth on various substrates including flexible polymer films. The NW geometry and configuration can be controlled by varying the printing conditions (time and pressure) and the hydrothermal reaction time. To assess the possibility of high performance electronic applications of the patterned ZnO NWs, their field emission characteristics will be examined by fabricating a high performance field emission device with a patterned ZnO NW array. Chapter 3 described the developing a novel vacuu...한국과학기술원 : 기계공학전공