经济伦理学的理论基础和时代主题

Abstract in Chinese: 在市场起着决定作用的今天，经济伦理的理论基础可以从人的自由全面发展理论、经济秩序理论、制度变迁理论、社会公正理论等中寻找根据；研究的时代主题包括经济全球化进程中的伦理问题、金融危机引发的经济社会各个领域及各种主题的伦理问题、经济伦理问题研究的政治维度等。Abstract in English: In the present time market has taken a dominant position, economic ethics could found its foundations from comprehensive devel-opment theory, economic order theory, system change theory and social justice theory. And its themes include the ethical problems in the pro-cess of economic globalization, the ethical problems of various themes that have been brought by financial crisis in all fields of this economic society, and the political dimension of the study on economic ethnic problems. [pp.195-196

粘弹性阻尼器对空间桁架结构减震设计与分析

大跨空间结构的振动控制问题一直是人们关注的焦点,其抗震性能的好坏直接关系到人民生命和国家经济财产安全。采用粘弹性阻尼器对大跨空间桁架结构进行减震控制,计算阻尼器相应的力学参数,并对加与未加粘弹性阻尼器结构的地震响应进行对比。分析计算表明:无论在Taft地震波还是在El Centro地震波下,在大跨空间桁架结构中加入粘弹性阻尼器均能有效减小结构的位移、加速度和内力,所加设的粘弹性阻尼器能显著吸收地震输入能量,从而更好地保证结构安全

靶向HIV-1 vif的高效siRNA的筛选及慢病毒介导的体外抗病毒研究

RNAi技术在艾滋病治疗研究中已展现出巨大的潜力,兼具高效抑制特性和保守性的siRNA靶位是其获得成功应用的重要基础。本研究选择以HIV-1 vif基因为靶区筛选高效保守的RNAi序列,共选择设计了30个识别不同位点的siRNA序列,以pSUPER为载体构建了相应的shRNA表达质粒。通过与pNL4-3质粒在293FT细胞中进行共转染抑制实验,以及对初筛获得的高效序列进行保守性分析显示siRNA-vif37序列具有高效抑制效率和较好的保守性特征。通过与pGL3-vif报告质粒的共转染实验证明siRNA-vif37具有vif基因抑制特异性。带有shRNA-vif37表达元件的重组慢病毒转导后的MT-4细胞在HIV-1NL4-3体外攻毒实验中可显示出较有效的抑制病毒复制的能力,本研究进一步对转导后细胞进行克隆化筛选,获得稳定整合shRNA-vif37表达元件的MT-4-vif37细胞克隆,该细胞具有显著的抑制病毒复制的能力,在高攻毒剂量下仍可获得良好的抑制效果。本研究为进一步应用RNAi技术进行新型艾滋病治疗方法研究提供了重要基础

一种可药物筛选及体内检测的新型慢病毒基因治疗载体的构建

为实现基因治疗过程中的有效药物筛选及体内检测,首次利用核糖体内部进入位点(IRES)构建了同时携带O6-烷基鸟嘌呤-DNA烷基转移酶(MGMT)的突变型P140K基因和荧光素酶(Luciferase)基因的慢病毒载体pBobi-MIL。RT-PCR、免疫荧光、药物筛选克隆形成及化学发光检测等实验结果表明感染重组慢病毒L-MIL的细胞能同时表达MGMT及Luciferase。构建成功的新型慢病毒载体为今后的基因治疗奠定了基础,也为慢病毒滴度的确定提供了一种新的可能

Preschool potential development education research of multiple births

【目的】对2002年出生的河北籍缴氏五胞胎兄妹进行教育实验研究,以考察学龄前潜能发展教育对多胞胎幼儿发展的作用。【方法】采用自身对照实验,对五胞胎施以"评估-指导-发展"循环互动模式为基础的个性化潜能发展教育,并对其发展进行阶段性评估,对测验结果进行统计分析。【结果】历经31个月的个性化潜能发展教育,五胞胎的智能发展水平由入园时(4.1岁)的平均智能发育商96.6提高到了6岁时的115,平均提高了19个百分点,干预效果显著。五胞胎6.3岁时的瑞文智商平均达124.6,其中有两人(一男一女)的智商达到130以上。【结论】五胞胎接受个性化潜能发展教育的结果验证了已有的研究发现,即以评估儿童各领域能力发展为基础的个性化教育是一种可行的、有效的早期教育模式。【Objective】 To explore the effect of the potential development preschool education on the development of Xi quintuplets born in Hebei Province,2002.【Methods】 Applying the individualized education in potential development based on ＂evaluation-guidance-development＂ interactive mode,the development of Xi quintuplets was accessed each semester and the test results were analyzed statistically.【Results】 After 31-month potential development individualized education,the average development quotient of the quintuplets rose from 97（4.1 years old）to 115 at age 6,and an average rise of 19 percentages;the intervention effect was significant.The average IQ（CRT）of the quintuplets at age 6.3 years was 124.6;the IQ of two（one boy and one girl among them）,reached over 130.【Conclusions】 The development results of the quintuplets confirm our previous research results that the individualized education,assessing each sub-field of early childhood development,is a feasible and effective form of early education

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies