The study of N-phosphorylated Amino Acid Esters and the Study on Asymmetric Catalyzed Oxidation of Sulfide

摘要本论文工作包括两部分内容。第一部分：在生命科学中,磷和氨基酸占有重要地位。目前，在生命过程中还未发现不含磷的生命体。N-磷酰化氨基酸及其酯是天然氨基酸的含磷类似物，它们作为最小的酶分子模型，其合成与性能研究引起广泛重视，是近代杂原子化学研究领域的热点之一，且该类化合物还具有抑菌、抗肿瘤、杀虫以及抗植物病毒的活性。磷酰化氨基酸酯上与磷原子相连的两个烷氧基不同以及氨基上取代基的不同将导致生物活性的巨大差异，同时薄荷环也是一种具有多种生物活性的环。综合二者的结构特点和生物活性,本论文采用亚硫酰氯作为氯代试剂，首次合成了一系列含有薄荷环的磷酰化氨基酸酯,并经红外光谱、高分辨质谱、核磁共振谱对其进行...Abstract There are two parts in this thesis. Part I: Phosphoryl compounds and amino acid play crucial roles in life chemistry. N-phosphoryl amino acid and phosphoryl amino acid esters are phosphorous analogs. These kind of compounds also have the activities of anti-bacterial, anticancer, pesticidal and antivirus of plants. It was expected that the different alkyloxy groups in N-phosp...学位：理学硕士院系专业：化学化工学院化学系_有机化学学号：20032503

推荐一个化学生物学教学实验——电喷雾质谱研究磷酰基对丙氨酸与溶菌酶分子间相互作用的影响

介绍一个利用电喷雾质谱研究生物大分子与化学小分子相互作用的实验方法。讨论了该实验在化学生物学专业本科生教学工作中的实践效果

磷酰化氨基酸酯的合成、波谱表征及生物活性

磷酰化氨基酸及其酯属于磷酰胺类,它们作为天然氨基酸的含磷类似物,具有良好的生物活性,它的合成与性质的研究引起人们的浓厚兴趣.本工作用亚硫酰氯先合成磷酰化酰氯,再由其与氨基酸甲酯反应合成了一系列磷酰化氨基酸酯,产物经红外光谱,核磁共振氢谱、碳谱、磷谱,质谱及元素分析鉴定,并初步研究这些化合物的抗菌与抗肿瘤的生物活性

Synthesis, spectral characterization and biological activities of phosphoryl amino acid esters

Phosphoryl amino acids and phosphoryl amino acid esters, as phosphorus analogs of amino acid, have attracted much attention because they show wide biological activities. In this paper, the tide compounds, 2-isopropoxy-(2-isopropyl-5-methyl-cyclohexyloxy)-phosphoryl amino acid esters, were synthesized in the presence of sulfuryl chloride with reasonable yields. Their structures were confirmed by IR, H-1 NMR, C-13 NMR, P-31 NMR and MS spectra, and the antibacterial and antitumor activities of these compounds were given in this paper